Advertisement

Epidemiology of Atrazine

  • Rolf Loosli
Chapter
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 143)

Abstract

Herbicidal s-triazines have been on the market for more than 35 years; simazine was introduced in 1956 and atrazine in 1957 (Worthing 1991). The current list contains a dozen important compounds (Loosli 1994). Experimental toxicology data suggested s-triazines to be safe in production and in recommended applications to crops. Health data of manufacturers and field workers corroborated the favorable expectations; that is, factories and farms have never reported health effects in personnel.

Keywords

Activate Charcoal Triazine Herbicide Healthy Work Effect Primary Ovarian Tumor Work Environ Health 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Brown LM, Blair A, Gibson R, Everett GD, Cantor KP, Schuman LM, Burmeister, LF, Van Lier SF, Dick F (1990) Pesticide exposures and other agricultural factors for leukemia among men in Iowa and Minnesota. Cancer Res 50:6585–6591.PubMedGoogle Scholar
  2. Cantor KP, Everett GD, Blair A, Gibson R, Schuman LM, Isacson P (1985) Farming and non-Hodgkin’s lymphoma (abstract). Am J Epidemiol 122:535.Google Scholar
  3. Crosignani P, Donna A, Berrino F (1990) Author’s reply. Scand J Work Environ Health 16:446–447.Google Scholar
  4. Delzell E, Sathiakumar N (1992) A combined analysis of mortality among workers at Ciba-Geigy Corporation’s McIntosh and St. Gabriel plants. Unpublished report. University of Alabama, Tuscaloosa.Google Scholar
  5. Deutsche Forschungsgemeinschaft (DFG) (1986) Atrazin. In: Datensammlung zur Toxikologie der Herbizide, 3. Lieferung, VCH Verlagsgesellschaft, Weinheim, Germany.Google Scholar
  6. Donna A, Betta PG, Robutti F, Crosignani P, Berrino F, Bellingeri D (1984) Ovarian mesothelial tumors and herbicides: a case-control study. Carcinogenesis 5: 941–942.PubMedCrossRefGoogle Scholar
  7. Donna A, Crosignani P, Robutti F, Betta PG, Bocca R, Mariani N, Ferrario F, Fissi R, Berrino F (1989) Triazine herbicides and ovarian epithelial neoplasms. Scand J Work Environ Health 15:47–53.PubMedGoogle Scholar
  8. Egyed MN, Nathan A, Eilat A, Shlosberg A (1975) Poisoning in sheep and horses caused by the ingestion of weeds sprayed with simazine and aminotriazole. Refu Vet 32:59–63.Google Scholar
  9. Gallois P, Dereux JF (1979) Manifestations neurologiques symptomatiques d’une interaction chronique aux herbicides (atrazine et tebuthiuron). J Sci Méd Lille 97:261–262.Google Scholar
  10. Gass R (1991) Atrazin-Produktion: Gesundheitsrisiko bei Chemiearbeitern? (poster) Internationale Gesellschaft für Epidemiologie, Europäische Regionaltagung, Basel, Switzerland.Google Scholar
  11. Hapke HJ (1986) Untersuchungen zur Toxikologie des Unkrautvernichters Simazin. Berl Minch Tierärztl Wochenschr 15:301–303.Google Scholar
  12. Hoar SK, Blair A, Holmes FF, Boysen C, Robel RJ (1985) Herbicides and colon cancer (letter to the editor). Lancet i:1277–1278.CrossRefGoogle Scholar
  13. Hoar SK, Blair A, Holmes FF, Boysen C, Robel RJ, Hoover R, Fraumeni JF (1986) Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. J Am Med Assoc 256:1141–1147.CrossRefGoogle Scholar
