Role of Growth Hormone in the Promotion of Linear Skeletal Growth

  • Claes Ohlsson
  • Jörgen Isgaard
  • Anders Lindahl
  • Olle G. P. Isaksson
Conference paper
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)


The epiphyseal growth plate is a cartilaginous structure located between the bony epiphysis and the metaphyseal bone. These structures are developmentally regulated and cannot be identified during fetal life. In most species the epiphysis is first seen as a bone nucleus at the time of birth. The growth plate and articular cartilage are then gradually separated by accumulating bone tissue during subsequent growth. Longitudinal bone growth is a result of endochondral ossification in the long bones. During this process a cartilaginous structure is produced by chondrocyte proliferation in the epiphyseal growth plate, and this cartilaginous template is then degenerated and replaced by bone tissue in the direction of the metaphysis (Fig. 9.1).


Growth Hormone Thyroid Hormone Growth Plate Epiphyseal Growth Plate Longitudinal Bone Growth 
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Copyright information

© Springer-Verlag New York, Inc. 1995

Authors and Affiliations

  • Claes Ohlsson
  • Jörgen Isgaard
  • Anders Lindahl
  • Olle G. P. Isaksson

There are no affiliations available

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