Human Growth Hormone Binding Proteins: Regulation and Physiological Significance
Circulating growth hormone binding proteins (GHBPs) have recently been recognized in a variety of species. Their discovery has added a new dimension to the physiology of growth hormone (GH) action. The human high-affinity GHBP, first described in 1986 (1, 2), was subsequently found to represent the soluble ectodomain of the GH receptor (GH-R) (3). This property has attracted considerable attention among basic scientists and clinicians alike. Another circulating GHBP, of lower affinity and probably not related to the GH-R, has received less scrutiny and remains only partially characterized (4). Comprehensive reviews of the GHBPs have recently appeared (5, 6); this chapter summarizes salient features and focuses on aspects that are new and potentially relevant to reproduction. For full citation the reader is referred to the mentioned reviews.
KeywordsGrowth Hormone Follicular Fluid Human Growth Hormone Growth Hormone Receptor Growth Hormone Action
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- 19.Weissberger A J, Ho KKY, Lazarus L. Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor I, and GH-binding protein in postmenopausal women. J Clin Endocrinol Metab 1991; 72: 374–81.PubMedCrossRefGoogle Scholar
- 21.Blumenfeld Z, Barkey RJ, Youdim MBH, Brandes JM, Amit T. Growth hormone (GH) binding protein regulation by estrogen, progesterone, and gonadotropins in human: the effect of ovulation induction with menopausal gonadotropins, GH and gestation. J Clin Endocrinol Metab 1992; 75: 1242–9.PubMedCrossRefGoogle Scholar
- 24.Hochberg Z, Barkey RJ, Even L, Peleg I, Youdim MBH, Amit T. The effect of human growth hormone therapy on GH binding protein in GH-deficient children. Acta Endocrinol (Copenh) 1991; 125: 23–7.Google Scholar
- 31.Mercado M, Baumann G. A growth hormone-binding protein in human milk [Abstract]. Prog 74th meet Endocr Soc, 1992: 225.Google Scholar
- 33.Mannor DA, Shaw MA, Winer LM, Baumann G. Circulating growth liormone-binding protein inhibits growth hormone (GH) binding to GH receptors but not in vivo GH action [Abstract]. Clin Res 1988; 36: 870A.Google Scholar
- 34.Clark RG, Cunningham B, Moore JA,. Growth hormone binding protein enhances the growth promoting activity of GH in the rat [Abstract]. Prog 73rd meet Endocr Soc, 1991: 1611.Google Scholar