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Regulation of DNA Synthesis in Leydig Cells

  • Shafiq A. Khan
  • Katja Teerds
  • Jennifer Dorrington
Part of the Serono Symposia, USA book series (SERONOSYMP)

Abstract

In the testis, the gonadotropins LH and FSH are required in vivo for the normal growth and differentiation of the Leydig cells and the Sertoli cells, respectively (1, 2). As a result of the actions of the gonadotropins on the somatic cells of the testis, the appropriate microenvironment is established in the seminiferous tubule that is conducive to the initiation and progression of spermatogenesis (3). LH acts on Leydig cells to stimulate the synthesis and secretion of testosterone, which then acts as a paracrine factor that is essential for spermatogenesis to proceed (4, 5). In intact rats that lack detectable levels of LH, administration of testosterone alone can maintain normal spermatogenesis (6, 7).

Keywords

Sertoli Cell Leydig Cell Seminiferous Tubule Prepubertal Period Deoxyribonucleic Acid Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc. 1994

Authors and Affiliations

  • Shafiq A. Khan
  • Katja Teerds
  • Jennifer Dorrington

There are no affiliations available

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