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Calcium Channels, the Pancreatic Islet, and Endocrine Secretion

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Ion Channels and Ion Pumps

Part of the book series: Endocrinology and Metabolism ((EAM,volume 6))

Abstract

Insulin release from the pancreatic islet is stimulated and/or modulated by a variety of metabolic and hormonal factors, paramount among them the concentration of plasma glucose. As is the case for other endocrine and exocrine secretions, Ca2+ appears to be a major mediator of these secretory stimuli. Grodsky and Bennett1 and Milner and Hales2 were the first to show that insulin secretion was markedly impaired in the absence of calcium, an observation later confirmed by other investigators.3,4 Subsequent studies demonstrated that glucose itself increases the concentration of calcium in the cytosol of the ß cell, both by stimulating calcium uptake and by inhibiting calcium efflux through the cell membrane.5–10

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Authors
  1. Joseph C. Dunbar
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Editor information

Editors and Affiliations

  1. 48323, 2104 Rhine Road, West Bloomfield, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Physiology, Wayne State University, 48202, Detroit, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  3. Section of Endocrinology,Department of Internal Medicine,School of Medicine, Wayne State University, 48202, Detroit, MI, USA

    Mary F. Walsh Ph.D. (Assistant Professor) (Assistant Professor)

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© 1994 Springer-Verlag New York, Inc.

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Dunbar, J.C. (1994). Calcium Channels, the Pancreatic Islet, and Endocrine Secretion. In: Foà, P.P., Walsh, M.F. (eds) Ion Channels and Ion Pumps. Endocrinology and Metabolism, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2596-6_4

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  • DOI: https://doi.org/10.1007/978-1-4612-2596-6_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7599-2

  • Online ISBN: 978-1-4612-2596-6

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