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Common Neoplasms

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Abstract

Lung cancer remains the most frequently diagnosed malignant neoplasm throughout the world and is the number one cause of cancer death in the American male and female. It is responsible for about 25% of all cancer deaths1 and about 6% of all deaths in the United States.2 Since 1930, more people have died from lung cancer than all other types of cancer combined.3 An estimated 175,000 cases of lung cancer will be diagnosed in the United States in 1993.4

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References

  1. Jett JR, Cortese DA, Fonatana RS. Lung cancer: Current concepts. Ca-A Cancer J Clin 1983;33:74–86.

    CAS  Google Scholar 

  2. Silverberg E, Lubera JA. Cancer statistics. Ca-A Cancer J Clin Bull Cancer Prog 1989;39:3–20.

    CAS  Google Scholar 

  3. Silverberg E, Lubera J. Cancer statistics, 1987. Ca-A Cancer J Clin 1987;37:2–19.

    CAS  Google Scholar 

  4. Rosenow EC III. Symposium on intrathoracic neoplasms: Introduction Mayo Clin Proc 1993;68:168–169.

    Google Scholar 

  5. Robbins SL. The respiratory system. In: Pathologic basis of disease. Philadelphia: Saunders, 1974:833–840.

    Google Scholar 

  6. Galofre M, Payne WS, Woolner LB, Claggett OT, Gage RP. Pathologic classification and surgical treatment of bronchogenic carcinoma. Surg Gynecol Obstet 1964;119:51–61.

    PubMed  CAS  Google Scholar 

  7. Selawry OS, Hansen HH. Lung cancer. In: Holland JF, Frei E, eds. Cancer medicine. Part 2. Philadelphia: Lea and Febiger, 1973:1473–1518.

    Google Scholar 

  8. Garfinkel L, Silverberg E. Lung cancer smoking trends in the United States over the past 25 years. Ca-A Cancer J Clin 1991;41:137–165.

    CAS  Google Scholar 

  9. Devesa SS, Blot WJ, Fraumeni JF, Jr. Declining lung cancer rates among young men and women in the United States: a cohort analysis. J Natl Cancer Inst 1989;81:1568–1571.

    PubMed  CAS  Google Scholar 

  10. Glass A. Declining rates of lung cancer in the United States in young men and women. J Natl Cancer Inst 1991;83:368–369.

    PubMed  CAS  Google Scholar 

  11. Parkin DM, Sternsward J, Muir CS. Estimates of twelve major cancers. Inst WHO 1984;62:163–182.

    CAS  Google Scholar 

  12. Cancer Incidence in Five Continents. NYS Med 1989;92:432–433.

    Google Scholar 

  13. Patterns of cancer incidence in five continents: A picture book. Whelan SL, Parkin DM, Masuyer E, eds. IARC Sci Publ #102, Lyon; IARC, 1990:25.

    Google Scholar 

  14. Napalkov NP. Incidence of malignant tumors in the USSR between 1970 and 1980. Voprosky Onkologii 1982;28:26–27.

    CAS  Google Scholar 

  15. Doll R, Gray R, Hafner B, Peto R. Mortality in relation to smoking: Twenty two years’ observations on female British doctors. Br Med J 1980;280:428–429.

    Google Scholar 

  16. Pollack ES, Horm JW. Trends in cancer incidence and mortality in the United States 1969–1976. J Natl Cancer Inst 1980;64:1091–1103.

    PubMed  CAS  Google Scholar 

  17. Hoick SE, Warren CW, Rochat RW, Smith JC. Lung cancer mortality and smoking habits: Mexican-American women. Am J Public Health 1982;72:38–42.

    Google Scholar 

  18. Lam Wk, So SY, Yu DYC. Clinical features of bronchogenic carcinoma in Hong Kong: Review of 480 patients. Cancer (Philadelphia) 1983;52:369–376.

    CAS  Google Scholar 

  19. Stolley PD. Lung cancer in women: Five years later, situation worse. N Engl J Med 1983;309:428–429.

    PubMed  CAS  Google Scholar 

  20. L’Able KA, Hoey JR. Cigarette smoking, lung cancer and Canadian women. Can Med Assoc J 1984;130: 1539–1540.

    Google Scholar 

  21. Harris J. Lung cancer among women: Tennessee. Morb Mortal Wkly Rep 1984;33:586–588.

    Google Scholar 

  22. Wu AH, Henderson BE, Pike MC, Yu MC. Smoking and other risk factors for lung cancer in women. J Natl Cancer Inst 1985;74:747–751.

    PubMed  CAS  Google Scholar 

  23. Stolley PD. Lung cancer: unwanted equality for women. N Engl J Med 1977;297:886–887.

    PubMed  CAS  Google Scholar 

  24. Lung cancer among women. JAMA 1984;252:2806–2811.

    Google Scholar 

  25. Staryzk PM. Lung-cancer deaths: Equality by 2000? N Engl J Med 1983;309:1289–1290.

    Google Scholar 

  26. Andrews JL, Bloom S, Balogh K, Beamis JF. Lung cancer in women: Lahey clinic experience 1957–1980. Cancer (Philadelphia) 1985;55:2894–2898.

    Google Scholar 

  27. Guinee V, Giocco G, Suarez L, et al. Lung cancer and breast cancer among women: Texas. JAMA 1984;251: 2915–2916.

    Google Scholar 

  28. Chen VW. Lung cancer: Leading cause of cancer death in Louisiana white females. J Natl Cancer Inst 1984;73:1–2.

    Google Scholar 

  29. McDuffie HH, Klaassen DJ, Dosman JA. Female-male differences in patients with primary lung cancer. Cancer (Philadelphia) 1987;59:1825–1830.

    CAS  Google Scholar 

  30. Osann KE. Lung cancer in women: The importance of smoking, family history of cancer, and medical history of respiratory disease. Cancer Res 1991;51:4893–4897.

    PubMed  CAS  Google Scholar 

  31. Anderson AE, Buechner HA, Yoger I, Ziskind MM. Bronchogenic carcinoma in young men. Am J Med 1954;16:404–415.

    PubMed  CAS  Google Scholar 

  32. Neuman HW, Ellis FH, McDonald JR. Bronchogenic carcinoma in persons under forty years of age. N Engl J Med 1956;254:502–507.

    PubMed  CAS  Google Scholar 

  33. Rivkin LM, Salyer JM. Bronchogenic carcinoma in men under 40 years of age. Chest 1958;34:521–524.

    CAS  Google Scholar 

  34. Hanbury WJ. Bronchogenic carcinoma in young persons. Br J Cancer 1958;12:202–206.

    PubMed  CAS  Google Scholar 

  35. Large SE, Morgan WKC. Bronchial carcinoma in young adults. Br J Tuberc 1958;52:185–189.

    CAS  Google Scholar 

  36. Hood RH, Campbell DC, Dooley BN. Bronchogenic carcinoma in young people. Dis Chest 1965;48:469–470.

    PubMed  Google Scholar 

  37. Kennedy A. Lung cancer in young adults. Br J Dis Chest 1972;66:147–154.

    PubMed  CAS  Google Scholar 

  38. Kyniakos M, Webber B. Cancer of the lung in young men. J Thorac Cardiovasc Surg 1974;67:634–648.

    Google Scholar 

  39. Putnam JS. Lung carcinoma in young adults. JAMA 1977;238:35–36.

    PubMed  CAS  Google Scholar 

  40. Ganz PA, Vernon SE, Preston D, Coulson WF. Lung cancer in younger patients. West J Med 1980;133:373–378.

    PubMed  CAS  Google Scholar 

  41. DeCaro L, Benfield JR. Lung cancer in young persons. J Thorac Cardiovasc Surg 1982;83:372–376.

    PubMed  CAS  Google Scholar 

  42. Roviaro GC, Varoli F, Zannini P, Fascianella A, Pezzuoli G. Lung cancer in the young. Chest 1985;87:456–459.

    PubMed  CAS  Google Scholar 

  43. McDuffie HH, Klaassen DJ, Dosman JA. Characteristics of patients with primary lung cancer diagnosed at age 50 years or younger. Chest 1989;96:1298–1301.

    PubMed  CAS  Google Scholar 

  44. Jubelirer SJ, Wilson RA. Lung cancer in patients younger than 40 years of age. Cancer (Philadelphia) 1991;67:1436–1438.

    CAS  Google Scholar 

  45. Bourke W, Milstein D, Giura R, et al. Lung cancer in young adults. Chest 1992;102:1723–1729.

    PubMed  CAS  Google Scholar 

  46. Fontenelle LJ. Primary adenocarcinoma of the lung in a child: Review of the literature. Am Surg 1976;42:296–299.

    PubMed  CAS  Google Scholar 

  47. Hartman GE, Shochat SJ. Primary pulmonary neoplasms of childhood: A review. Ann Thorac Surg 1983;36:108–119.

    PubMed  CAS  Google Scholar 

  48. Cayley Ck, Caez HJ, Mersheimer W. Primary bronchogenic carcinoma of the lung in children. Am J Dis Child 1951;82:49–60.

    CAS  Google Scholar 

  49. Niitu Y, Kubota H, Hasegawa S, et al. Lung cancer (squamous cell carcinoma) in adolescence. Am J Dis Child 1974;127:108–110.

    PubMed  CAS  Google Scholar 

  50. LaSalle RJ, Andrassy RJ, Stanford W. Bronchogenic squamous carcinoma in childhood: A case report. J Pediatr Surg 1977;12:519–521.

    CAS  Google Scholar 

  51. Epstein DM, Aronchick JM. Lung cancer in childhood. Med Pediatr Oncol 1989;17:510–513.

    PubMed  CAS  Google Scholar 

  52. McAldowie AM. Primary cancer of the lungs in a child five and a half months old. Lancet 1876;ii:570–57l.

    Google Scholar 

  53. Fielding JE. Smoking: health effects and control. N Engl J Med 1985;313:491–498,

    PubMed  CAS  Google Scholar 

  54. Fielding JE. Smoking: health effects and control. N Engl J Med 1985;313:555–561.

    PubMed  CAS  Google Scholar 

  55. Kabat GC, Wynder EL. Lung cancer in nonsmokers. Cancer (Philadelphia) 1984;53:1214–1221.

    CAS  Google Scholar 

  56. Ochsner A, DeBakey M. Carcinoma of the lung. Arch Surg 1941;42:209–258.

    Google Scholar 

  57. Wynder EL, Graham EA. Tobacco smoking as a possible etiologic factor in bronchogenic carcinoma. A study of six hundred and eighty four proved cases. JAMA 1950;143:329–336.

    CAS  Google Scholar 

  58. Hammond EC, Horn D. Smoking and death rates: report on forty-four months of follow-up of 187,783 men. JAMA 1958;166:1294–1308.

    Google Scholar 

  59. Rogot E, Murray JL. Smoking and cause of death among American veterans: 16 years of observation. Public Health Rep 1980;3:213–222.

    Google Scholar 

  60. Pollin W, Ravenholt RT. Tobacco addiction and tobacco mortality. JAMA 1984;252:2849–2854.

    PubMed  CAS  Google Scholar 

  61. Guyatt GH, Newhouse MT. Are active and passive smoking harmful? Determining causation. Chest 1985;88:445–451.

    PubMed  CAS  Google Scholar 

  62. Shopland DR, Eyre HJ, Pechacek TF. Smoking-attributable cancer mortality in 1991: Is lung cancer now the leading cause of death among smokers in the United States? J Natl Cancer Inst 1991;83:1142–1148.

    PubMed  CAS  Google Scholar 

  63. Peto R, Doll R. Mortality in relation to smoking: 20 years’ observations on male British doctors. Br Med J 1976;1525–1536.

    Google Scholar 

  64. U.S. Department of Health and Human Services. Reducing the Health Consequences of Smoking: 25 years of Progress. A Report of the Surgeon General. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. OHSH Publication No. (CDC) 89-8411, 1989:

    Google Scholar 

  65. Center for Disease Control, Public Health Service, U.S. Department of Health and Human Services. The Health consequences of involuntary smoking. A report of the Surgeon General. DHHS Publ. No. 87-8398. Washington, DC: U.S. Govt. Print. Office, 1986.

    Google Scholar 

  66. National Academy of Sciences. Environmental tobacco smoke: Measuring exposures and assessing health effects. Washington, DC: National Academy Press, 1986.

    Google Scholar 

  67. U.S. Environmental Protection Agency. Health effects of passive smoking: Assessment of lung cancer in adults and respiratory disorders in children. Washington, DC: U.S. Environmental Protection Agency, 1990.

    Google Scholar 

  68. Janerich DT, Thompson D, Varela LR, et al. Lung cancer and exposure to tobacco smoke in the household. N Engl J Med 1990;323:632–636.

    PubMed  CAS  Google Scholar 

  69. Kozlowski LT. Tar and nicotine delivery of cigarettes. What a difference a puff makes. JAMA 1981;245:158–159.

    PubMed  CAS  Google Scholar 

  70. Benowitz NL, Hall SM, Herning RI, Jacobs P III, Jones RT, Osman AL. Smokers of low-yield cigarettes do not consume less nicotine. N Engl J Med 1983; 309:139–142.

    PubMed  CAS  Google Scholar 

  71. Auerbach O, Hammond EC, Garfinkel L. Changes in bronchial epithelium in relation to cigarette smoking, 1955–1960 vs. 1970–1977. N Engl J Med 1979;300: 381–386.

