Advertisement

Evidence for the Utility of Growth Hormone in the Enhancement of Ovulation

  • Howard S. Jacobs
Conference paper
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)

Abstract

Two lines of evidence suggested a role for growth hormone (GH) in the reproductive process. The first was the observation that lowering GH levels in female rats delays puberty and decreases ovarian steroidogenesis in response to stimulation by gonadotropins (1). It was also observed that puberty is delayed and prolonged in children with Laron-type dwarfism (2), which is resistant to the action of GH, whereas puberty and gonadal maturation are induced by the administration of GH to hypopysectomized animals (3).

Keywords

Growth Hormone Luteinizing Hormone Granulosa Cell Follicular Fluid Ovarian Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Advis JPS, White S, Ojeda SR. Activation of growth hormone short loop negative feedback delays puberty in the female. Endocrinology 1981; 108: 1343–52.PubMedCrossRefGoogle Scholar
  2. 2.
    Laron Z, Sarel R, Pertzelan A. Puberty in Laron type dwarfism. Eur J Pediatr 1980; 134: 79–83.PubMedCrossRefGoogle Scholar
  3. 3.
    Shiekholislam BM, Stempfel RS Jr. Hereditary isolated somatotropin deficiency: effects of human growth hormone administration. Pediatrics 1972; 49: 362–74.Google Scholar
  4. 4.
    Hammond JM. Peptide regulators in the ovarian follicle. Aust J Biol Sci 1981; 34: 491–504.PubMedGoogle Scholar
  5. 5.
    Adashi EY, Resnick CE, D’Ercole AJ. Insulin-like growth factors as intra- ovarian regulators of granulosa cell growth and function. Endocr Rev 1985; 6: 400–20.PubMedCrossRefGoogle Scholar
  6. 6.
    Shoham Z, Homburg R, Owen EO, Conway GS, Ostergaard H, Jacobs HS. The role of treatment with growth hormone in infertile patients. Baillieres Clin Obstet Gynaecol 1992; 6: 267–81.PubMedCrossRefGoogle Scholar
  7. 7.
    Homburg R, Eshel A, Abdalla HI, Jacobs HS. Growth hormone facilitates ovulation induction by gonadotrophins. Clin Endocrinol (Oxf) 1988; 29: 113–7.CrossRefGoogle Scholar
  8. 8.
    Adams J, Franks S, Poison DW, et al. Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotropin releasing hormone. Lancet 1985; 2: 1375–8.PubMedCrossRefGoogle Scholar
  9. 9.
    Owen EJ, Davies MC, Kingsland CR, et al. The use of a short regimen of buserelin, a gonadotrophin-releasing hormone agonist, and human menopausal gonadotrophin in assisted conception cycles. Hum Reprod 1989; 4: 749–54.PubMedGoogle Scholar
  10. 10.
    Homburg R, Eshel A, Abdalla HI, et al. Growth hormone facilitates ovulation induction by gonadotrophins. Clin Endocrinol (Oxf) 1988; 29: 113–7.CrossRefGoogle Scholar
  11. 11.
    Homburg R, West C, Torresani T, et al. Co-treatment with human growth hormone and gonadotrophins for induction of ovulation: a controlled clinical trial. Fertil Steril 1990; 53: 254–60.PubMedGoogle Scholar
  12. 12.
    Owen EJ, West C, Mason BA, et al. Co-treatment with growth hormone of sub-optimal responders in IVF-ET. Hum Reprod 1991; 6: 524–8.PubMedGoogle Scholar
  13. 13.
    Volpe A, Coukos G, Barreca A, et al. Ovarian response to combined growth hormone-gonadotropin treatment in patients resistant to induction of super- ovulation. Gynecol Endocrinol 1989; 3: 125–34.PubMedCrossRefGoogle Scholar
  14. 14.
    Steinkampf MP, Mendelson CR, Simpson ER. Effects of epidermal growth factor and insulin-like growth factor-I on the levels of mRNA encoding aromatase cytochrome P-450 of human ovarian granulosa cells. Mol Cell Endocrinol 1988; 59: 93–7.PubMedCrossRefGoogle Scholar
  15. 15.
    D’Ercole AJ, Stiles AD, Underwood LE. Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc Natl Acad Sci USA 1984; 81: 935–9.PubMedCrossRefGoogle Scholar
  16. 16.
    Rabinovici J, Dandekar P, Angle MJ, et al. Insulin-like growth factor I (IGF- I) levels in follicular fluid from human preovulatory follicles: correlation with serum IGF-I levels. Fertil Steril 1990; 54: 428–33.PubMedGoogle Scholar
  17. 17.
    Owen EJ, Shoham Z, Mason BA, et al. Co treatment with growth hormone, following pituitary suppression, for ovarian stimulation in in-vitro fertilization: a randomized, double-blind, placebo-control trial. Fertil Steril 1991; 56: 1104–10.PubMedGoogle Scholar
  18. 18.
    Blumenfeld Z, Lunenfeld B. The potentiating effect of growth hormone on follicle stimulation with human menopausal gonadotropins in a panhypo- pituitary patient. Fertil Steril 1989; 52: 328–31.PubMedGoogle Scholar
  19. 19.
    Homburg R, West C, Torresani T, et al. A comparative study of single-dose growth hormone therapy as an adjunct to gonadotrophin treatment for ovulation induction. Clin Endocrinol (Oxf) 1990b; 32: 781–5.CrossRefGoogle Scholar
  20. 20.
    Stanhope R, Brook CGD, Pringle PJ, et al. Induction of puberty by pulsatile gonadotrophin releasing hormone. Lancet 1987; 2: 552–5.PubMedCrossRefGoogle Scholar
  21. 21.
    Darendeliler F, Hindmarsh PC, Preece MA, et al. Growth hormone increases rate of pubertal maturation. Acta Endocrinol (Copenh) 1990; 122 /3: 414–6.Google Scholar
  22. 22.
    Homburg R, West C, Ostergaard H, Jacobs HS. Combined growth hormone and gonadotropin treatment for ovulation induction in patients with non- responsive ovaries. Gynaecol Endocrinol 1991; 5: 33–6.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1995

Authors and Affiliations

  • Howard S. Jacobs

There are no affiliations available

Personalised recommendations