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Expression of the Wilms’ Tumor Supressor Gene (WT1) in Renal Cell Carcinoma

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Biology of Renal Cell Carcinoma

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Abstract

Wilms’ tumor represents the most common pediatric solid abdominal tumor, with an incidence of 1 in 10,000 live births (1). Histologically, these tumors classically show a triphasic appearance consisting of a mixture of stromal, tubular, and mesenchymal elements in a dysplastic pattem.The tumor is thought to originate from transformed elements of nephrogenic rests which represent embryonic mesenchymal elements in the developing kidney (2, 3). Similar to retinoblastoma, Wilms’ tumors occur in unilaterally and bilaterally, as well as inherited and sporadic forms, with earlier occurrence in bilateral and inherited tumors (1).

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Authors and Affiliations

  1. Department of Cancer Biology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Brian P. Butler M.D., Nishi P. Kuriyan Ph.D., Raymond Rackley M.D., Christine Campbell Ph.D. & Bryan R. G. Williams Ph.D.

  2. Department of Urology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Brian P. Butler M.D. & Raymond Rackley M.D.

Authors
  1. Brian P. Butler M.D.
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  2. Nishi P. Kuriyan Ph.D.
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  3. Raymond Rackley M.D.
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  4. Christine Campbell Ph.D.
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  5. Bryan R. G. Williams Ph.D.
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© 1995 Springer-Verlag New York Inc.

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Butler, B.P., Kuriyan, N.P., Rackley, R., Campbell, C., Williams, B.R.G. (1995). Expression of the Wilms’ Tumor Supressor Gene (WT1) in Renal Cell Carcinoma. In: Biology of Renal Cell Carcinoma. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2536-2_6

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  • DOI: https://doi.org/10.1007/978-1-4612-2536-2_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7571-8

  • Online ISBN: 978-1-4612-2536-2

  • eBook Packages: Springer Book Archive

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