    PubMed  CAS  Google Scholar 

  72. Lee PN, Garfinkel L. Mortality and type of cigarette smoked. J Epidemiol Community Health 1981;35:16–22.

    PubMed  CAS  Google Scholar 

  73. Zang E A, Wynder EL. Cumulative tar exposure: A new index for estimating lung cancer risk among cigarette smokers. Cancer (Philadelphia) 1992;70:69–76.

    CAS  Google Scholar 

  74. Winters TH, DiFranza JR. Radioactivity in cigarette smoke. N Engl J Med 1982;306:364–365.

    PubMed  CAS  Google Scholar 

  75. Martell EA. Radioactivity in cigarette smoke. N Engl J Med 1982;307:309–310.

    Google Scholar 

  76. Cohen JI. Radioactivity in cigarette smoke. N Engl J Med 1982;307:310.

    Google Scholar 

  77. Cohen BS, Harley NH. Radioactivity in cigarette smoke. N Engl J Med 1982;307:309–310.

    Google Scholar 

  78. Hill CR. Radioactivity in cigarette smoke. N Engl J Med 1982;307:311.

    Google Scholar 

  79. Wagner WL. Radioactivity in cigarette smoke. N Engl J Med 1982;307:311.

    Google Scholar 

  80. Ravenholt RT. Radioactivity in cigarette smoke. N Engl J Med 1982;307:312.

    Google Scholar 

  81. Hoffman D. Wynder EL. Radioactivity in cigarette smoke. N Engl J Med 1982,307:312.

    Google Scholar 

  82. Gottlieb LS, Husen LA. Lung cancer among Navajo uranium miners. Chest 1982;81:449–452.

    PubMed  CAS  Google Scholar 

  83. Samet JM, Kutvirt DM, Waxweiler RJ, Key CR. Uranium mining and lung cancer in Navajo men. N Engl J Med 1984;310:1481–1484.

    PubMed  CAS  Google Scholar 

  84. Radford EP, St. Clair Renard KG. Lung cancer in Swedish iron miners exposed to low doses of radon daughters. N Engl J Med 1984;310:1485–1494.

    PubMed  CAS  Google Scholar 

  85. Radford EP. Radon daughters in the induction of lung cancer in underground miners. In: Peto R, Schneiderman M, eds. Quantification of occupational cancer. Cold Spring Harbor, New York: Cold Spring Laboratory, 1981:151–163.

    Google Scholar 

  86. Thomas DC, McNeill KG. Risk estimates for the health effects of alpha radiation. Ottawa: Report to the Canadian Atomic Energy Control Board, 1982.

    Google Scholar 

  87. The Seattle Times, Sunday, Sept 8, 1985.

    Google Scholar 

  88. Indoor air pollution. If you think your home is a bastion of clean air in a polluted world, think again. Consumer Reports 1985;50:600–603.

    Google Scholar 

  89. Committee on the Biological Effects of Ionizing Radiation, National Research Council. Health risks of radon and other internally deposited alpha emitters. BEIR IV. Washington, DC: National Academy Press, 1988.

    Google Scholar 

  90. U.S. Environmental Protection Agency. A citizen’s guide to radon: What it is and what to do about it. Washington, DC: Govt Printing Office, 1986.

    Google Scholar 

  91. Samet JM, Nero AV. Sounding board: Indoor radon and lung cancer. N Engl J Med 1989;320:591–593.

    PubMed  CAS  Google Scholar 

  92. Vena JE, Byers TE, Cookfair D, Swanson M. Occupation and lung cancer risk. An analysis by histologic subtypes. Cancer (Philadelphia) 1985;56:910–917.

    CAS  Google Scholar 

  93. Saracci R. Asbestos and lung cancer: An analysis of the epidemiological evidence on the asbestos-smoking interaction. Int J Cancer 1977;20:323–331.

    PubMed  CAS  Google Scholar 

  94. Saracci R. The interactions of tobacco smoking and other agents in cancer etiology. Epidemiol Rev 1987; 9:175–193.

    PubMed  CAS  Google Scholar 

  95. Hammond EC, Selikoff IJ, Seidman H. Asbestos exposure, cigarette smoking and death rates. Ann NY Acad Sci 1979;330:473–490.

    PubMed  CAS  Google Scholar 

  96. Selikoff IJ, Hammond EC, Churg J. Asbestos exposure, smoking and neoplasia. JAMA 1968,204:106–112.

    PubMed  CAS  Google Scholar 

  97. Selikoff IJ. Asbestos and smoking. JAMA 1979;242: 458–459.

    PubMed  CAS  Google Scholar 

  98. Sluis-Cremer GK. The relationship between asbestosis and bronchial cancer. Chest 1980;78(Suppl.):380–381.

    PubMed  CAS  Google Scholar 

  99. Browne K. Is asbestos or asbestosis the cause of the increased risk of lung cancer in asbestos workers? Br J Ind Med 1986;43:145–149.

    PubMed  CAS  Google Scholar 

  100. Warnock ML, Churg AM. Association of asbestos and bronchogenic carcinoma in a population with low asbestos exposure. Cancer (Philadelphia) 1975;35:1236–1242.

    CAS  Google Scholar 

  101. Warnock ML, Kuwahara TJ, Wolery G. The relation of asbestos burden to asbestosis and lung cancer. Pathol Annu 1983; 18(Part 2): 109–145.

    PubMed  Google Scholar 

  102. Warnock ML, Isenberg W. Asbestos burden and the pathology of lung cancer. Chest 1986;89:20–26.

    PubMed  CAS  Google Scholar 

  103. Churg A. Asbestos, asbestosis, and lung cancer. Mod Pathol 1993;6:509–511.

    PubMed  CAS  Google Scholar 

  104. Roggli VL, Hammar SP, Pratt PC, Maddox JC, Legier JF, Mark EJ, Brody AR. Asbestos and lung cancer: a commentary. Am J Ind Med 1994. In Press.

    Google Scholar 

  105. Wagner JC, Berry G, Skidmore JW, Timbrell V. The effects of the inhalation of asbestos in rats. Br J Cancer 1974;29:252–269.

    PubMed  CAS  Google Scholar 

  106. Browne K. A threshold for asbestos-related lung cancer. Br J Ind Med 1986;43:556–558.

    PubMed  CAS  Google Scholar 

  107. McFadden D, Wright JL, Wiggs B, Churg A. Smoking inhibits asbestos clearance. Am Rev Respir Dis 1986; 133:372–374.

    PubMed  CAS  Google Scholar 

  108. McFadden D, Wright J. Wiggs B, Churg A. Cigarette smoke increases the penetration of asbestos fibers into airway walls. Am J Pathol 1986;123:95–99.

    PubMed  CAS  Google Scholar 

  109. Barton RTH, Hogetveit ACH. Nickel-related cancers of the respiratory tract Cancer (Philadelphia) 1980; 45:3061–3064.

    CAS  Google Scholar 

  110. Wicks MH, Archer VE, Auerbach O, Kuschner M. Arsenic exposure in a copper smelter as related to histological type of lung cancer. Am J Ind Med 1981;2:25–31.

    PubMed  CAS  Google Scholar 

  111. Smith AB, Zuzuki Y. Histopathologic classification of bronchogenic carcinomas among a cohort of workers occupationally exposed to beryllium. Environ Res 1980;21:10–14.

    PubMed  CAS  Google Scholar 

  112. Osburn HS. Lung cancer in a mining district in Rhodesia. S Afr Med J 1969;43:1307–1312.

    PubMed  CAS  Google Scholar 

  113. National Academy of Sciences. Committee on biologic effects of atmospheric pollutants. Chromium. Washington DC: Division of Medical Sciences. National Research Council, 1974:58.

    Google Scholar 

  114. Figueroa WG, Raszkowki R, Weiss W. Lung cancer in chloromethyl methyl ether workers. N Engl J Med 1973;288:1096–1097.

    PubMed  CAS  Google Scholar 

  115. Wasweiler RJ, Smith AH, Falk H, Tyroler HA. Excess lung cancer risk in a synthetic chemicals plant. Environ Health Perspect 1981;41:159–165.

    Google Scholar 

  116. Aksoy M. Different types of malignancies due to occupational exposure to benzene: A review of recent observations in Turkey. Environ Res 1980;23:181–190.

    PubMed  CAS  Google Scholar 

  117. Yamada A. On the late injuries following occupational inhalation of the mustard gas with special references to carcinoma of the respiratory tract. Acta Pathol Jpn 1963;13:131–155.

    PubMed  CAS  Google Scholar 

  118. Aksoy M. Hematotoxicity and carcinogenicity of benzene. Environ Health Perspect 1989;82:193–197.

    PubMed  CAS  Google Scholar 

  119. Yin SN, Li GL, Tain FD, et al. A retrospective cohort study of leukemia and other cancers in benzene workers. Environ Health Perspect 1989;82:207–213.

    PubMed  CAS  Google Scholar 

  120. Maltoni C, Ciiberti A, Cotti G, Conti B, Belpoggi F. Benzene, an experiment multipotential carcinogen: Results of the long-term bioassays performed at the Bologna Institute of Oncology. Environ Health Perspect 1989;82:109–124.

    PubMed  CAS  Google Scholar 

  121. Dubrow R, Wegman D. Setting priorities for occupational cancer research and control: Synthesis of the results of occupational disease surveillance studies. J Natl Cancer Inst 1983;7l: 1123–1142.

    Google Scholar 

  122. Morabia A, Markowitz S, Garibaldi K. Wynder EL. Lung cancer and occupation: Results of a multicentre case-control study. Br J Ind Med 1992;49:721–727.

    PubMed  CAS  Google Scholar 

  123. Burns PB, Swanson GM. The occupational cancer incidence surveillance sutdy (OCISS): Risk of lung cancer by usual occupation and industry in the Detroit metropolitan area. Am J Ind Med 1991;19:655–671.

    PubMed  CAS  Google Scholar 

  124. Guberan E, Usel M, Raymond L, Bolay J, Fioretta G, Puissant J. Increased risk for lung cancer and for cancer of the gastrointestinal tract among Geneva professional drivers. Br J Ind Med 1992;49:337–344.

    PubMed  CAS  Google Scholar 

  125. Yousem SA, Ohori P, Sonmez-Alpan E. Occurrence of human papilloma virus DNA in primary lung neoplasms. Cancer (Philadelphia) 1992;69:693–697.

    CAS  Google Scholar 

  126. Kaplan MH, Susan M, Pahwa SG, et al. Neoplastic complications of HTLV-III infection: Lymphomas and solid tumors. Am J Med 1987;82:389–396.

    PubMed  CAS  Google Scholar 

  127. Monfardini S, Vaccher E, Pizzacaro G, et al. Unusual malignant tumors in 49 patients with HIV infection. AIDS 1989;3:449–452.

    PubMed  CAS  Google Scholar 

  128. Braun MA, Killan DA, Remick SC, Ruckdeschel JC. Lung cancer in HIV seropositive patients. Radiology 1990:175:341–343.

    PubMed  CAS  Google Scholar 

  129. Remick SC, Harper GR, Abdullah MA, McSharry JJ, Ross JS, Ruckdeschel JC. Metastatic breast cancer in a young seropositive patient. J Natl Cancer Inst 1991;83:447–448.

    PubMed  CAS  Google Scholar 

  130. Sridhar KS, Flores MR, Raub WA, Jr., Saldana M. Lung cancer in patients with human immunodeficiency virus infection compared with historic control subjects. Chest 1992;102:1704–1708.

    PubMed  CAS  Google Scholar 

  131. Remick SC. Lung cancer: An HIV-related neoplasm or a coincidental finding? Chest 1992;106:1643–1644.

    Google Scholar 

  132. Markman M, Braine HG, Abeloff MD. Histocompatibility antigens in small cell carcinoma of the lung. Cancer (Philadelphia) 1984;54:2943–2945.

    CAS  Google Scholar 

  133. Whang-Peng J, Kao-Shan CS, Bunn PA, Carney DN, Gazdar AF, Minna JD. Specific chromosome defect association with human small-cell lung cancer: Deletion 3p(14–23). Science 1982;215:181–182.

    PubMed  CAS  Google Scholar 

  134. Tokuhata GK, Lilienfeld AM. Familial aggregation of lung cancer in humans. J Natl Cancer Inst 1963; 30:289–312.

    PubMed  CAS  Google Scholar 

  135. Ooi WL, Elston Rch Chen VW, Bailey-Wilson JE, Rothschild H. Increased familial risk for lung cancer. J Natl Cancer Inst 1986;76:217–222.

    PubMed  CAS  Google Scholar 

  136. Sellers TA, Ooi WL, Elston RC, Chen VW, Bailey-Wilson JE, Rothschild H. Increased familial risk for non-lung cancer among relatives of lung cancer patients. Am J Epidemiol 1987;126:237–246.

    PubMed  CAS  Google Scholar 

  137. Lynch HT, Kimberling WJ, Markvicka SE, et al. Genetics and smoking-associated cancers. Cancer (Philadelphia) 1986:57:1640–1644.

    CAS  Google Scholar 

  138. Samet JM, Humble CG, Pathak DR. Personal and family history of respiratory disease and lung cancer risk. Am Rev Respir Dis 1986;134:466–470.

