Intra-Acrosomal Contraceptive Vaccine Immunogen SP-10 in Human, Macaque, and Baboon

  • John C. Herr
  • Richard M. Wright
  • Charles J. Flickinger
  • Alex Freemerman
  • Kenneth Klotz
  • James Foster
  • John Shannon
Conference paper
Part of the Serono Symposia, USA book series (SERONOSYMP)


SP-10 is an acrosomal protein that is first detected within the developing acrosome of round spermatids in the human testis and persists within the acrosome of mature spermatozoa (1, 2). SP-10 has been designated a primary contraceptive vaccine candidate by a WHO task force on contraceptive vaccines on the basis of several characteristics (3). First, current tissue specificity data suggest that SP-10 is specific to maturing germ cells within the testis (1, 4, 5). Such tissue specificity reduces the likelihood of autoimmune disease arising in females who are administered an SP-10 vaccine. Second, SP-10 has been detected in the sperm of all human males tested to date (N > 200) and thus appears to be conserved among men (2). Third, SP-10 remains associated with the sperm head after the acrosome reaction (2). Finally, a monoclonal antibody to SP-10 (MHS-10) was shown to inhibit human sperm penetration in the hamster egg penetration assay (3). Additional preliminary data have shown human IVF to be inhibited by a monoclonal antibody that reacts with a molecule considered to be SP-10 (6).


Human Sperm Primer Extension Analysis Sperm Extract Prolyl Endopeptidase Female Baboon 
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Copyright information

© Springer-Verlag New York, Inc 1993

Authors and Affiliations

  • John C. Herr
  • Richard M. Wright
  • Charles J. Flickinger
  • Alex Freemerman
  • Kenneth Klotz
  • James Foster
  • John Shannon

There are no affiliations available

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