Human Growth Hormone Binding Proteins: Regulation and Physiological Significance

  • Gerhard Baumann
  • Moises Mercado
  • Norma Davila
  • Melissa Shaw
  • Klaus Amburn
Conference paper
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)


Circulating growth hormone binding proteins (GHBPs) have recently been recognized in a variety of species. Their discovery has added a new dimension to the physiology of growth hormone (GH) action. The human high-affinity GHBP, first described in 1986 (1, 2), was subsequently found to represent the soluble ectodomain of the GH receptor (GH-R) (3). This property has attracted considerable attention among basic scientists and clinicians alike. Another circulating GHBP, of lower affinity and probably not related to the GH-R, has received less scrutiny and remains only partially characterized (4). Comprehensive reviews of the GHBPs have recently appeared (5, 6); this chapter summarizes salient features and focuses on aspects that are new and potentially relevant to reproduction. For full citation the reader is referred to the mentioned reviews.


Growth Hormone Follicular Fluid Human Growth Hormone Growth Hormone Receptor Growth Hormone Action 
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  1. 1.
    Baumann G, Stolar MW, Amburn K, Barsano CP, DeVries BC. A specific growth hormone-binding protein in human plasma: initial characterization. J Clin Endocrinol Metab 1986; 62: 134–41.PubMedCrossRefGoogle Scholar
  2. 2.
    Herington AC, Ymer S, Stevenson J. Identification and characterization of specific binding proteins for growth hormone in normal human sera. J Clin Invest 1986; 7: 1817–23.CrossRefGoogle Scholar
  3. 3.
    Leung DW, Spencer SA, Cachianes G, et al. Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature 1987; 330: 537–43.PubMedCrossRefGoogle Scholar
  4. 4.
    Baumann G, Shaw MA. A second, lower affinity growth hormone-binding protein in human plasma. J Clin Endocrinol Metab 1990; 70: 680–6.PubMedCrossRefGoogle Scholar
  5. 5.
    Baumann G. Minireview: growth hormone-binding proteins. Proc Soc Exp Biol Med 1993; 202: 392–400.PubMedGoogle Scholar
  6. 6.
    Mercado M, Baumann G. Growth hormone-binding proteins. Endocrinologist 1993; 3: 268–77.CrossRefGoogle Scholar
  7. 7.
    Trivedi B, Daughaday WH. Release of growth hormone binding protein from IM-9 lymphocytes by endopeptidase is dependent on sulfhydryl group inac-tivation. Endocrinology 1988; 123: 2201–6.PubMedCrossRefGoogle Scholar
  8. 8.
    Snow KJ, Shaw MA, Winer LM, Baumann G. Diurnal pattern of plasma growth hormone-binding protein in man. J Clin Endocrinol Metab 1990; 70: 417–20.PubMedCrossRefGoogle Scholar
  9. 9.
    Carlsson LMS, Rosberg S, Vitangcol RV, Wong WLT, Albertsson-Wikland K. Analysis of 24-hour plasma profiles of growth hormone (GH)-binding protein, GH/GH-binding protein complex, and GH in healthy children. J Clin Endocrinol Metab 1993; 77: 356–61.PubMedCrossRefGoogle Scholar
  10. 10.
    Baumann G, Vance ML, Shaw MA, Thorner M. Plasma transport of human growth hormone in vivo. J Clin Endocrinol Metab 1990; 71: 470–3.PubMedCrossRefGoogle Scholar
  11. 11.
    Bass SH, Mulkerrin MG, Wells JA. A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor. Proc Natl Acad Sci USA 1991; 88: 4498–502.PubMedCrossRefGoogle Scholar
  12. 12.
    De Vos AM, Ultsch M, Kossiakoff T. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 1992; 255: 306–12.PubMedCrossRefGoogle Scholar
  13. 13.
    Tar A, Hocquette JF, Souberbielle JC, Clot JP, Brauner R, Postel-Vinay M-C. Evaluation of the growth hormone-binding proteins in human plasma using high pressure liquid chromatography. J Clin Endocrinol Metab 1990; 71: 1202–7.PubMedCrossRefGoogle Scholar
  14. 14.
    Baumann G, Shaw MA. Plasma transport of the 20,000 dalton variant of human growth hormone (20K): evidence for a 20K-specific binding site. J Clin Endocrinol Metab 1990; 71: 1339–43.PubMedCrossRefGoogle Scholar
  15. 15.
    Baumann G, Shaw MA, Amburn K. Regulation of plasma growth hormone- binding proteins in health and disease. Metabolism 1989; 38: 683–9.PubMedCrossRefGoogle Scholar
  16. 16.
    Daughaday WH, Trivedi B, Andrews BA. The ontogeny of serum GH binding protein in man: a possible indicator of hepatic GH receptor development. J Clin Endocrinol Metab 1987; 65: 1072–4.PubMedCrossRefGoogle Scholar
  17. 17.
    Silbergeld A, Lazar L, Erster B, Keret R, Tepper R, Laron Z. Serum growth hormone binding protein activity in healthy neonates, children and young adults: correlation with age, height and weight. Clin Endocrinol (Oxf) 1989; 31: 295–303.CrossRefGoogle Scholar