    PubMed  CAS  Google Scholar 

  139. McDuffie HH. Clustering of cancer in families of patients with primary lung cancer. J Clin Epidemiol 1991;44:69–76.

    PubMed  CAS  Google Scholar 

  140. Shaw GL, Falk RT, Pickle LW, Mason TJ, Buffler PA. Lung cancer risk associated with cancer in relatives. J Clin Epidemiol 1991;44:429–437.

    PubMed  CAS  Google Scholar 

  141. Sellers TA, Elston RC, Atwood LD, Rothschild H. Lung cancer histologic type and family history of cancer. Cancer (Philadelphia) 1992;69:86–91.

    CAS  Google Scholar 

  142. Peto R, Doll R, Buckley JD, et al. Can dietary beta-carotene materially reduce human cancer rates? Nature (London) 1981;290:201–208.

    CAS  Google Scholar 

  143. Goodman GE, Omenn GS, Feigel P, et al. Chemoprevention of lung cancer with retinol/beta-carotene. In: Meyskens FL, Prasad KN, eds. Vitamins and cancer: Human cancer prevention by vitamins and micronutrients. Clifton, NJ: Humana Press, 1985:341–350.

    Google Scholar 

  144. Menkes MS, Comstock GW, Vuillenmier JP, et al. Serum beta carotene, vitamins A and E, selenium, and risk of lung cancer. N Engl J Med 1986;315:1250–1254.

    PubMed  Google Scholar 

  145. Ziegler RG, Mason TJ, Stemhagen A, et al. Carotenoid intake, vegetables, and the risk of lung cancer among white men in New Jersey. Am J Epidemiol 1986; 123:1080.

    PubMed  CAS  Google Scholar 

  146. Mathews-Roth MM. Carotenoids and cancer prevention—experimental and epidemiologic studies. Pure Appl Chem 1985;57:717–722.

    CAS  Google Scholar 

  147. Kroes R, Beems RB, Bosland MC, et al. Nutritional factors in lung, colon, and prostate carcinogenesis in animal models. Fed Proc 1986;45:136–1451.

    PubMed  CAS  Google Scholar 

  148. Stich H, Rosin M, Vallejera M. Reduction with vitamin A and beta-carotene administration of proportion of micronucleate buccal mucosal cells in Asian betel nut and tobacco chewers. Lancet 1984;i: 1204–1206.

    Google Scholar 

  149. Bertram JS, Pung A, Churley M, Kappock TJ, Wilkins LR, Cooney RY. Diverse carotenoids protect against chemically induced neoplastic transformation. Carcinogenesis 1991;12:671–678.

    PubMed  CAS  Google Scholar 

  150. Sestili MA. Chemoprevention clinical trials: Problems and Solutions. Publ. 85-2715. Bethesda: National Institutes of Health, 1984.

    Google Scholar 

  151. Weiss W, Seidman H, Boucot K. The Philadelphia pulmonary neoplasm research project: thwarting factors in periodic screening for lung cancer. Am Rev. Respir Dis 1975;111:289–297.

    PubMed  CAS  Google Scholar 

  152. Nash FA, Morgan JM, Tomkins JG. South London cancer study. Br Med J 1968;2:715–721.

    PubMed  CAS  Google Scholar 

  153. ACS report on the cancer-related checkup: cancer of the lung; Appendix B: Experimental biases. CA Bull Cancer Prog 1980;30:199–207.

    Google Scholar 

  154. Brett GZ. Earlier diagnosis and survival in lung cancer. Br Med J 1969;4:260–262.

    PubMed  CAS  Google Scholar 

  155. Frost JK, Ball WC, Levin ML, et al. Early lung cancer detection: Results of the initial (prevalence) radiologic and cytologic screening in the Johns Hopkins study. Am Rev Respir Dis 1984;130:549–554.

    PubMed  CAS  Google Scholar 

  156. Flehinger BJ, Melamed MR, Zaman MB, Heelan RT, Perchick WB, Martini N. Early lung cancer detection: Results of the initial (prevalence) radiologic and cytologic screening in the Memorial Sloan-Kettering study. Am Rev Respir Dis 1984;130:555–560.

    PubMed  CAS  Google Scholar 

  157. Fontana RS, Sanderson DR, Taylor WF, et al. Early lung cancer detection: Results of the initial (prevalence) radiologic and cytologic screening in the Mayo Clinic study. Am Rev Respir Dis 1984;130:561–565.

    PubMed  CAS  Google Scholar 

  158. Bailar JC, Screening for lung cancer—where are we now? Am Rev Respir Dis 1984;130:541–542.

    PubMed  Google Scholar 

  159. Weiss W. Screening for lung cancer. Chest 1985; 87:273–274.

    PubMed  CAS  Google Scholar 

  160. Merz B. Is screening for early lung cancer worthwhile? JAMA 1983;249:1537–1538.

    PubMed  CAS  Google Scholar 

  161. Fontana RS, Sanderson DR, Woolner LB, et al. Screening for lung cancer: A critique of the Mayo Lung Project. Cancer (Philadelphia) 1991;67:1155–1164.

    CAS  Google Scholar 

  162. Dreis DF. Screening for lung cancer: Do chest x-rays save lives or waste money? Bull Mason Clin 1985; 39:113–121.

    Google Scholar 

  163. Feld R, Rubinstein LV, Weisenberger TH, and the Lung Cancer Study Group. Sites of recurrence in resected stage 1 non-small cell lung cancer: A guide for future studies. J Clin Oncol 1984;2:1352–1358.

    PubMed  CAS  Google Scholar 

  164. Li W, Hammar SP, Jolly PC, Hill LD, Anderson RP. Unpredictable course of small cell undifferentiated lung carcinoma. J Thorac Cardiovasc Surg 1981;81: 34–43.

    PubMed  CAS  Google Scholar 

  165. Carr DT, Mountain CF. Staging of lung cancer. Semin Respir Med 1982;3:154–163.

    Google Scholar 

  166. Naruke T, Suemasu K, Ishikawa S. Lymph node mapping and curability at various levels of metastasis in resected lung cancer. J Thorac Cardiovasc Surg 1978;76:832–839.

    PubMed  CAS  Google Scholar 

  167. Mountain CF. A new international staging system for lung cancer. Chest 1986;89(Suppl):225S–233S.

    PubMed  CAS  Google Scholar 

  168. Mountain CF, Greenberg SD, Fraire AE. Tumor stage in non-small cell carcinoma of the lung. Chest 1991;99:1258–1260.

    PubMed  CAS  Google Scholar 

  169. Fernando HC, Goldstraw P. The accuracy of clinical evaluative intrathoracic staging in lung cancer as assessed by post-surgical pathologic staging. Cancer (Philadelphia) 1990;65:2503–2506.

    CAS  Google Scholar 

  170. Bulzebruck H, Bopp R, Drings P, et al. New aspects in the staging of lung cancer: Prospective validation on the international union against cancer TNM classification. Cancer (Philadelphia) 1992;70:1102–1110.

    CAS  Google Scholar 

  171. Tisi GM, Friedman PJ, Peters RM, et al. Clinical staging of primary lung cancer. Am Rev Respir Dis 1983;127:659–664.

    Google Scholar 

  172. Decker DA, Dines DE, Payne WS, et al. The significance of a cytologically negative pleural effusion in bronchogenic carcinoma. Chest 1978;74:640–642.

    PubMed  CAS  Google Scholar 

  173. Grillo HC. Carinal reconstruction. Ann Thorac Surg 1982;34:356–373.

    PubMed  CAS  Google Scholar 

  174. Sartori F. Right upper tracheal sleeve lobectomy for carcinoma of the lung. Reconstruction of tracheal bifurcation. Minerva Chir 1984;39:209–212.

    PubMed  CAS  Google Scholar 

  175. Gilbert A, Deslauriers J, McLish A, Piraux M. Tracheal sleeve pneumonectomy for carcinoma of the proximal left main bronchus. Can J Surg 1984;27:583–585.

    PubMed  CAS  Google Scholar 

  176. The World Health Organization histological typing of lung tumors. 2d Ed. Am J Clin Pathol 1982;77:123–136.

    Google Scholar 

  177. Watkin SW. Temporal demographic and epidemiologic variation in histologic subtypes of lung cancer: A literature review. Lung Cancer 1989;5:69–81.

    Google Scholar 

  178. Kung ITM, So KF, Lum TH. Lung cancer in Hong Kong Chinese: Mortality and histologic types 1973–1982. Br J Cancer 1984;50:381–388.

    PubMed  CAS  Google Scholar 

  179. Whitwell F. The histopathology of lung cancer in Liverpool: The specificity of the histological cell types of lung cancer. Br J Cancer 1961;15:440–459.

    PubMed  CAS  Google Scholar 

  180. Feinstein AR, Gelfman NA, Yesner R. Observer variability in the histopathologic diagnosis of lung cancer. Am Rev Respir Dis 1970;101:671–684.

    PubMed  CAS  Google Scholar 

  181. Stanley KE, Matthews MJ. Analysis of a pathology review of patients with lung tumours. J Natl Cancer Inst 1981;66:989–992.

    PubMed  CAS  Google Scholar 

  182. Vincent RG, Pickren JW, Lane WW, et al. The changing histopathology of lung cancer: A review of 1682 cases. Cancer (Philadelphia) 1977;39:1647–1565.

    CAS  Google Scholar 

  183. Larsson S. Completeness and reliability of lung cancer registration in the Swedish Cancer Registry. Acta Pathol Microbiol Scand A Pathol 1971;79:389–398.

    CAS  Google Scholar 

  184. El-Torky M, El-Zeky F, Hall JC. Significant changes in the distribution of histologic types of lung cancer: A review of 4928 cases. Cancer (Philadelphia) 1990; 65:2361–2367.

    CAS  Google Scholar 

  185. Auerbach O, Garfinkel L. The changing pattern of lung carcinoma. Cancer (Philadelphia) 1991;68:1973–1977.

    CAS  Google Scholar 

  186. Morabia A, Wynder EL. Cigarette smoking and lung cancer cell types. Cancer (Philadelphia) 1991;68: 2074–2078.

    CAS  Google Scholar 

  187. Yesner R. Spectrum of lung cancer and ectopic hormones. Pathol Annu 1978;13(Part I):2l7–240.

    Google Scholar 

  188. Adelstein DJ, Tomahefski JF, Snow NJ, Horrigan JP, Hines JD. Mixed small cell and non-small cell lung cancer. Chest 1986;89:699–704.

    PubMed  CAS  Google Scholar 

  189. Roggli VL, Volmer RT, Greenberg SD, McGavran MH, Spjut HJ, Yesner R. Lung cancer heterogeneity: A blinded and randomized study of 100 consecutive cases. Hum Pathol 1985;16:569–579.

    PubMed  CAS  Google Scholar 

  190. Keehn R, Auerbach O, Nambu S, et al. Reproducibility of major diagnoses in a binational study of lung cancer in uranium miners and atomic bomb survivors. Am J Clin Pathol 1994;101:478–482.

    PubMed  CAS  Google Scholar 

  191. Martini N, Melamed MR. Multiple primary lung cancers. J Thorac Cardiovasc Surg 1975;70:606–612.

    PubMed  CAS  Google Scholar 

  192. Razzuk MA, Pockey M. Urschel HC, Paulson DL. Dual primary bronchogenic carcinoma. Ann Thorac Surg 1974;17:425–433.

    PubMed  CAS  Google Scholar 

  193. Rohwedder JJ, Weatherbee L. Multiple primary bronchogenic carcinoma. Ann Thorac Surg 1974; 17:425–433.

    Google Scholar 

  194. Warren S, Gates O. Multiple primary malignant tumors: a survey of the literature and a statistical study. Am J Cancer (Philadelphia) 1932;16:1358–1414.

    Google Scholar 

  195. Auerbach O, Stout AP, Hammond EC, Garfinkel L. Multiple primary bronchial carcinomas. Cancer (Philadelphia) 1967;20:699–705.

    CAS  Google Scholar 

  196. Struve-Christensen E. Diagnosis and treatment of bilateral primary bronchogenic carcinoma. J Thorac Cardiovasc Surg 1971;61:501–513.

    PubMed  CAS  Google Scholar 

  197. Jung-Legg Y, McGowan SF, Sweeney KG, Zitzman JL, Pugntch RP. Synchronous triple malignant tumors of the lung: A case report of bronchial carcinoid, small cell carcinoma, and adenocarcinoma of the right lung. Am J Clin Pathol 1986;85:96–101.

    PubMed  CAS  Google Scholar 

  198. Wu S, Lin Z, Xu C, Koo K, Huang O, Xie D. Multiple primary lung cancers. Chest 1987;92:892–896.

    PubMed  CAS  Google Scholar 

  199. Deschamps C, Pairolero PC, Trastek VF, Payne WS. Multiple primary lung cancers: results of surgical treatment. J Thorac Cardiovasc Surg 1990;99:769–778.

    PubMed  CAS  Google Scholar 

  200. Seydel HG, Chait A, Gmelich JT. The natural history of cancer of the lung. In: Seydel HG, Chait A, Gmelich JT, eds. Cancer of the lung. New York: Wiley, 1975:52–63.

    Google Scholar 

  201. Auerbach O. Natural history of carcinoma of the lung. In: Fishman AP, ed. Pulmonary diseases and disorders. New York: McGraw-Hill, 1980; 1388–1396.

