Nutrient Control of Trophoblast Cell Function?

  • Frank M. Wittmaack
  • Hiroya Matsuo
  • Jerome F. StraussIII
Conference paper
Part of the Serono Symposia USA book series (SERONOSYMP)

Abstract

Much attention has been given recently to the potential roles of hormones, growth factors, cytokines, and the extracellular matrix (ECM) in the regulation of trophoblast function. There is good evidence, mostly from in vitro studies, that all of these factors can influence structural as well as functional features of trophoblast cells. Remarkably, little effort has been devoted to the impact of nutrient cues on trophoblast cell biology. Nutrients are potent regulators of gene expression in prokaryotes. In eukaryotes nutrients also control both transcriptional and posttranscriptional events. This type of regulation is particularly well documented in the gastrointestinal tract and in adipocytes. A high intake of carbohydrate increases the level of glycolytic and lipogenic enzymes, thereby increasing lipogenic capacity in liver and adipose tissue (1). Moreover, dietary glucose is a key determinant of the hepatic transcription rate of several genes, including phosphofructokinase (2), pyruvate kinase (3, 4), acetyl-CoA carboxylase (5), fatty acid synthase (6, 7), and apo E (8).

Keywords

Sucrose Hydrate Carbohydrate Bromide Pyruvate 

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Copyright information

© Springer-Verlag New York, Inc. 1995

Authors and Affiliations

  • Frank M. Wittmaack
  • Hiroya Matsuo
  • Jerome F. StraussIII

There are no affiliations available

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