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Molecular Studies of the VHL Tumor Suppressor Gene in Renal Cell Carcinoma

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Biology of Renal Cell Carcinoma

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Abstract

The development and progression of cancer is thought to be due to the accumulation of mutations in growth-regulating genes (1). Inactivation of tumor suppressor genes whose normal function is to control cell growth and activation of oncogenes whose normal function is to stimulate cell growth lead to unrestrained cell proliferation, tumor formation, and metastasis. Renal cell carcinoma is the most common malignancy in the adult kidney and it is estimated that more than 27,000 patients will be diagnosed with this disease and more than 11,000 will die from it in 1994 (2). Both incidence and mortality rates for renal cell carcinoma are increasing.

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Authors and Affiliations

  1. Urologic Oncology Section, Surgery Branch, National Cancer Institute, Bethesda, MD, USA

    James R. Gnarra Ph.D. & W. Marston Linehan M.D.

  2. Laboratory of Immunobiology, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD, USA

    Michael I. Lerman M.D., Ph.D. & Berton Zbar M.D.

Authors
  1. James R. Gnarra Ph.D.
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  2. Michael I. Lerman M.D., Ph.D.
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  3. Berton Zbar M.D.
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  4. W. Marston Linehan M.D.
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© 1995 Springer-Verlag New York Inc.

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Gnarra, J.R., Lerman, M.I., Zbar, B., Linehan, W.M. (1995). Molecular Studies of the VHL Tumor Suppressor Gene in Renal Cell Carcinoma. In: Biology of Renal Cell Carcinoma. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2536-2_4

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  • DOI: https://doi.org/10.1007/978-1-4612-2536-2_4

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7571-8

  • Online ISBN: 978-1-4612-2536-2

  • eBook Packages: Springer Book Archive

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