    Google Scholar 

  202. Miller YE. Growth factors, oncogenes and lung cancer. Am Rev Respir Dis 1985;132:178–179.

    PubMed  CAS  Google Scholar 

  203. Wick MR. Oncogene analysis in diagnostic pathology: A current perspective. Am J Clin Pathol 1992; 97(Suppl. 1):S1-S3.

    PubMed  CAS  Google Scholar 

  204. Viallet J, Minna JD. Dominant oncogenes and tumor suppressor genes in the pathogenesis of lung cancer. Am J Respir Cell Mol Biol 1990;2:225–232.

    PubMed  CAS  Google Scholar 

  205. Damstrup L, Rorth M, Poulsen HS. Growth factors and growth factor receptors in human malignancies with special reference to lung cancer: a review. Lung Cancer 1989;5:49–68.

    Google Scholar 

  206. Paul J. Oncogenesis. In: Anthony PP, MacSween RNM, eds. Recent advances in histopathology. London: Churchill-Livingstone, 1987:13–31.

    Google Scholar 

  207. Collins VP, Loeffler RK, Tivey H. Observations on growth rates of human tumors. Am J Roentgenol Radium Ther Nucl Med 1956;76:988–1000.

    PubMed  CAS  Google Scholar 

  208. Geddes DM. The natural history of lung cancer: A review based on rates of tumour growth. Br J Dis Chest 1979;73:1–17.

    PubMed  CAS  Google Scholar 

  209. Brenner MW, Holsti LR, Pertolla Y. The study of graphical analysis of the growth of human tumours and metastases of the lung. Br J Cancer 1967; 1–13.

    Google Scholar 

  210. Breuer K. Growth rate and radiosensitivity of human tumours. Europ J Cancer 1966;2:157–171.

    Google Scholar 

  211. Chahinian P. Relationship between tumour doubling time and anatomoclinical features in 50 measurable pulmonary cancers. Chest 1972;61:340–345.

    PubMed  CAS  Google Scholar 

  212. Garland LH, Coulson W, Wollin E. The rate of growth and apparent duration of untreated primary bronchial carcinoma. Cancer, N.Y., 1963;16:694–707.

    PubMed  CAS  Google Scholar 

  213. Garland LH. The rate of growth and apparent duration of primary bronchial cancer. Am J Roent Rad Ther 1966;96:604–611.

    CAS  Google Scholar 

  214. Meyer JA. Growth rate versus prognosis in resected primary bronchogenic cancer. Cancer, N.Y., 1973; 31:1468–1472.

    PubMed  CAS  Google Scholar 

  215. Schwartz M. A biomathematical approach to clinical tumour growth. Cancer, N.Y., 1961;14:1272–1294.

    PubMed  CAS  Google Scholar 

  216. Steele JD, Buell P. A symptomatic solitary pulmonary nodules. J Thorac Cardiovasc Surg 1973;65:140–151.

    PubMed  CAS  Google Scholar 

  217. Weiss W, Boucot KR, Cooper DA. Growth rate in the detection and prognosis of bronchogenic carcinoma. JAMA 1966;198:1246–1256.

    PubMed  CAS  Google Scholar 

  218. Weiss W. Tumour doubling time and survival of men with bronchogenic carcinoma. Chest 1974;65:3–8.

    PubMed  CAS  Google Scholar 

  219. Chahinian P, Israel L. Rates and patterns of growth of lung cancer. In: Israel L, Chahinian P, eds. Lung cancer: Natural history, prognosis and therapy. New York: Academic Press, 1976:63–79.

    Google Scholar 

  220. Chahinian P, Israel L. Prognostic value of doubling times and related factors in lung cancer. In: Israel L, Chahinian P, eds, Lung cancer: Natural history, prognosis and therapy. New York: Academic Press, 1976:95–106.

    Google Scholar 

  221. Nathan MH, Collins VP, Adams RA. Differentiation of benign and malignant pulmonary nodules by growth rates. Radiology 1962;79:221–231.

    PubMed  CAS  Google Scholar 

  222. Kerr KM, Lamb D. Actual growth rate and tumour cell proliferation in human pulmonary neoplasms. Br J Cancer 1984;50:343–349.

    PubMed  CAS  Google Scholar 

  223. Greengard O, Head JF, Goldberg SL, Kirschner PA. Biochemical measure of the volume doubling time of human pulmonary neoplasms. Cancer (Philadelphia) 1985;55:1530–1535.

    CAS  Google Scholar 

  224. Byrd RB, Miller WE, Carr DT. The roentgenographic appearance of squamous cell carcinoma of the bronchus. Mayo Clin Proc 1968;43:327–332.

    PubMed  CAS  Google Scholar 

  225. Walter JB, Pryce DM. The site of origin of lung cancer and its relation to histological type. Thorax 1955;10:117–126.

    PubMed  CAS  Google Scholar 

  226. Chaudhuri MR. Primary pulmonary cavitating carcinomas. Thorax 1973;28:354–366.

    PubMed  CAS  Google Scholar 

  227. Dulmet-Brender E, Jaubert F, Huchon G. Exophytic endobronchial epidermoid carcinoma. Cancer (Philadelphia) 1986;57:1358–1364.

    CAS  Google Scholar 

  228. Carter D, Eggleston JC. Squamous cell carcinoma. In: Tumors of the lower respiratory tract (Atlas of tumor pathology, 2d Ser., Fasc. 17). Washington DC: Armed Forces Institute of Pathology 1980;70–94.

    Google Scholar 

  229. Trump BF, McDowell EM, Glavin F, et al. The respiratory epithelium. III. Histogenesis of epidermoid metaplasia and carcinoma in situ in the human. J Natl Cancer Inst 1978;61:563–575.

    PubMed  CAS  Google Scholar 

  230. Yamamoto M, Shimokata K, Nagura H. Immunoelectron microscopic study on the histogenesis of epidermoid metaplasia in respiratory epithelium. Am Rev Respir Dis 1987;135:713–718.

    PubMed  CAS  Google Scholar 

  231. Valaitis J, Warren S, Gamble D. Increasing incidence of adenocarcinoma of the lung. Cancer (Philadelphia) 1981;47:1042–1046.

    CAS  Google Scholar 

  232. Taylor AB, Shinton NH, Waterhouse JAH. Histology of bronchial carcinoma in relation to prognosis. Thorax 1963;18:178–181.

    PubMed  CAS  Google Scholar 

  233. Weiss W, Boucot KR, Cooper DA. The histopathology of bronchogenic carcinoma and its relation to growth rate, metastasis, and prognosis. Cancer (Philadelphia) 1970;26:965–970.

    CAS  Google Scholar 

  234. Ashley DJB, Davies HD. Cancer of the lung: Histology and biological behaviour. Cancer (Philadelphia) 1967; 20:165–174.

    CAS  Google Scholar 

  235. Bennett DE, Sasser WR, Ferguson TB. Adenocarcinoma of the lung in men: A clinicopathologic study of 100 cases. Cancer (Philadelphia) 1969;23:431–439.

    CAS  Google Scholar 

  236. Sorensen JB, Hirsch FR, Gazdar A, Olsen JE. Interobserver variability in histopathologic subtyplng and grading of pulmonary adenocarcinoma. Cancer 1993;71: 2971–2976.

    PubMed  CAS  Google Scholar 

  237. Raeburn C, Spencer H. A study of the origin and development of lung cancer. Thorax 1953;8:1–10.

    PubMed  CAS  Google Scholar 

  238. Raeburn C, Spencer H. Lung scar cancers. Br J Tuberc Dis Chest 1957;51:237–245.

    PubMed  CAS  Google Scholar 

  239. Carroll R. Influence of lung scars on primary lung cancer. J Pathol Bacteriol 1962;83:293–297.

    PubMed  CAS  Google Scholar 

  240. Auerbach O, Garfinkel L, Parks VR. Scar cancer of the lung: Increase over a 21-year period. Cancer (Philadelphia) 1979;43:636–642.

    CAS  Google Scholar 

  241. Scannell JG. “Bleb” carcinoma of the lung. J Thorac Cardiovasc Surg 1980;80:904–908.

    PubMed  CAS  Google Scholar 

  242. Konwaler BE, Reingold IM. Carcinoma arising in bronchiectatic cavities. Cancer (Philadelphia) 1952; 5:525–529.

    CAS  Google Scholar 

  243. Shimosato Y, Hashimoto T, Kodama T, et al. Prognostic implications of fibrotic focus (scar) in small peripheral lung cancers. Am J Surg Pathol 1980;4:365–373.

    PubMed  CAS  Google Scholar 

  244. Madri JA, Carter D. Scar cancers of the lung: Origin and significance. Hum Pathol 1984;15:625–631.

    PubMed  CAS  Google Scholar 

  245. Kung ITM, Lui IOL, Loke SL, et al. Pulmonary scar cancer: A pathologic reappraisal. Am J Surg Pathol 1985;9:391–400.

    PubMed  CAS  Google Scholar 

  246. Cagle PT, Cohle SD, Greenberg SD. Natural history of pulmonary scar cancers: Clinical and pathologic implications. Cancer (Philadelphia) 1985;56:2031–2035.

    CAS  Google Scholar 

  247. Barsky SH, Huang SJ, Bhuta S. The extracellular matrix of pulmonary scar carcinomas is suggestive of a desmoplastic origin. Am J Pathol 1986;124:412–419.

    PubMed  CAS  Google Scholar 

  248. Kolin A, Kovtovlakis T. Invasion of pulmonary arteries by bronchial carcinomas. Hum Pathol 1987; 18:1165–1171.

    PubMed  CAS  Google Scholar 

  249. Kolin A, Kovtovlakis T. Role of arterial occlusion in pulmonary scar cancers. Hum Pathol 1988; 19:1161–1167.

    PubMed  CAS  Google Scholar 

  250. Meyer EC, Liebow AA. Relationship of interstitial pneumonia honeycombing and atypical epithelial proliferation to cancer of the lung. Cancer (Philadelphia) 1965;218:322–351.

    Google Scholar 

  251. Fox B, Ridson RA. Carcinoma of the lung and diffuse interstitial pulmonary fibrosis. J Clin Pathol 1968;21: 486–491.

    PubMed  CAS  Google Scholar 

  252. Haddad R, Massaro D. Idiopathic diffuse interstitial pulmonary fibrosis (fibrosing alveolitis), atypical epithelial proliferation and lung cancer. Am J Med 1968;45:211–219.

    PubMed  CAS  Google Scholar 

  253. Fraire AE, Greenberg SD. Carcinoma and diffuse interstitial fibrosis of lung. Cancer 1973;31:1078–1086.

    PubMed  CAS  Google Scholar 

  254. Turner-Warwick M, Lebowitz M, Burrows B, Johnson A. Cryptogenic fibrosing alveolitis and lung cancer. Thorax 1980;35:496–499.

    PubMed  CAS  Google Scholar 

  255. Zatuchni J, Campbell WN, Zarafonetis CJD. Pulmonary fibrosis and terminal bronchiolar (‘alveolar cell’) carcinoma in scleroderma. Cancer (Philadelphia) 1953;6:1147–1158.

    CAS  Google Scholar 

  256. Collins DH, Darke CS, Dodge OG. Scleroderma with honeycomb lung and bronchiolar carcinoma. J Pathol Bacteriol 1958;76:531–540.

    PubMed  CAS  Google Scholar 

  257. Caplan H. Honeycomb lungs and malignant pulmonary adenomatosis in scleroderma. Thorax 1959; 14:89–96.

    PubMed  CAS  Google Scholar 

  258. Montgomery RD, Stirling GA, Hamer NAJ. Bronchiolar carcinoma in progressive systemic sclerosis. Lancet 1962;iii:693–695.

    Google Scholar 

  259. Liebow AA. Bronchiolo-alveolar carcinoma. Adv Intern Med 1960;10:329–358.

    PubMed  CAS  Google Scholar 

  260. Rosenblatt MB, Lisa JR, Collier F. Primary and metastatic bronchiolo-alveolar carcinoma. Dis Chest 1967; 52;147–152.

    PubMed  CAS  Google Scholar 

  261. Clayton F. Bronchioloalveolar carcinomas: cell types, patterns of growth, and prognostic correlates. Cancer (Philadelphia) 1986;57:1555–1564.

    CAS  Google Scholar 

  262. Clayton F. The spectrum and significance of bronchioloalveolar carcinomas. Pathol Annu 1988;23:361–394.

    PubMed  Google Scholar 

  263. Adamson JS, Senior RM, Merrill T. Alveolar cell carcinoma: an electron microscopic study. Am Rev Respir Dis 1969;100:550–557.

    PubMed  CAS  Google Scholar 

  264. Coalson JJ, Mohr JA, Pirtle JK, Dee AL, Rhoades ER. Electron microscopy of neoplasms in the lung with special emphasis on the alveolar cell carcinoma. Am Rev Respir Dis 1970;101:181–197.

    PubMed  CAS  Google Scholar 

  265. Kuhn C. Fine structure of bronchiolo-alveolar cell carcinoma. Cancer (Philadelphia) 1972;30:1107–1118.

    CAS  Google Scholar 

  266. Nash G, Langlinais PC, Greenwald KA. Alveolar cell carcinoma: Does it exist? Cancer (Philadelphia) 1972; 29:322–326.

    CAS  Google Scholar 

  267. Bedrossian CWM, Weilbaecher DG, Bentinck DC, Greenberg SD. Ultrastructure of human bronchiolo-alveolar cell carcinoma. Cancer (Philadelphia) 1975; 36:1399–1413.

