Design of Chemically Modified and Recombinant Hemoglobins as Potential Red Cell Substitutes

  • James M. Manning


Modified cell-free hemoglobin derivatives have been under study as potential red cell substitutes for nearly three decades (Winslow 1992). These derivatives are prepared by treatment of hemoglobin with some chemical reagent to yield a product that possesses a property considered desirable for a blood substitute. The degree of sophistication of these derivatives has, in general, increased in proportion to our knowledge of hemoglobin itself.


Oxygen Affinity Human Hemoglobin Blood Substitute Chloride Binding Covalent Agent 
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Copyright information

© Birkhäuser Boston 1995

Authors and Affiliations

  • James M. Manning
    • 1
  1. 1.Rockefeller UniversityNew YorkUSA

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