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Collagen VI and Laminin as Markers of Differentiation of Endometrial Stroma

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Molecular and Cellular Aspects of Periimplantation Processes

Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

In women, following menstrual shedding, the endometrium regenerates under the influence of estrogen to produce a densely cellular stroma containing narrow tubular glands and small blood vessels (Fig. 22.1). In addition to cellular proliferation, this requires the deposition of a scaffolding of extracellular matrix (ECM) into the often narrow intercellular spaces. The undifferentiated stroma produces an ECM of classically mesenchymal composition: Collagens I, III, V, and VI and fibronectin have all been shown to be present (1–3), and there are periglandular deposits of tenascin (4) that appear to reflect the proliferative state of the epithelial compartment. The epithelium and blood vessels are surrounded by basement membranes containing laminin, collagen type IV, and heparan sulfate proteoglycan (HSPG) (1–3).

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Authors
  1. John D. Aplin
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  2. Panayiota Mylona
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  3. Cay M. Kielty
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  4. Stephen Ball
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Editors and Affiliations

  1. Department of Physiology, University of Kansas Medical Center, Kansas City, KS, 66160, USA

    S. K. Dey Ph.D.

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Aplin, J.D. et al. (1995). Collagen VI and Laminin as Markers of Differentiation of Endometrial Stroma. In: Dey, S.K. (eds) Molecular and Cellular Aspects of Periimplantation Processes. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2548-5_22

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  • DOI: https://doi.org/10.1007/978-1-4612-2548-5_22

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