Abstract
Human placental implantation involves invasion of the uterus by placental trophoblast cells. The extent of this invasion is tightly controlled. Insufficient invasion will lead to inadequate blood supply to the fetoplacental unit, and overextensive invasion will result in placenta percreta (1). The mechanisms that control this trophoblast invasion are not known. The decidua is likely to provide an important element of this control because implantation over areas deficient in decidua, such as over a previous cesarean section scar or in the fallopian tubes, generally shows a significantly greater degree of trophoblast invasion. It is unclear, however, which component of the decidua is important in this regard.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
King A, Loke YW. Unexplained fetal growth retardation: what is the cause? Arch Dis Child 1994; 70: 225–7.
King A, Balendran N, Wooding P, Carter NP, Loke YW. CD3 leukocytes present in the human uterus during early placentation: phenotypic and morphologic characterization of the CD56++ population. Dev Immunol 1991; 1: 169–90.
Burrows T, King A, Loke YW. Expression of adhesion molecules by human decidual large granular lymphocytes. Cell Immunol 1993; 147: 81–94.
Loke YW, Gardner L, Burland K, King A. Laminin in human trophoblastdecidua interaction. Hum Reprod 1989; 4: 457–63.
King A, Wellings V, Gardner L, Loke YW Immunocytochemical characterisation of the unusual large granular lymphocytes in human endometrium throughout the menstrual cycle. Hum Immunol 1989; 24: 195–205.
Loke YW, King A, Drake BL. Leucocytic organisation in the endometrium and fallopian tube. Proc WHO Symp Local Immunity in Reproductive Tract Tissues, New Delhi:187–204.
Kovats S, Main EK, Librach C, Stubblebine M, Fisher SJ, DeMars R. A class I antigen, HLA-G, expressed in human trophoblast. Science 1990; 248: 220–3.
Ellis SA, Palmer MS, McMichael AJ. Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA class I molecule. J Immunol 1990; 144: 731–5.
King A, Birkby C, Loke YW. Early human decidual cells exhibit NK activity against K562 cell line but not against first trimester trophoblast. Cell Immunol 1989; 118: 337–44.
King A, Wooding P, Gardner L, Loke YW. Expression of perform, granzyme A and TIA-1 by human uterine CD56+ cells implies they are activated and capable of effector functions. Hum Reprod 1993; 8: 2061–7.
King A, Loke YW. On the nature and function of human uterine granular lymphocytes. Immunol Today 1991; 12: 432–5.
Ljunggren H-G, Karre K. In search of the ‘missing self’: MHC molecules and NK cell recognition. Immunol Today 1990; 11: 237–44.
Moretta A, Vitale M, Bottino C, et al. P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells: anti-p58 antibodies re-constitute lysis of MHC class I-protected cells in NK clones displaying different specificities. J Exp Med 1993; 178: 597–604.
Raulet DH. A sense of something missing. Nature 1992; 358: 21–2.
Chumbley G, King A, Robertson K, Holmes N, Loke YW. Resistance of HLA-G and HLA-A2 transfectants to lysis by decidual NK cells. Cell Immunol 1994; 155: 312–22.
Loke YW, King A, Chumbley G. Human trophoblast-uterine immunological interactions. In: Soares MJ, Handwerger S, Talamantes F, eds. Trophoblast cells: pathways for maternal-embryonic communication. New York: Springer Verlag, 1993:151–9.
Storkus WJ, Salter RD, Alexander J, et al. Class-1 induced resistance to natural killing: identification of nonpermissive residues in HLA-A2. Proc Natl Acad Sci USA 1991; 88: 5989–92.
King A, Loke YW. Human trophoblast and JEG choriocarcinoma cells are sensitive to lysis by IL-2 stimulated decidual NK cells. Cell Immunol 1990; 129: 435–48.
Jokhi PP, King A, Loke YW. Production of granulocyte-macrophage colony-stimulating factor by human trophoblast cells and by decidual large granular lymphocytes. Hum Reprod 1994; 9: 1660–9.
Jokhi P, King A, Jubinsky P, Loke YW. Demonstration of the low affinity a subunit of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSF-Ra) on human trophoblast and uterine cells. J Reprod Immunol 1994; 26: 147–64.
Loke YW, King A, Gardner L, Carter NP. Evidence for the expression of granulocyte-macrophage colony-stimulating factor receptors by human first trimester extravillous trophoblast and its response to this cytokine. J Reprod Immunol 1992; 22: 33–45.
Loke YW, King A. Recent developments in the human maternal-fetal-immune interaction. Curr Opin Immunol 1991; 3: 762–6.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag New York, Inc.
About this paper
Cite this paper
Loke, Y.W., King, A., Burrows, T., Jokhi, P., Gardner, L. (1995). Role of Decidual Large Granular Lymphocytes/Natural Killer Cells in Human Implantation. In: Dey, S.K. (eds) Molecular and Cellular Aspects of Periimplantation Processes. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2548-5_17
Download citation
DOI: https://doi.org/10.1007/978-1-4612-2548-5_17
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-7575-6
Online ISBN: 978-1-4612-2548-5
eBook Packages: Springer Book Archive