    CAS  Google Scholar 

  268. Bonikos DS, Hendrickson M, Bensch KG. Pulmonary alveolar cell carcinoma. Fine structural and in vitro study of a case and critical review of this entity. Am J Surg Pathol 1977;1:93–108.

    PubMed  CAS  Google Scholar 

  269. Sidhu GS, Forrester EM. Glycogen-rich Clara cell-type bronchiolo-alveolar cell carcinoma. Light and electron microscopic study. Cancer (Philadelphia) 1977;40: 2209–2215.

    CAS  Google Scholar 

  270. Kimula Y. A histochemical and ultrastructural study of adenocarcinoma of the lung. Am J Surg Pathol 1978; 2:253–264.

    PubMed  CAS  Google Scholar 

  271. Morningstar WA, Hassan MO. Bronchiolo-alveolar cell carcinoma with nodal metastases Am J Surg Pathol 1979;3:273–278.

    PubMed  CAS  Google Scholar 

  272. Carter D, Eggleston JC. Bronchioloalveolar carcinoma. In: Tumors of the lower respiratory tract (Atlas of tumor pathology, 2d Ser., Fasc. 17). Washington, DC: Armed Forces Institute of Pathology, 1980:127–147.

    Google Scholar 

  273. Hammar SP, Bolen JW, Bockus D, Remington F, Friedman S. Ultrastructural and immunohistochemical features of common lung tumors: An overview. Ultrastruct Pathol 1985;9:283–318.

    PubMed  CAS  Google Scholar 

  274. Clayton F. Bronchioloalveolar carcinomas: cell types, patterns of growth, and prognostic correlates. Cancer (Philadelphia) 1986;57:1555–1564.

    CAS  Google Scholar 

  275. Herrera GA, Alexander CB, deMoraes HP. Ultrastructural subtypes of pulmonary adenocarcinoma. Correlation with patient survival. Chest 1983;84:581–586.

    PubMed  CAS  Google Scholar 

  276. Dekmezian R, Ordonez NG, Mackay B. Bronchioloalveolar adenocarcinoma with myoepithelial cells. Cancer (Philadelphia) 1991;67:2356–2360.

    CAS  Google Scholar 

  277. Torikata C, Ishiwata K. Intranuclear tubular structures observed in the cells of alveolar cell carcinomas of the lung. Cancer (Philadelphia) 1977;40:1194–1201.

    CAS  Google Scholar 

  278. Singh G, Katyal SL, Torikata C. Carcinoma of type II pneumocytes: Immunodiagnosis of a subtype of bronchioloalveolar carcinoma. Am J Pathol 1981; 102:195–208.

    PubMed  CAS  Google Scholar 

  279. Singh G, Katyal SL, Torikata C. Carcinoma of type II pneumocytes: PAS staining as a screening test for nuclear inclusions of surfactant-specific appoprotein. Cancer (Philadelphia) 1982;50:946–948.

    CAS  Google Scholar 

  280. Ghadially FN, Harawi S, Khan W. Diagnostic ultra-structural markers in alveolar cell carcinoma. J Submi-croscCytol 1985;17:269–278.

    CAS  Google Scholar 

  281. Singh G, Scheithauer BW, Katyal S. The pathobiologic features of carcinomas of type II penumocytes. Cancer (Philadelphia) 1986;57:994–999.

    CAS  Google Scholar 

  282. Hammar S, Bockus D, Remington F. Metastatic tumors of unknown origin. Ultrastruct Pathol 1986; 10:281–288.

    PubMed  CAS  Google Scholar 

  283. Basset F, Soler P, Wyllie L, et al. Langerhans cells in a bronchioloalveolar tumor of lung. Virchow Arch [Pathol Anat] 1974;362:315–330.

    CAS  Google Scholar 

  284. Hammar SP, Bockus D, Remington F, et al. Langerhans cells and serum precipitating antibodies against fungal antigen in bronchioloalveolar cell carcinomas; possible association with eosinophilic granuloma. Ultrastruct Pathol 1980; 1:19–37.

    PubMed  CAS  Google Scholar 

  285. Hammar SP, Bockus D, Remington F, Bartha M. The widespread distribution of Langerhans cells in pathologic tissues: An ultrastructural and immunohis-tochemical study. Hum Pathol 1986;17:894–905.

    PubMed  CAS  Google Scholar 

  286. Takakura H, Hirohashi S, Shimosato Y, et al. Immuno-morphologic responses of regional lymph nodes and prognosis in patients with stage I-A peripheral bronchial adenocarcinoma. Jpn J Cancer Clin 1983;29: 777–785.

    CAS  Google Scholar 

  287. Furukawa T, Watanabe S, Kodoma T, Sato Y, Shimosato Y, Suemasu K. T-zone histiocytes in adenocarcinoma of lung in relation to postoperative prognosis. Cancer (Philadelphia) 1985;56:2651–2656.

    CAS  Google Scholar 

  288. Nakanishi K, Kawai T, Suzuki M. Large intracytoplasmic body in lung cancer compared with Clara cell granule. Am J Clin Pathol 1987;88:472–477.

    PubMed  CAS  Google Scholar 

  289. Scroggs MW, Roggli VL, Fraire AE, Sanfilippo F. Eosinophilic intracytoplasmic globules in pulmonary adenocarcinomas: A histochemical, immunohis-tochemical and ultrastructural study of six cases. Hum Pathol 1989;20:845–849.

    PubMed  CAS  Google Scholar 

  290. Axiotis A, Jennings TA. Observations on bronchioloalveolar carcinomas with special emphasis on localized lesions: A clinicopathologic, ultrastructural and immunohistochemical study of 11 cases. Am J Surg Pathol 1988;12:918–931.

    PubMed  CAS  Google Scholar 

  291. Miller RR, Nelems B, Evans KG, Muller NL, Ostrow DN. Glandular neoplasia of the lung: A proposed analogy to colonic tumors. Cancer (Philadelphia) 1988;61:1009–1014.

    CAS  Google Scholar 

  292. Miller RR. Bronchioloalveolar cell adenomas. Am J Surg Pathol 1990;14:904–912.

    PubMed  CAS  Google Scholar 

  293. Yousem SA, Hochholzer L. Alveolar adenoma. Hum Pathol 1986;17:1066–1071.

    PubMed  CAS  Google Scholar 

  294. Travis WD, Linnoila RI, Horowitz M, et al. Pulmonary nodules resembling bronchioloalveolar carcinoma in adolescent cancer patients. Mod Pathl 1988;5:372–377.

    Google Scholar 

  295. Noguchi M, Kodama T, Shimosato Y, et al. Papillary adenoma of type II pneumocytes. Am J Surg Pathol 1986;10:134–139.

    PubMed  CAS  Google Scholar 

  296. Hegg CA, Flint A, Sing G. Papillary adenoma of the lung. Am J Clin Pathol 1992;97:393–397.

    PubMed  CAS  Google Scholar 

  297. Hammar S. Adenocarcinoma and large cell undifferentiated carcinoma of the lung. Ultrastruct Pathol 1987;11:251–274.

    PubMed  Google Scholar 

  298. Barnes L. Intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. Am J Surg Pathol 1986;20:192–202.

    Google Scholar 

  299. Afzelius BA. Glycocalyx and glycocalyceal bodies in the respiratory epithelium of nose and bronchi. Ultrastruct Pathol 1984;7:1–8.

    PubMed  CAS  Google Scholar 

  300. Kish JK, Ro JY, Ayala AG, McMurtrey MJ. Primary mucinous adenocarcinoma of the lung with signet-ring cells: A histochemical comparison with signet-ring cell carcinomas of other sites. Hum Pathol 1989;20:1097–1102.

    PubMed  CAS  Google Scholar 

  301. Graeme-Cook F, Mark EJ. Pulmonary mucinous tumors of borderline malignancy. Hum Pathol 1991;22:185–190.

    PubMed  CAS  Google Scholar 

  302. Higashiyama M, Doi O, Kodama K. Yokouchi H, Tateishi R. Cystic mucinous adenocarcinomas of the lung: Two cases of cystic variant of mucus-producing lung adenocarcinoma. Chest 1992;101:763–766.

    PubMed  CAS  Google Scholar 

  303. Moran CA, Hochholzer L, Fishback N, Travis WD, Koss MN. Mucinous (so-called colloid) carcinomas of lung. Mod Pathol 1992;5:634–638.

    PubMed  CAS  Google Scholar 

  304. Tsao M, Fraser RS. Primary pulmonary adenocarcinoma with enteric differentiation. Cancer (Philadelphia) 1991;68:1754–1757.

    CAS  Google Scholar 

  305. Brambilla E, Moro D, Veale D, et al. Basal cell (basaloid) carcinoma of the lung: A new morphologic and phenotypic entity with separate prognostic significance. Hum Pathol 1992;23:993–1003.

    PubMed  CAS  Google Scholar 

  306. Kodama T, Shimosato Y, Koide T, Watanabe S, Yoneyama T. Endobronchial polypoid adenocarcinoma of the lung: Histologic and ultrastructural studies of five cases. Am J Surg Pathol 1984;8:845–854.

    PubMed  CAS  Google Scholar 

  307. Cagle PT, Alpert LC, Carmona PA. Peripheral biphasic adenocarcinoma of the lung: light microscopic and immunohistochemical findings. Hum Pathol 1992;23: 197–200.

    PubMed  CAS  Google Scholar 

  308. Upton MP, Hirohashi S, Tome Y, Miyazawa N, Suemasu K, Shimosato Y. Expression of vimentin in surgically resected adenocarcinomas and large cell carcinomas of lung. Am J Surg Pathol 1986;10:560–567.

    PubMed  CAS  Google Scholar 

  309. Jasani B, Edwards RE, Thomas ND, Gibbs AR. The use of vimentin antibodies in the diagnosis of malignant mesothelioma. Virchows Arch [Pathol Anat] 1985; 406:441–448.

    CAS  Google Scholar 

  310. Cherwitz D, Swanson, P, Drier J, Wick M. S100-protein reactivity in poorly differentiated carcinomas: An immunohistochemical comparison with malignant melanoma. Lab Invest 1987;56:13A.

    Google Scholar 

  311. Linnoila R, Jensen SM, Steinberg SM, Mulshine JL, Eggelston JC, Gazdar AF. Peripheral airway cell marker expression in non-small cell lung carcinoma. Am J Clin Pathol 1992;97:233–243.

    PubMed  CAS  Google Scholar 

  312. Delmonte VC, Alberti O, Saldiva PHN. Large cell carcinoma of the lung: Ultrastructural and immuno-histochemical features. Chest 1986;90:524–527.

    PubMed  CAS  Google Scholar 

  313. Churg A. The fine structure of large cell undifferentiated carcinoma of the lung: Evidence for its relation to squamous cell carcinomas and adenocarcinomas. Hum Pathol 1978;9:143–156.

    PubMed  CAS  Google Scholar 

  314. Horie A, Ohta M. Ultrastructural features of large cell carcinoma of the lung with reference to the prognosis in patients. Hum Pathol 1981;12:423–432.

    PubMed  CAS  Google Scholar 

  315. Leong AS. The relevance of ultrastructural examination in the classification of primary lung tumors. Pathology 1982;14:37–46.

    PubMed  CAS  Google Scholar 

  316. Albain KS, True LD, Golomb HM. Hoffman PC, Little AG. Large cell carcinoma of the lung: ultrastructural differentiation and clinicopathologic correlations. Cancer (Philadelphia) 1985;56:1618–1623.

    CAS  Google Scholar 

  317. Osborne BM, Mackay B. ButlerJJ, Ordonez NG. Large cell lymphoma with microvilluslike projections: an ultrastructural study. Am J Clin Pathol 1983;79:443–450.

    PubMed  CAS  Google Scholar 

  318. Butler AE, Colby TV, Weiss L, Lombard C. Lympho-epithelioma-like carcinoma of the lung. Am J Surg Pathol 1989;13:632–639.

    PubMed  CAS  Google Scholar 

  319. Nash G, Stout AP. Giant cell carcinoma of the lung: report of 5 cases. Cancer (Philadelphia) 1958; 11:369–376.

    CAS  Google Scholar 

  320. Hellstrom HR, Fisher ER. Giant cell carcinoma of lung. Cancer (Philadelphia) 1963;16:1080–1088.

    CAS  Google Scholar 

  321. Flanagan P, Roeckel IE. Giant cell carcinoma of the lung: Anatomic and clinical correlation. Am J Med 1964;36:214–222.

    PubMed  CAS  Google Scholar 

  322. Kallenberg F, Jaque J. Giant cell carcinoma of the lung: Clinical and pathologic assessment; comparison with other large-cell anaplastic bronchogenic carcinomas. Scand J Thorac Cardiovasc Surg 1979;13:343–346.

    PubMed  CAS  Google Scholar 

  323. Shin MS, Jackson LK, Shelton RW, Greene RE. Giant cell carcinoma of the lung: Clinical and roentgeno-graphic manifestations. Chest 1986;89:366–369.

    PubMed  CAS  Google Scholar 

  324. Ozzello L, Stout AP. The epithelial origin of giant cell carcinoma of the lung confirmed by tissue culture; report of a case. Cancer (Philadelphia) 1961; 14:1052–1056.

    CAS  Google Scholar 

  325. Wang NS, Seemayer TA, Ahmed MN, Knaack J. Giant cell carcinoma of the lung: A light and electron microscopic study. Hum Pathol 1976;7:3–16.

