Cytotrophoblast Expression of Integrin Extracellular Matrix Receptors Is Altered in Preeclampsia

  • Yan Zhou
  • Caroline H. Damsky
  • King Chiu
  • James M. Roberts
  • Susan J. Fisher
Conference paper
Part of the Serono Symposia, USA Norwell, Massachusetts book series (SERONOSYMP)


In normal pregnancy human cytotrophoblast invasion of the uterus is the result of an unusual differentiation process in which polarized epithelial cells become detached from the chorionic villus basement membrane, aggregate into multilayered columns of nonpolarized cells, and rapidly penetrate the endometrium, the first third of the myometrium, and the associated spiral arterioles (1–4) (Fig. 7.1). The vascular component of the invasion process gives rise tophysiologic changes, a term used to describe the loss of the endothelial lining and most of the musculoelastic tissue of the spiral arteries, causing a striking increase in the caliber of these vessels (5). These changes occur in preparation for the dramatic increase in blood flow the fetus demands from the mother. The invasion process continues through the first trimester, peaks during the 12th week of pregnancy, and declines rapidly thereafter (1–4). The result is formation of the hemochorial placenta, in which the fetal trophoblast cells are constantly bathed by maternal blood.


Normal Pregnancy Cell Column Invasion Process Integrin Expression Integrin Subunit 
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Copyright information

© Springer-Verlag New York, Inc. 1993

Authors and Affiliations

  • Yan Zhou
  • Caroline H. Damsky
  • King Chiu
  • James M. Roberts
  • Susan J. Fisher

There are no affiliations available

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