Human Growth Hormone Binding Proteins: Regulation and Physiological Significance
Circulating growth hormone binding proteins (GHBPs) have recently been recognized in a variety of species. Their discovery has added a new dimension to the physiology of growth hormone (GH) action. The human high-affinity GHBP, first described in 1986 (1, 2), was subsequently found to represent the soluble ectodomain of the GH receptor (GH-R) (3). This property has attracted considerable attention among basic scientists and clinicians alike. Another circulating GHBP, of lower affinity and probably not related to the GH-R, has received less scrutiny and remains only partially characterized (4). Comprehensive reviews of the GHBPs have recently appeared (5, 6); this chapter summarizes salient features and focuses on aspects that are new and potentially relevant to reproduction. For full citation the reader is referred to the mentioned reviews.
KeywordsObesity Estrogen Cysteine Testosterone Progesterone
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