    PubMed  CAS  Google Scholar 

  326. Ginsberg SS, Buzaid AC, Stern H, Carter D. Giant cell carcinoma of the lung. Cancer (Philadelphia) 1992; 70:606–610.

    CAS  Google Scholar 

  327. Yesner R, Gerstl B, Auerbach O. Application of World Health Organization classification of lung carcinoma to biopsy material. Ann Thorac Surg 1965;1:33–49.

    Google Scholar 

  328. Kern WH, Jones JC, Chapman ND. Pathology of bronchogenic carcinoma in long-term survivors. Cancer (Philadelphia) 1968;21:772–780.

    CAS  Google Scholar 

  329. Auerbach O, Frasca JM, Parks VR, et al. A comparison of World Health Organization (WHO) classification of lung tumors by light and electron microscopy. Cancer (Philadelphia) 1982;50:2079–2088.

    CAS  Google Scholar 

  330. Ashley DJ, Davies HD. Mixed glandular and squamous-cell carcinoma of the bronchus. Thorax 1967;22:431–436.

    PubMed  CAS  Google Scholar 

  331. Fitzgibbons PL, Kern WH. Adenosquamous carcinoma of the lung: A clinical and pathologic study of seven cases. Hum Pathol 1985;16:463–466.

    PubMed  CAS  Google Scholar 

  332. McDowell EM, McLaughlin JS, Merenyl DK, et al. The respiratory epithelium. V. Histogenesis of lung carcinomas in the human. J Natl Cancer Inst 1978;61:587–606.

    PubMed  CAS  Google Scholar 

  333. Wilson TS, McDowell EM, Trump BF. Immunohis-tochemical studies of keratinization in human lung tumors. J Cell Biol 1981;91:299a.

    Google Scholar 

  334. Takamori S, Noguchi M, Morinaga S, Goya T, Tsugane S, Kakegawa T, Shimosato Y. Clinicopathologic characteristics of adenosquamous carcinoma of the lung. Cancer (Philadelphia) 1991;67:649–654.

    CAS  Google Scholar 

  335. Ishida T, Kaneko S, Yokoyama H, Inoue T, Sugio K, Sugimachi K. Adenosquamous carcinoma of the lung: Clinicopathologic and immunohistochemical features. Am J Clin Pathol 1992;97:678–685.

    PubMed  CAS  Google Scholar 

  336. Yousem SA. Pulmonary adenosquamous carcinomas with amyloid-like stroma. Mod Pathol 1989;2:420–426.

    PubMed  CAS  Google Scholar 

  337. Feyrter F. Ueber diffuse endokrine epitheliate organe. Zentralbl Inn Med 1938;59:545–561.

    Google Scholar 

  338. Pearse AGE. The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologie, physiologic and pathologic implications of this concept. J Histochem Cytochem 1969;17:303–313.

    PubMed  CAS  Google Scholar 

  339. Pearse AGE, Takor Takor T. Embyrology of the diffuse neuroendocrine system and its relationship to the common peptides. Fed Proc 1979;38:2288–2294.

    PubMed  CAS  Google Scholar 

  340. Pearse AGE. The diffuse neuroendocrine system: an extension of the APUD concept. In: Taylor S, ed. Endocrinology. London: Heinemann, 1972:145.

    Google Scholar 

  341. Gould VE, DeLellis RA. The neuroendocrine cell system: its tumors, hyperplasias, and dysplasias. In: Silverberg SG, ed. Principles and practice of surgical pathology. New York: Wiley, 1983:1488–1501.

    Google Scholar 

  342. Gould VE, Moll R, Moll I, Lee I, Franke WW. Neuroendocrine (Merkel) cells of the skin: hyperplasias dysplasias and neoplasms. Lab Invest 1985;52:334–353.

    PubMed  CAS  Google Scholar 

  343. Gould VE, Linnoila RI, Memoli VA, Warren WH. Neuroendocrine components of the bronchopulmonary tract: Hyperplasias, dysplasias, and neoplasms. Lab Invest 1983;49:519–537.

    PubMed  CAS  Google Scholar 

  344. Gould VE, Wiedenmann B, Lee I, et al. Synaptophysin expression in neuroendocrine neoplasms as determined by immunocytochemistry. Am J Pathol 1987;126:243–257.

    PubMed  CAS  Google Scholar 

  345. Hammar S, Gould VE. Neuroendocrine neoplasms. In: Azar HA, ed. Pathology of human neoplasms: an atlas of diagnostic electron microscopy and immunohistochemistry. New York: Raven Press, 1988: 333–404.

    Google Scholar 

  346. Barnes PJ, Baranivk JN, Belvisi MG. Neuropeptides in the respiratory tract. Am Rev Respir Dis 1991; 144(1):1187–1198;

    PubMed  CAS  Google Scholar 

  347. Barnes PJ, Baranivk JN, Belvisi MG. Neuropeptides in the respiratory tract. Am Rev Respir Dis 1991; 144(2):1391–1399.

    PubMed  CAS  Google Scholar 

  348. Haimoto H, Takahashi Y, Koshikawa T, Nagura H, Kato K. Immunohistochemical localization of γ-enolase in normal human tissues other than nervous and neuroendocrine tissues. Lab Invest 1985;52:257–263.

    PubMed  CAS  Google Scholar 

  349. Pahlman S, Esscher T, Nilsson K. Expression of γ-subunit of enolase, neuron-specific enolase in human non-neuroendocrine tumors and derived cell lines. Lab Invest 1986;54:554–560.

    PubMed  CAS  Google Scholar 

  350. Vinores SA, Bonnin JM, Rubinstein LJ, Marangos PJ. Immunohistochemical demonstration of neuron-specific enolase in neoplasms of the CNS and other tissues. Arch Pathol Lab Med 1984;120:186–192.

    Google Scholar 

  351. Bergh J, Escher T, Steinholtz L, Nilsson K, Pahlman S. Immunocytochemical demonstration of neuron-specific enolase (NSE) in human lung cancers. Am J Clin Pathol 1985;84:1–7.

    PubMed  CAS  Google Scholar 

  352. Said JW, Vimadalal S, Nash G, et al. Immunoreactive neuron-specific enolase, bombesin, and chromogranin as markers for neuroendocrine lung tumors. Hum Pathol 1985;16:236–240.

    PubMed  CAS  Google Scholar 

  353. Schmechel DE. γ-subunit of the glycolytic enzyme enolase: nonspecific or neuron specific? Lab Invest 1985; 52:239–242.

    PubMed  CAS  Google Scholar 

  354. O’Connor DT, Burton D, Deftos LJ. Immunoreactive human chromogranin A in diverse polypeptide hormone producing human tumors and normal endocrine tissues. J Clin Endocrinol Metab 1983;57:1084–1086.

    PubMed  Google Scholar 

  355. Lloyd RV, Wilson BS, Kovacs K, Ryan N. Immunohistochemical localization of chromogranin in human hypophyses and pituitary adenomas. Arch Pathol Lab Med 1985;109:515–517.

    PubMed  CAS  Google Scholar 

  356. McNutt MA, Bolen JW. Adenomatous tumor of the middle ear. Am J Clin Pathol 1985;84:541–547.

    PubMed  CAS  Google Scholar 

  357. Bussolati G, Gugliotta P. Sapino A, Eusebi V, Lloyd R. Chromogranin-reactive endocrine cells in argyrophilic carcinomas (“carcinoids”) from normal tissue of the breast. Am J Pathol 1985;120:186–192.

    PubMed  CAS  Google Scholar 

  358. O’Connor DT, Deftos LJ. Secretion of chromogranin A by peptide-producing endocrine neoplasms. N Engl J Med 1986;314:1145–1151.

    PubMed  Google Scholar 

  359. Lloyd RV, Sisson JC, Shapiro B, Verhofstad AAJ. Immunohistochemical localization of epinephrine, norepinephrine, catecholamine-synthesizing enzymes and chromogranin in neuroendocrine cells and tumors. Am J Pathol 1986;125:45–54.

    PubMed  CAS  Google Scholar 

  360. Banks P, Helle K. The release of protein from the stimulated adrenal medulla. Biochem J 1965;97:40C-41C.

    PubMed  CAS  Google Scholar 

  361. Angeletti RH. Chromogranins and neuroendocrine secretion. Lab Invest 1986;55:387–390.

    PubMed  CAS  Google Scholar 

  362. Wilson BS, Lloyd RV. Detection of chromogranin in neuroendocrine cells with a monoclonal antibody. Am J Pathol 1984;115:458–468.

    PubMed  CAS  Google Scholar 

  363. Lauweryns JM, vanRanst K, Lloyd RV, et al. Chromogranin in bronchopulmonary neuroendocrine cells: Immunohistochemical detection in human, monkey and pig respiratory mucosa. J Histochem Cytochem 1987;35:113–118.

    PubMed  CAS  Google Scholar 

  364. Mukai M, Torikata C, Iri H, et al. Expression of neurofilament triplet proteins in human neural tumor: An immunohistochemical study of paraganglioma, ganglioneuroma, ganglioneuroblastoma and neuroblastoma. Am J Pathol 1986;122:28–36.

    PubMed  CAS  Google Scholar 

  365. Shah IA, Schlageter M, Netto D. Immunoreactivity of neurofilament proteins in neuroendocrine neoplasms. Mod Pathol 1991;4:215–219.

    PubMed  CAS  Google Scholar 

  366. Leoncini P, DeMarco EB, Bugnoli M. Mencarelli C, Vindigni C, Cintorino M. Expression of phosphorylated and non-phosphorylated neurofilament subunits and cytokeratins in neuroendocrine lung tumors. Pathol Res Pract 1989;185:848–855.

    PubMed  CAS  Google Scholar 

  367. Jahn B, Schibler W, Ouimet C, et al. A 38,000 dalton membrane protein (p38) present in synaptic vesicles. Proc Natl Acad Sci USA 1985;82:4137–4141.

    PubMed  CAS  Google Scholar 

  368. Gould VE, Lee I, Wiedenmann B, Moll R, Chejfec G, Franke WW. Synaptophysin: A novel marker for neurons, certain neuroendocrine cells and their neoplasms. Hum Pathol 1986;17:979–983.

    PubMed  CAS  Google Scholar 

  369. Bunn P, Linnoila I, Minna J, Carney D, Gazdar AF. Small cell cancer, endocrine cells of the fetal bronchus, and other neuroendocrine cells express Leu7 antigenic determinant present on natural killer cells. Blood 1985;65:764–768.

    PubMed  Google Scholar 

  370. Tsutsumi Y. Leu7 immunoreactivity as a histochemical marker for paraffin-embedded neuroendocrine tumors. Acta Histochem Cytochem 1984; 17:15.

    Google Scholar 

  371. Tischler AS, Mobtaker H, Mann K, et al. Anti-lymphocyte monoclonal antibody HNK-1 (Leu7) recognizes a constituent of neuroendocrine matrix. Lab Invest 1986;54:64A.

    Google Scholar 

  372. Komminoth P, Roth J, Lackie PM, Bitter-Suermann D, Heitz PU. Polysialic acid of the neural cell adhesion molecule distinguishes small cell lung carcinoma from carcinoids. Am J Pathol 1991;139:297–304.

    PubMed  CAS  Google Scholar 

  373. Kibbelaar RE, Moolenaar CEC, Michalides RJAM, Bitter-Suermann D, Addis BJ, Mooi WJ. Expression of the embryonal neural cell adhesion molecular N-CAM in lung carcinoma. Diagnostic usefulness of monoclonal antibody 735 for the distinction between small cell lung cancer and non-small cell lung cancer. J Pathol 1989;159:23–28.

    PubMed  CAS  Google Scholar 

  374. Moolenaar CE, Muller EJ, Schol DJ, Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer, and neuroblastoma cell lines H69 and CHP-212. Cancer Res 1990;50:1102–1106.

    PubMed  CAS  Google Scholar 

  375. Kahn HJ, Garrido A, Huang S-N, Baumal R. Intermediate filaments and tumor diagnosis. Lab Invest 1983;49:509.

    Google Scholar 

  376. Lehto V-P, Stenman S, Miettinen M, Dahl D, Virtanen I. Expression of a neural type of intermediate filament as a distinguishing feature between oat cell carcinoma and other lung cancers. Am J Pathol 1983;110:113–118.

    PubMed  CAS  Google Scholar 

  377. VanMuijen GNP, Ruiter DJ, Leeuwen CV, Prins FA, Rietsema K, Warnaar SO. Cytokeratin and neurofilament in lung carcinomas. Am J Pathol 1984;116:363–369.

    CAS  Google Scholar 

  378. Lehto V-P, Miettinen M, Dahl D, Virtanen I. Bronchial carcinoid cells contain neural-type intermediate filaments. Cancer (Philadelphia) 1984;54:624–628.

    CAS  Google Scholar 

  379. Clark RK, Miettinen M, Leij L, Damjanov I. Terminally differentiated derivatives of pulmonary small cell carcinomas may contain neurofilaments. Lab Invest 1985;53:243–244.

    PubMed  CAS  Google Scholar 

  380. Broers J, Huysmans A, Moesker O, Vooijs P, Ramaekers F, Wagenaar S. Small cell lung cancer contains intermediate filaments of the cytokeratin type. Lab Invest 1985;52:113–114.

