Intracellular Ca2+ and Insulin Action: Possible Role in the Pathogenesis of Syndrome X

  • Joseph Levy
  • James R. Sowers
Part of the Endocrinology and Metabolism book series (EAM, volume 6)


Overwhelming evidence suggests that binding to the receptor followed by receptor autophosphorylation are the initial steps by which insulin exerts its biologic effects.1-5 However, the subsequent steps in the propagation of the signal are not clear. Indeed, since the biologic effects of insulin are many, it has been suggested that more than one second messenger may be involved in the propagation of the signal.6 Intracellular Ca2+ ([Ca2+]i) may have a significant role in this regard,5 thus explaining why abnormal [Ca2+]i homeostasis may be associated with impaired insulin action7,8 or with insulin resistance.9,10


Insulin Resistance ATPase Activity Essential Hypertension Insulin Action Diabetic Cardiomyopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag New York, Inc. 1994

Authors and Affiliations

  • Joseph Levy
  • James R. Sowers

There are no affiliations available

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