Abstract
Two lines of evidence suggested a role for growth hormone (GH) in the reproductive process. The first was the observation that lowering GH levels in female rats delays puberty and decreases ovarian steroidogenesis in response to stimulation by gonadotropins (1). It was also observed that puberty is delayed and prolonged in children with Laron-type dwarfism (2), which is resistant to the action of GH, whereas puberty and gonadal maturation are induced by the administration of GH to hypopysectomized animals (3).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Advis JPS, White S, Ojeda SR. Activation of growth hormone short loop negative feedback delays puberty in the female. Endocrinology 1981; 108: 1343–52.
Laron Z, Sarel R, Pertzelan A. Puberty in Laron type dwarfism. Eur J Pediatr 1980; 134: 79–83.
Shiekholislam BM, Stempfel RS Jr. Hereditary isolated somatotropin deficiency: effects of human growth hormone administration. Pediatrics 1972; 49: 362–74.
Hammond JM. Peptide regulators in the ovarian follicle. Aust J Biol Sci 1981; 34: 491–504.
Adashi EY, Resnick CE, D’Ercole AJ. Insulin-like growth factors as intra- ovarian regulators of granulosa cell growth and function. Endocr Rev 1985; 6: 400–20.
Shoham Z, Homburg R, Owen EO, Conway GS, Ostergaard H, Jacobs HS. The role of treatment with growth hormone in infertile patients. Baillieres Clin Obstet Gynaecol 1992; 6: 267–81.
Homburg R, Eshel A, Abdalla HI, Jacobs HS. Growth hormone facilitates ovulation induction by gonadotrophins. Clin Endocrinol (Oxf) 1988; 29: 113–7.
Adams J, Franks S, Poison DW, et al. Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotropin releasing hormone. Lancet 1985; 2: 1375–8.
Owen EJ, Davies MC, Kingsland CR, et al. The use of a short regimen of buserelin, a gonadotrophin-releasing hormone agonist, and human menopausal gonadotrophin in assisted conception cycles. Hum Reprod 1989; 4: 749–54.
Homburg R, Eshel A, Abdalla HI, et al. Growth hormone facilitates ovulation induction by gonadotrophins. Clin Endocrinol (Oxf) 1988; 29: 113–7.
Homburg R, West C, Torresani T, et al. Co-treatment with human growth hormone and gonadotrophins for induction of ovulation: a controlled clinical trial. Fertil Steril 1990; 53: 254–60.
Owen EJ, West C, Mason BA, et al. Co-treatment with growth hormone of sub-optimal responders in IVF-ET. Hum Reprod 1991; 6: 524–8.
Volpe A, Coukos G, Barreca A, et al. Ovarian response to combined growth hormone-gonadotropin treatment in patients resistant to induction of super- ovulation. Gynecol Endocrinol 1989; 3: 125–34.
Steinkampf MP, Mendelson CR, Simpson ER. Effects of epidermal growth factor and insulin-like growth factor-I on the levels of mRNA encoding aromatase cytochrome P-450 of human ovarian granulosa cells. Mol Cell Endocrinol 1988; 59: 93–7.
D’Ercole AJ, Stiles AD, Underwood LE. Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc Natl Acad Sci USA 1984; 81: 935–9.
Rabinovici J, Dandekar P, Angle MJ, et al. Insulin-like growth factor I (IGF- I) levels in follicular fluid from human preovulatory follicles: correlation with serum IGF-I levels. Fertil Steril 1990; 54: 428–33.
Owen EJ, Shoham Z, Mason BA, et al. Co treatment with growth hormone, following pituitary suppression, for ovarian stimulation in in-vitro fertilization: a randomized, double-blind, placebo-control trial. Fertil Steril 1991; 56: 1104–10.
Blumenfeld Z, Lunenfeld B. The potentiating effect of growth hormone on follicle stimulation with human menopausal gonadotropins in a panhypo- pituitary patient. Fertil Steril 1989; 52: 328–31.
Homburg R, West C, Torresani T, et al. A comparative study of single-dose growth hormone therapy as an adjunct to gonadotrophin treatment for ovulation induction. Clin Endocrinol (Oxf) 1990b; 32: 781–5.
Stanhope R, Brook CGD, Pringle PJ, et al. Induction of puberty by pulsatile gonadotrophin releasing hormone. Lancet 1987; 2: 552–5.
Darendeliler F, Hindmarsh PC, Preece MA, et al. Growth hormone increases rate of pubertal maturation. Acta Endocrinol (Copenh) 1990; 122 /3: 414–6.
Homburg R, West C, Ostergaard H, Jacobs HS. Combined growth hormone and gonadotropin treatment for ovulation induction in patients with non- responsive ovaries. Gynaecol Endocrinol 1991; 5: 33–6.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag New York, Inc.
About this paper
Cite this paper
Jacobs, H.S. (1995). Evidence for the Utility of Growth Hormone in the Enhancement of Ovulation. In: Adashi, E.Y., Thorner, M.O. (eds) The Somatotrophic Axis and the Reproductive Process in Health and Disease. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2518-8_23
Download citation
DOI: https://doi.org/10.1007/978-1-4612-2518-8_23
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-7567-1
Online ISBN: 978-1-4612-2518-8
eBook Packages: Springer Book Archive