    PubMed  CAS  Google Scholar 

  381. Moll R, Franke WW, Schiller DL, et al. The catalogue of human cytokeratins. Patterns of expression in normal epithelia, tumors and cultured cells. Cell 1982;31:11–24.

    PubMed  CAS  Google Scholar 

  382. Cooper D, Schermer A, Sun T-T. Classification of human epithelia and their neoplasms using monoclonal antibodies to keratins: Strategies, applications and limitations. Lab Invest 1985;52:243–256.

    PubMed  CAS  Google Scholar 

  383. Gown AM, Gabbiani G. Intermediate-sized (10-nm) filaments in human tumors. In: DeLellis, RA, ed. Advances in immunohistochemistry. New York: Masson, 1984:89–109.

    Google Scholar 

  384. Miettinen M, Lehto V-P, Virtanen I. Antibodies to intermediate filament proteins in the diagnosis and classification of human tumors. Ultrastruct Pathol 1984;7:83–107.

    PubMed  CAS  Google Scholar 

  385. Moll R, Cowin P, Kapprell H-P, Franke WW. Desmosomal proteins: New markers for identification and classification of tumors. Lab Invest 1986;54:4–25.

    PubMed  CAS  Google Scholar 

  386. Funa K, Gazdar AF, Minna JD, Linnoila RI. Paucity of B2-microglobulin expression on small cell lung cancer, bronchial carcinoids, and certain other neuroendocrine tumors. Lab Invest 1986;55:186–192.

    PubMed  CAS  Google Scholar 

  387. Payne CM, Nagle RB, Borduin V. Methods in laboratory investigation: an ultrastructural cytochemical stain specific for neuroendocrine neoplasms. Lab Invest 1984;51:350–365.

    PubMed  CAS  Google Scholar 

  388. Nagle RB, Payne CM, Clark VA. Comparison of the usefulness of histochemistry and ultrastructural cytochemistry in the identification of neuroendocrine neoplasms. Am J Clin Pathol 1986;85:289–296.

    PubMed  CAS  Google Scholar 

  389. Gould VE, Benditt EP. Ultrastructural and functional relationships of some human endocrine tumors. Pathol Annu 1973;8:205–230.

    PubMed  CAS  Google Scholar 

  390. Gould VE. Neuroendocrinomas and neuroendocrine carcinomas: APUD-cell system neoplasms and their aberrant secretory activities. Pathol Annu 1977;12 (Part 2):33–62.

    PubMed  Google Scholar 

  391. Sunday ME, Choi N, Spindel ER, Chin WW, Mark EJ. Gastrin-releasing peptide gene expression in small cell and large cell undifferentiated carcinomas. Hum pathol 1991;22:1030–1039.

    PubMed  CAS  Google Scholar 

  392. Hamid Q, Corrin B, Sheppard MN, Polak JM. Localization of chromogranin mRNA in small cell carcinoma of the lung. J Pathol 1991;163:293–297.

    PubMed  CAS  Google Scholar 

  393. Frohlich F. Die ‘Helle Zelle’ der Bronchialschleimhaut und ihre Beziehungen zum Problem der Chemoreceptoren. Frankfurt Ztschr Z Pathol 1949;60:517–559.

    CAS  Google Scholar 

  394. Feyrter F. Zur Pathologie des argyrophilen Helle-Zell-Organes im Bronchialbaum des Menschen. Virchows Arch 1954;325:723–732.

    PubMed  CAS  Google Scholar 

  395. Bensch KG, Gordon GB, Miller LR. Studies on the bronchial counterpart of the Kultschitzky (argentaffin) cell and innervation of bronchial glands. J Ultrastruct Res 1965;12:668–686.

    PubMed  CAS  Google Scholar 

  396. Bensch KG, Gordon GB, Miller LR. Electron microscopic and biochemical studies on the bronchial carcinoid tumor. Cancer 1965;18:592–602.

    PubMed  CAS  Google Scholar 

  397. Gmelich JT, Bensch KG, Liebow AA. Cells of Kulchitzky type in bronchioles and their relation to the origin of peripheral carcinoid tumor. Lab Invest 1967;17:88–98.

    PubMed  CAS  Google Scholar 

  398. Lauweryns JM, Cokelaere M. Theunynck PK. Neuroepithelial bodies in the respiratory mucosa of various mammals: a light optical, histochemical, and ultrastructural investigation. Z Zellforsch Mikrosk Anat 1972; 135:569–592.

    PubMed  CAS  Google Scholar 

  399. Lauweryns JM, Goddeeris P. Neuroepithelial bodies in the human child and adult lung. Am Rev Respir Dis 1975;111:469–476.

    PubMed  CAS  Google Scholar 

  400. Johnson DE, Loch JE, Elde RP, Thompson TR. Pulmonary neuroendocrine cells in bronchopulmonary dysplasia and hyaline membrane disease. Pediatr Res 1982;16:446–454.

    PubMed  CAS  Google Scholar 

  401. Johnson DE, Wobken JD, Landrum BG. Changes in bombesin, calcitonin and serotonin immunoreactive pulmonary neuroendocrine cells in cystic fibrosis and after prolonged mechanical ventilation. Am Rev Respir Dis 1988;137:123–131.

    PubMed  CAS  Google Scholar 

  402. Stahlman MT, Gray ME. Ontogeny of neuroendocrine cells in human fetal lung. I. An electron microscopic study. Lab Invest 1984;51:449–463.

    PubMed  CAS  Google Scholar 

  403. Stahlman MT, Kasselberg AG, Orth DN, Gray ME. Ontogeny of neuroendocrine cells in human fetal lung. II. An immunohistochemical study. Lab Invest 1985;52:52–60.

    PubMed  CAS  Google Scholar 

  404. Spindel ER, Sunday ME, Hofler H, Wolfe HJ, Habener JF, Chin WW. Transient elevation of messenger RNA encoding gastrin releating peptide, a putative pulmonary growth factor in human fetal lung. J Clin Invest 1987;80:1172–1179.

    PubMed  CAS  Google Scholar 

  405. Sobol RE, O’Connor DT, Addison J, Suchocki K, Royston I, Deftos LJ. Elevated serum chromogranin A levels in small cell lung carcinoma. Ann Intern Med 1986;1095:698–700.

    Google Scholar 

  406. Gosney JR, Sissons MCJ, Allibone RO, Blakely AF. Pulmonary endocrine cells in chronic bronchitis and emphysema. J Pathol 1989;157:127–133.

    PubMed  CAS  Google Scholar 

  407. Aguayo SM, King TE, Jr., Waldron JA, Jr., Sherritt KM, Kane MA, Miller YE. Increased pulmonary neuroendocrine cells with bombesin-like immunoreactivity in adults with eosinophilic granuloma. J Clin Invest 1989;86:838–844.

    Google Scholar 

  408. Aguayo SM, Kane MA, King TE, Jr., Schwarz MI, Graver L, Miller YE. Increased levels of bombesin-like peptides in the lower respiratory tract of asymptomatic cigarette smokers. J Clin Invest 1989;84:1105–1113.

    PubMed  CAS  Google Scholar 

  409. Tabassian AR, Nylen ES, Linnoila RI, Snider RH, Cassidy MM, Becker KL. Stimulation of hamster pulmonary neuroendocrine cells and associated peptides by repeated exposure to cigarette smoke. Am Rev Respir Dis 1989;140:436–440.

    PubMed  CAS  Google Scholar 

  410. Aguayo SM, Miller YE, Waldron JA, Jr., et al. Brief report: Idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease. N Engl J Med 1992;327:1285–1288.

    PubMed  CAS  Google Scholar 

  411. Benfield JR. Neuroendocrine neoplasms of the lung. J Thorac Cardiovasc Surg 1990;100:628–629.

    PubMed  CAS  Google Scholar 

  412. Whitwell F. Tumorlets of the lung. J Pathol Bacteriol 1955;70:529–541.

    PubMed  CAS  Google Scholar 

  413. Churg A, Warnock ML. Pulmonary tumorlet: A form of peripheral carcinoid. Cancer (Philadelphia) 1976; 37:1469–1477.

    Google Scholar 

  414. Miller MA, Mark J, Kanarek D. Multiple peripheral pulmonary carcinoids and tumorlets of carcinoid type, with restrictive and obstructive lung disease. Am J Med 1978;65:373–378.

    PubMed  CAS  Google Scholar 

  415. Pelosi G, Zancanaro C, Sbubo L, Bresaola E, Martignoni G, Bontempini L. Development of innumerable neuroendocrine tumorlets in pulmonary lobe scarred by intralobular sequestration: Immunohistochemical and ultrastructural study of an unusual case. Arch Pathol Lab Med 1992;116:1167–1174.

    PubMed  CAS  Google Scholar 

  416. D’Aggti VD, Perzin KH. Carcinoid tumorlets of the lung with metastasis to a peribronchial lymph node: report of a case and review of the literature. Cancer (Philadelphia) 1985;55:2472–2476.

    Google Scholar 

  417. Mueller H. Zur Untersuchungsgeschichte der bronchialen Weiterungen. Inaug Diss Halle, 1882.

    Google Scholar 

  418. Kramer R. Adenoma of bronchus. Ann Otol Rhinol Laryngol 1930;39:689–695.

    Google Scholar 

  419. Hamperl H. Über gutartige Bronchialtumoren. Virchows Arch [Pathol Anat] 1937;300:1937:46–88.

    Google Scholar 

  420. Oberndorfer S. Karzinoide Tumoren des Diinndarms. Frankfurt Zeitschr Pathol 1907;1:426–432.

    Google Scholar 

  421. Briselli M, Mark GJ, Grillo HC. Tracheal carcinoids. Cancer (Philadelphia) 1978;42:2870–2879.

    CAS  Google Scholar 

  422. Bonikos DS, Bensch KG, Jamplis RW. Peripheral pulmonary carcinoid tumors. Cancer (Philadelphia) 1976;37:1977–1998.

    CAS  Google Scholar 

  423. Felton WL, Liebow AA, Lindskog GE. Peripheral and multiple bronchial adenomas. Cancer (Philadelphia) 1953;6:555–567.

    Google Scholar 

  424. Skinner C, Ewen SWB. Carcinoid lung: diffuse pulmonary infiltration by a multifocal bronchial carcinoid. Thorax 1976;31:212–219.

    PubMed  CAS  Google Scholar 

  425. Abdi EA, Goel R, Bishop S, Bain GO. Peripheral carcinoid tumours of the lung: A clinicopathological study. J Surg Oncol 1988;39:190–196.

    PubMed  CAS  Google Scholar 

  426. Carter D, Eggleston JC, Carcinoid tumors. In: Tumors of the lower respiratory tract. Atlas of tumor pathology, 2d Ser., Fasc. 17. Washington, DC: Armed Forces Institute of Pathology, 1980:162–188.

    Google Scholar 

  427. Mark EJ, Quay SC, Dickensin GR. Papillary carcinoid tumor of the lung. Cancer (Philadelphia) 1981;48:316–324.

    CAS  Google Scholar 

  428. Ranchod M, Levine GD. Spindle cell carcinoid tumors of the lung: A clinicopathologic study of 35 cases. Am J Surg Pathol 1980;4:315–331.

    PubMed  CAS  Google Scholar 

  429. Sklar JL, Churg A, Bensch KG. Oncocytic carcinoid tumor of the lung. Am J Surg Pathol 1980;4:287–292.

    PubMed  CAS  Google Scholar 

  430. Sajjad SM, Mackay B, Lukeman JM. Oncocytic carcinoid tumor of the lung. Ultrastruct Pathol 1980;l:17l–176.

    Google Scholar 

  431. Scharifker D, Marchevsky A. Oncocytic carcinoid of lung: an ultrastructural analysis. Cancer (Philadelphia) 1981;47:530–532.

    CAS  Google Scholar 

  432. Ghadially FN, Block HJ. Oncocytic carcinoid of the lung. J Submicrosc Cytol 1985;17:435–442.

    PubMed  CAS  Google Scholar 

  433. Santos-Briz, Terron J, Sastre R, Romero L, Valle A. Oncocytoma of the lung. Cancer 1977;40:1330–1336.

    PubMed  CAS  Google Scholar 

  434. Cebelin MS. Melanocytic bronchial carcinoid tumor. Cancer (Philadelphia) 1980;46:1843–1848.

    CAS  Google Scholar 

  435. Grazer R, Cohen SM, Jacobs JB, Lucas P. Melanin-containing peripheral carcinoid of the lung. Am J Surg Pathol 1982;6:73–78.

    PubMed  CAS  Google Scholar 

  436. Carlson JA, Dickersin GR. Melanocytic paraganglioid carcinoid tumor: A case report and review of the literature. Ultra Pathol 1993;17:353–372.

    Google Scholar 

  437. Barbareschi M, Frigo B, Mosca L, et al. Bronchial carcinoids with S100 positive sustenatacular cells. Pathol Res Pract 1990;186:212–217.

    PubMed  CAS  Google Scholar 

  438. Capella C, Gabrielli M, Polak JM, Buffa R, Solcia E. Ultrastructural and histological study of 11 bronchial carcinoids. Virchows Arch Pathol Anat [A] 1979;381:313–329.

    CAS  Google Scholar 

  439. Barbareschi M, Frigo B, Cristina S, Valentini L, Leonardi E, Mosca L. Bronchial carcinoid with paranuclear fibrillary inclusions related to cytokeratins and vimentin. Virchows Arch [A] Pathol Anat 1989;415:31–36.

