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Regulation of the Cyclic Nucleotide-Dependent Pathway in Seminiferous Tubule Cells

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Function of Somatic Cells in the Testis

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

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Abstract

It is well established that the development and maturation of the male gamete is dependent on germ cell interaction with somatic cells (1–3). Thus, in the protected environment of the seminiferous tubules, germ cells and somatic cells are continuously exchanging the signals necessary to integrate their functions. In the last 15 years, there has been a major effort to elucidate the biochemical nature of the signals mediating these cell-to-cell interactions (3–5). One concept that has emerged from these studies is that the mechanisms of signal transduction must be operating in seminiferous tubule cells. These mechanisms are necessary for somatic and germ cells to receive and elaborate extracellular signals (6) and to translate them into changes in cell function. Activation of signal transduction pathways must also play an important role in mediating another cell-cell interaction, that between the spermatozoon and the oocyte (7, 8).

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  1. Marco Conti
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  2. Carla Boitani
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  3. Cristina D’Alessandra
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  4. Saveria Iona
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  5. Lucia Monaco
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Editors and Affiliations

  1. Department of Physiology School of Medicine, Southern Illinois University, Carbondale, IL, 62901-6512, USA

    Andrzej Bartke Ph.D.

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Conti, M. et al. (1994). Regulation of the Cyclic Nucleotide-Dependent Pathway in Seminiferous Tubule Cells. In: Bartke, A. (eds) Function of Somatic Cells in the Testis. Serono Symposia, USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2638-3_24

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  • DOI: https://doi.org/10.1007/978-1-4612-2638-3_24

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  • Print ISBN: 978-1-4612-7619-7

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