  18. 18.
    Massa G, Bouillon R, Vanderschueren-Lodeweyckx M. Serum levels of growth hormone-binding protein and insulin-like growth factor-I during puberty. Clin Endocrinol (Oxf) 1992; 37: 175–80.CrossRefGoogle Scholar
  19. 19.
    Weissberger A J, Ho KKY, Lazarus L. Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor I, and GH-binding protein in postmenopausal women. J Clin Endocrinol Metab 1991; 72: 374–81.PubMedCrossRefGoogle Scholar
  20. 20.
    Postel-Vinay M-C, Tar A, Hocquette J-F, et al. Human growth hormone (GH)-binding proteins are regulated by GH and testosterone. J Clin Endocrinol Metab 1991; 73: 197–202.PubMedCrossRefGoogle Scholar
  21. 21.
    Blumenfeld Z, Barkey RJ, Youdim MBH, Brandes JM, Amit T. Growth hormone (GH) binding protein regulation by estrogen, progesterone, and gonadotropins in human: the effect of ovulation induction with menopausal gonadotropins, GH and gestation. J Clin Endocrinol Metab 1992; 75: 1242–9.PubMedCrossRefGoogle Scholar
  22. 22.
    Baumann G, Davila N, Shaw MA, Jay R, Liebhaber S, Cooke NE. Binding of human growth hormone-variant (hGH-V; placental GH) to growth hormone binding protein in human plasma. J Clin Endocrinol Metab 1991; 73: 1175–9.PubMedCrossRefGoogle Scholar
  23. 23.
    MacLeod JN, Worsley I, Ray J, Friesen HG, Liebhaber SA, Cooke NE. Human growth hormone-variant is a biologically active somatogen and lactogen. Endocrinology 1991; 128: 1298–302.PubMedCrossRefGoogle Scholar
  24. 24.
    Hochberg Z, Barkey RJ, Even L, Peleg I, Youdim MBH, Amit T. The effect of human growth hormone therapy on GH binding protein in GH-deficient children. Acta Endocrinol (Copenh) 1991; 125: 23–7.Google Scholar
  25. 25.
    Martha PM Jr, Reiter EO, Davila N, Shaw MA, Holcombe JH, Baumann G. Serum growth hormone (GH)-binding protein/receptor: an important determinant of GH responsiveness. J Clin Endocrinol Metab 1992; 75: 1464–9.PubMedCrossRefGoogle Scholar
  26. 26.
    Ho KY, Valiontis E, Waters MJ, Rajkovic IA. Regulation of growth hormone binding protein in man: comparison of gel chromatography and immunoprecipitation methods. J Clin Endocrinol Metab 1993; 76: 302–8.PubMedCrossRefGoogle Scholar
  27. 27.
    Amit T, Ishshalom S, Glaser B, Youdim MBH, Hochberg Z. Growth hormone-binding protein in patients with acromegaly. Horm Res 1992; 37: 205–11.PubMedCrossRefGoogle Scholar
  28. 28.
    Mercado M, Carlsson L, Vitangcol R, Baumann G. Growth hormone-binding protein determination in human plasma: a comparison of immunofunctional and growth hormone-binding assays. J Clin Endocrinol Metab 1993; 76: 1291–4.PubMedCrossRefGoogle Scholar
  29. 29.
    Baumann G, Amburn KD, Buchanan TA. The effect of circulating growth hormone-binding protein on metabolic clearance, distribution and degradation of human growth hormone. J Clin Endocrinol Metab 1987; 64: 657–60.PubMedCrossRefGoogle Scholar
  30. 30.
    Amit T, Dirnfeld M, Barkey RJ, et al. Growth hormone-binding protein (GH-BP) levels in follicular fluid from human preovulatory follicles: correlation with serum GH-BP levels. J Clin Endocrinol Metab 1993; 77: 33–9.PubMedCrossRefGoogle Scholar
  31. 31.
    Mercado M, Baumann G. A growth hormone-binding protein in human milk [Abstract]. Prog 74th meet Endocr Soc, 1992: 225.Google Scholar
  32. 32.
    Mannor DA, Winer LM, Shaw MA, Baumann G. Plasma growth hormone binding proteins: effect on growth hormone binding to receptors and on growth hormone action. J Clin Endocrinol Metab 1991; 73: 30–4.PubMedCrossRefGoogle Scholar
  33. 33.
    Mannor DA, Shaw MA, Winer LM, Baumann G. Circulating growth liormone-binding protein inhibits growth hormone (GH) binding to GH receptors but not in vivo GH action [Abstract]. Clin Res 1988; 36: 870A.Google Scholar
  34. 34.
    Clark RG, Cunningham B, Moore JA,. Growth hormone binding protein enhances the growth promoting activity of GH in the rat [Abstract]. Prog 73rd meet Endocr Soc, 1991: 1611.Google Scholar
  35. 35.
    Rieu M, Le Bouc Y, Villares SM, Postel-Vinay M-C. Familial short stature with very high levels of growth hormone binding protein. J Clin Endocrinol Metab 1993; 76: 857–60.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1995

Authors and Affiliations

  • Gerhard Baumann
  • Moises Mercado
  • Norma Davila
  • Melissa Shaw
  • Klaus Amburn

There are no affiliations available

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