Extracellular Matrix Remodeling at Implantation: Role of Hyaluronan

  • Jeremy J. G. Brown
  • Virginia E. Papaioannou
Conference paper
Part of the Serono Symposia USA book series (SERONOSYMP)


The establishment of pregnancy in species with interstitial, hemochorial placentation (e.g., mouse and human) requires that following displacement of the uterine epithelium, trophoblast cells of the periimplantation blastocyst penetrate the underlying stroma. There, they tap into the maternal vasculature, generating a fetomaternal interface for nutrient and waste exchange. That trophoblast is an intrinsically invasive tissue in these species has been convincingly demonstrated by its behavior in ectopic sites or in the lumen of a nonreceptive uterus from which the epithelium has been stripped (1, 2). In the absence of an appropriate remodeling response by the host tissue, proliferation and invasion proceed in an uncontrolled and unrestricted manner, resulting in choriocarcinoma. In the normal in vivo condition, however, the attachment of a blastocyst to the luminal epithelium of a receptive uterus initiates a cascade of new gene transcription events, resulting in differentiation, or decidualization, of the underlying stroma, such that the maternal tissue becomes resistant to invasion. The trophoblast’s proliferative and invasive potential is consequently limited by the uterine microenvironment, and appropriate differentiative programs are set in motion for the development of a normal, functioning placenta.


Hyaluronic Acid Glandular Epithelium Luminal Epithelium Extracellular Matrix Remodel Mouse Uterus 
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© Springer-Verlag New York, Inc. 1995

Authors and Affiliations

  • Jeremy J. G. Brown
  • Virginia E. Papaioannou

There are no affiliations available

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