Evidence for the Utility of Growth Hormone in the Enhancement of Ovulation
Two lines of evidence suggested a role for growth hormone (GH) in the reproductive process. The first was the observation that lowering GH levels in female rats delays puberty and decreases ovarian steroidogenesis in response to stimulation by gonadotropins (1). It was also observed that puberty is delayed and prolonged in children with Laron-type dwarfism (2), which is resistant to the action of GH, whereas puberty and gonadal maturation are induced by the administration of GH to hypopysectomized animals (3).
KeywordsGrowth Hormone Luteinizing Hormone Granulosa Cell Follicular Fluid Ovarian Stimulation
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