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Clinical Pharmacology of Calcium Channels

  • Chapter
Ion Channels and Ion Pumps

Part of the book series: Endocrinology and Metabolism ((EAM,volume 6))

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Abstract

Calcium (Ca2+) influx through plasmalemmal channels, driven by the electrochemical gradient for Ca2+, is a crucial step in several biologic processes such as muscle contraction, neurotransmission, and hormone secretion. As regulators of transmembrane charge movements, Ca2+ channels may also be involved in electric events such as impulse generation and propagation. Ca2+ channels may be regarded as ion-selective pores composed of membrane-spanning glycoproteins, which allow Ca2+ to traverse the lipid bilayer in response to different stimuli.1 The best characterized plasmalemmal Ca2+ channels are those activated by membrane depolarization. These channels are the principal targets of the calcium antagonists presently used in clinical therapy. Ca2+ channels insensitive to changes in membrane potential, such as those activated by agonist-receptor interactions, represent another category of membrane channels.

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Authors
  1. Tore K. Uski
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  2. Edward D. HÖgestÄtt
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  3. Karl-Erik Andersson
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Editors and Affiliations

  1. 48323, 2104 Rhine Road, West Bloomfield, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Physiology, Wayne State University, 48202, Detroit, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  3. Section of Endocrinology,Department of Internal Medicine,School of Medicine, Wayne State University, 48202, Detroit, MI, USA

    Mary F. Walsh Ph.D. (Assistant Professor) (Assistant Professor)

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Uski, T.K., HÖgestÄtt, E.D., Andersson, KE. (1994). Clinical Pharmacology of Calcium Channels. In: Foà, P.P., Walsh, M.F. (eds) Ion Channels and Ion Pumps. Endocrinology and Metabolism, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2596-6_10

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