  14. Hoar Zahm S, Weisenburger DD, Babbitt PA, Saal RC, Cantor KP, Blair A (1988) A case-control study on non-Hodgkin’s lymphoma and agricultural factors in eastern Nebraska (abstract). Am J Epidemiol 128:901.Google Scholar
  15. Hoar Zahm S, Weisenburger DD, Babbitt PA, Saal RC, Vaught JB, Cantor KP, Blair A (1990) A case-control study of non-Hodgkin’s lymphoma and the herbicide 2,4-dichlorphenoxyacetic acid (2,4-n) in eastern Nebraska. Epidemiology 1: 349–356.CrossRefGoogle Scholar
  16. Hoar Zahm S, Weisenburger DD, Cantor KP, Holmes FF, Blair A (1993) Role of the herbicide atrazine in the development of non-Hodgkin’s lymphoma. Scand J Work Environ Health 19:108–114.PubMedGoogle Scholar
  17. International Agency for Research on Cancer (IARC) (1991) Atrazine. In: IARC monographs on the evaluation of carcinogenic risks to humans, vol 53. International Agency for Research on Cancer, Lyon, France, pp 441–466.Google Scholar
  18. Johnson AE, Van Kampen KR, Binns W (1972) Effects on cattle and sheep of eating hay treated with the triazine herbicides atrazine and prometone. Am J Vet Res 33:1433–1438.PubMedGoogle Scholar
  19. Kobel W, Sumner DD, Campbell JB, Hudson DB, Johnson JL (1985) Protective effect of activated charcoal in cattle poisoned with atrazine. Vet Hum Toxicol 27:185–188.PubMedGoogle Scholar
  20. Loosli R (1994) Triazines. In: Tordoir WF, Maroni M, He F (eds) Health surveillance of pesticide workers. Toxicology 91:59–62.Google Scholar
  21. Maroni M, Fait A (1993) Health effects in man from long-term exposure to pesticides. A review of the 1975–1991 literature. Toxicology 78:I-XIII, 1–180.Google Scholar
  22. Milhaud G, Pilaut L (1977) Toxicité des herbicides pour le bétail et le gibier. Rec Méd Vét 153:253–261.Google Scholar
  23. Minder CE (1990) Letter to the editor. Scand J Work Environ Health 16:445–446.PubMedGoogle Scholar
  24. Palmer JS, Radeleff RD (1969) The toxicity of some organic herbicides to cattle, sheep and chickens. Prod Rep 106, U.S. Department of Agriculture, Washington, DC.Google Scholar
  25. Pommery J, Matthieu M, Matthieu D, Lhermitte M (1993) Atrazine in plasma and tissue following atrazine-aminotriazole-ethylene glycol-formaldehyde poisoning. Clin Toxicol 31:323–331.CrossRefGoogle Scholar
  26. Sathiakumar N, Delzell E, Austin H, Cole P (1992) A follow-up study of agricultural chemical production workers. Am J Ind Med 21:321–330.PubMedCrossRefGoogle Scholar
  27. Schmoranzer A, Neumann G, Thiemann KG, Strohbach C (1974) Simazin als leistungsmindernder Faktor bei landwirtschaftlichen Nutztieren und Möglichkeiten der analytischen Erfassung von Triazin-Derivaten. Monatsh Veterinärmed 29: 491–493.Google Scholar
  28. Velvart J (1993) Toxikologie der Haushaltsprodukte. Huber, Bern, 3. Auflage.Google Scholar
  29. Wirth W, Gloxhuber C (1981) Toxikologie. Thieme, Stuttgart, 3. Auflage.Google Scholar
  30. World Health Organization (WHO) (1990) Atrazine health and safety guide. ICPS No 47. World Health Organization, Geneva.Google Scholar
  31. Worthing CR (ed) (1991) The pesticide manual, 9th Ed. British Crop Protection Council, Farnham, Surrey, UK.Google Scholar

Copyright information

© Springer-Verlag New York, Inc. 1995

Authors and Affiliations

  • Rolf Loosli
    • 1
  1. 1.SeltisbergSwitzerland

Personalised recommendations