Oral Contraceptives: Effect on Hemostasis

  • Morris Notelovitz
Part of the Clinical Perspectives in Obstetrics and Gynecology book series (CPOG)


A case report in 1961, that associated the taking of an oral contraceptive for the treatment of endometriosis and pulmonary embolism, led to the linkage between sex steroids and abnormalities in hemostasis.1 A series of epidemiologic studies was subsequently published — primarily from the United Kingdom — which supported this initial clinical observation, and it was concluded that women using oral contraceptives were at increased risk for venous thromboembolic disease.2–4 Subsequently, a relationship was also found between oral contraceptive use and other forms of cardiovascular disease, primarily myocardial infarction and stroke.5–7


Oral Contraceptive Obstet Gynecol Coagulation Cascade Ethinyl Estradiol Plasminogen Activity 
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© Springer-Verlag New York, Inc. 1993

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  • Morris Notelovitz

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