    CAS  Google Scholar 

  440. Arrigoni MG, Woolner LB, Bernatz PE. Atypical carcinoid tumors of the lung. J Thorac Cardiovasc Surg 1972;64:413–421.

    PubMed  CAS  Google Scholar 

  441. Leschke H. Über nur regionär bösartige und über krebsig entartete Bronchusadenome bzw. Carcinoide. Virchows Arch [Path Anat] 1956;328:635–657.

    CAS  Google Scholar 

  442. Warren WH, Memoli VA, Gould VE. Immunohistochemical and ultrastructural analysis of bronchopulmonary neuroendocrine neoplasms. II. Well-differentiated neuroendocrine carcinomas. Ultrastruct Pathol 1984;7:185–199.

    PubMed  Google Scholar 

  443. Mark EJ, Ramirez JF. Peripheral small-cell carcinoma of the lung resembling carcinoid tumor: A clinical and pathologic study of 14 cases. Arch Pathol Lab Med 1985;109:263–269.

    PubMed  CAS  Google Scholar 

  444. Paladugu RR, Benfield JR, Pak HY, Ross RK, Teplitz RL. Bronchopulmonary kulchitzky cell carcinomas. Cancer (Philadelphia) 1985;55:1303–1311.

    CAS  Google Scholar 

  445. Tsutsumi Y, Yazaki K, Yoshioka K. Atypical carcinoid tumor of the lung, associated with giant cell transformation in bone metastases. Jap Soc Pathol 1990; 40:609–615.

    CAS  Google Scholar 

  446. Hammar S, Bockus D, Remington F, Cooper L. The unusual spectrum of neuroendocrine lung neoplasms. Ultra Pathol 1989;13(5,6):515–560.

    CAS  Google Scholar 

  447. Gould VE, Chejfec G. Ultrastructural and biochemical analysis of pulmonary “undifferentiated” carcinomas. Hum Pathol 1978;9:377–384.

    PubMed  CAS  Google Scholar 

  448. McDowell EM, Wilson TS, Trump BF. Atypical endocrine tumors of the lung. Arch Pathol Lab Med 1981;105:20–28.

    PubMed  CAS  Google Scholar 

  449. Hammond ME, Sause WT. Large cell neuroendocrine tumors of the lung: Clinical significance and histopathologic definition. Cancer (Philadelphia) 1985;56:1624–1629.

    CAS  Google Scholar 

  450. Neal MH, Kosinki R, Cohen P, Orenstein JM. Atypical endocrine tumors of the lung: a histologic, ultrastructural and clinical study of 19 cases. Hum Pathol 1986;17:1264–1277.

    PubMed  CAS  Google Scholar 

  451. Barbareschi M, Mariscotti C, Barberis M, Frigo B, Mosca L. Large cell neuroendocrine carcinoma of the lung. Tumori 1989;75:583–588.

    PubMed  CAS  Google Scholar 

  452. Travis WD, Linnoila I, Tsokos MG, et al. Neuroendocrine tumors of the lung with proposed criteria for large cell neuroendocrine carcinoma: An ultrastructural, immunohistochemical and flow cytometric study of 35 cases. Am J Surg Pathol 1991;15:529–533.

    PubMed  CAS  Google Scholar 

  453. Wick MR, Berg LC, Hertz MI. Large cell carcinoma of the lung with neuroendocrine differentiation; a comparison with large cell “undifferentiated” pulmonary tumors. Am J Clin Pathol 1992;987:796–805.

    Google Scholar 

  454. Mooi WJ, Dewar A, Springall D, Polak JM, Addis BJ. Non-small cell lung carcinomas with neuroendocrine features: A light microscopic, immunohistochemical and ultrastructural study of 11 cases. Histopathology 1988;13:329–337.

    PubMed  CAS  Google Scholar 

  455. Vosika GJ. Large cell bronchogenic carcinoma: Prolonged disease-free survival following chemotherapy. JAMA 1979;241:594–595.

    PubMed  CAS  Google Scholar 

  456. Gibbs FA. Lymphoma versus carcinoma. JAMA 1979;242:514.

    PubMed  Google Scholar 

  457. Vosika GJ. Large cell-small cell bronchogenic carcinoma. JAMA 1979;242:1259–1260.

    Google Scholar 

  458. Bernard WG. The nature of the “oat-celled sarcoma” of the mediastinum. J Pathol Bacteriol 1926;29:241–244.

    Google Scholar 

  459. Gibbon JH Jr, Nealon TF Jr. Neoplasms of the lungs and trachea. In: Gibbon JH Jr, ed. Surgery of the chest. Philadelphia: Saunders, 1962:484.

    Google Scholar 

  460. Azzopardi JG. Oat-cell carcinoma of the bronchus. J Pathol Bacteriol 1959;78:513–519.

    PubMed  CAS  Google Scholar 

  461. Yesner R. Small cell tumors of the lung. Am J Surg Pathol 1983;7:775–785.

    PubMed  CAS  Google Scholar 

  462. Carter D. Small-cell carcinoma of the lung. Am J Surg Pathol 1983;7:787–795.

    PubMed  CAS  Google Scholar 

  463. Yesner R. Classification of lung-cancer histology. N Engl J Med 1985;312:652–653.

    PubMed  CAS  Google Scholar 

  464. Stuart-Harris R, Boyer M, Greenberg M, Stevens S, Yung T. The histopathological classification of small cell lung cancer: Application of the IASLC classification in 124 cases. Lung Cancer 1992;8:63–70.

    Google Scholar 

  465. Gazdar AF, Carney DN, Baylin SB, et al. Small cell carcinoma of the lung. Altered morphological, biological and biochemical characteristics in long term cultures and heterotransplanted tumors. Proc Am Assoc Cancer Res 1980;21:51.

    Google Scholar 

  466. Fushimi H, Kihui M, Morino H, et al. Detection of large cell component in small cell lung carcinoma by combined cytologic and histologic examinations and its clinical implications. Cancer (Philadelphia) 1992;70:599–605.

    CAS  Google Scholar 

  467. Visscher DW, Zarbo RJ, Trojanowski JQ, Sakr W, Crissman JD. Neuroendocrine differentiation in poorly-differentiated lung carcinomas: a light microscopic and immunohistologic study. Mod Pathol 1990;3:508–512.

    PubMed  CAS  Google Scholar 

  468. Linnoila RI, Mulshine JL, Steinberg SM, et al. Neuroendocrine differentiation in endocrine and nonendocrine lung carcinomas. Am J Clin Pathol 1988;90:641–652.

    PubMed  CAS  Google Scholar 

  469. Chute CG, Greenberg ER, Baron J, Korson R, Baker J, Yates J. Presenting conditions of 1539 population-based lung cancer patients by cell type and stage in New Hampshire and Vermont. Cancer (Philadelphia) 1985;56:2107–2111.

    CAS  Google Scholar 

  470. Andersen HA, Bernatz PE. Extrathoracic manifestations of bronchogenic carcinoma. Med Clin N Am 1964;48:921–931.

    PubMed  CAS  Google Scholar 

  471. Mountain CF, Lukeman JM, Hammar S, et al. Lung cancer classification: The relationship of disease extent and cell type to survival in a trial population. J Surg Oncol 1987;35:147–156.

    PubMed  CAS  Google Scholar 

  472. Okike N, Bernatz PE, Woolner LB. Carcinoid tumors of the lung. Ann Thorac Surg 1976;22:270–275.

    PubMed  CAS  Google Scholar 

  473. Brandt B, Heintz SE, Rose EF, Ehrenhaft JL. Bronchial carcinoid tumors. Ann Thorac Surg 1984;38:63–65.

    PubMed  Google Scholar 

  474. McCaughan BC, Martini N, Bains MS. Bronchial carcinoids: Review of 124 cases. J Thorac Cardiovasc Surg 1985;89:8–17.

    PubMed  CAS  Google Scholar 

  475. Thunnissen FBJM, van Eijk J, Baak JPA, Schipper NW, Uyterlinde AM, Breederveld RS, Meijer S. Bronchopulmonary carcinoids and regional node metastases: a quantitative pathologic investigation. Am J Pathol 1988;132:119–122.

    PubMed  CAS  Google Scholar 

  476. Warren WH, Gould VE. Long-term follow-up of classical bronchial carcinoid tumors. Scan J Thor Cardiovasc Surg 1990;24:125–130.

    CAS  Google Scholar 

  477. El-Naggar A, Ballance W, Abdu Karim FW, Ordonez NG, McLemore D, Giacco GG, Batsakis JG. Typical and atypical bronchopulmonary carcinoids: A clinicopathologic and flow cytometric study. Am J Clin Pathol 1991;95:828–834.

    PubMed  Google Scholar 

  478. Yousem SA, Taylor SR. Typical and atypical carcinoid tumors of lung: A clinicopathologic and DNA analysis of 20 tumors. Mod Pathol 1990;3:502–507.

    PubMed  Google Scholar 

  479. Bernstein C, McGoey J, Lertzman M. Recurrent bronchial carcinoid tumor. Chest 1989;95:693–694.

    PubMed  CAS  Google Scholar 

  480. Greengard O, Head JF, Goldberg SL, Kirschner PA. Pulmonary carcinoid tumors: Enzymic discriminants, growth rate and early age of inception. Cancer Res 1986;46:2600–2605.

    PubMed  CAS  Google Scholar 

  481. Yousem SA. Pulmonary carcinoid tumors and well differentiated neuroendocrine carcinomas: Is there room for atypical carcinoid? Am J Cln Pathol 1991;95:828–834.

    Google Scholar 

  482. Warren WH, Memoli VA, Jordan AG, Gould VE., Reevaluation of pulmonary neoplasms as small cell neuroendocrine carcinomas. Cancer 1990;65:1003–1010.

    PubMed  CAS  Google Scholar 

  483. Larsimont D, Kiss R, deLaunoit Y, Melamed MR. Characterization of the morphonuclear features and DNA ploidy of typical and atypical carcinoids and small cell cell carcinomas of the lung. Am J Clin Pathol 1990;94:378–373.

    PubMed  CAS  Google Scholar 

  484. Lequaglie C, Patriarca C, Cataldo I, Muscolino G, Preda F, Ravasi G. Prognosis of resected well-differentiated neuroendocrine carcinoma of the lung. Chest 1991;100:1053–1056.

    PubMed  CAS  Google Scholar 

  485. Memoli VA. Well-differentiated neuroendocrine carcinoma: A designation comes of age. Chest 1991; 100:892.

    PubMed  CAS  Google Scholar 

  486. Jackson-York GL, Davis GH, Warren WH, Gould VE, Memoli VA. Flow cytometric DNA content analysis in neuroendocrine carcinoma of the lung: Correlation with survival and histologic subtype. Cancer (Philadelphia) 1991;68:374–379.

    Google Scholar 

  487. Quoix E, Fraser R, Wolkove N, Finkelstein H, Kreis-man H. Small cell lung cancer presenting as a solitary pulmonary nodule. Cancer (Philadelphia) 1990;66:577–582.

    CAS  Google Scholar 

  488. Kreisman H, Wolkove N, Quoix E. Small cell lung cancer presenting as a solitary pulmonary nodule. Chest 1992;101:225–229.

    PubMed  CAS  Google Scholar 

  489. Shepherd FA, Ginsberg R, Evans WK, Haddad R, Feld R, DeBoer G. “Very limited” small cell lung cancer: Results of nonsurgical treatment. Proc Am Soc Clin Oncol 1984;3:223–228.

    Google Scholar 

  490. Gephardt GN, Grady KJ, Ahmad M, Tubbs RR, Mehta ACl, Shepard KV. Peripheral small cell undifferentiated carcinoma of the lung: Clinicopathologic features of 17 cases. Cancer (Philadelphia) 1988;61:1002–1008.

    CAS  Google Scholar 

  491. Fraire AE, Johnson EH, Yesner R, Zhang XB, Spjut HJ, Greenberg SD. Prognostic significance of histopathologic subtype and stage in small cell lung cancer. Hum Pathol 1992;23:520–528.

    PubMed  CAS  Google Scholar 

  492. Bepler G, Neumann K, Holle R, Havemann K, Kalbfleisch H. Clinical relevance of histologic subtyping in small cell lung cancer. Cancer (Philadelphia) 1989;64:74–79.

    CAS  Google Scholar 

  493. Crown JPA, Chahinian AP, Jaffrey IS, Glidewell OJ, Kaneko M, Holland JR. Predictors of 5-year survival and curability in small cell lung cancer. Cancer (Philadelphia) 1990;66:382–386.

    CAS  Google Scholar 

  494. Albain KS, Crowley JJ, Livingston RB. Long-term survival and toxicity in small cell lung cancer: Expanded Southwest Oncology Group experience. Chest 1991;99:1425–1432.

    PubMed  Google Scholar 

  495. Oud PS, Pahlplatz MM, Beck LM, Wiersma-Van Tilburg A, Wagenaar SJ, Vooijs GP. Cancer (Philadelphia) 1989;64:1304–1309.

    CAS  Google Scholar 

  496. Funa K, Steinholtz L, Nov E, Bergh J. Increased expression of N-myc in human small cell lung cancer biopsies predicts lack of response to chemotherapy. Am J Clin Pathol 1987;88:216–220.

    PubMed  CAS  Google Scholar 

  497. Copple B, Wright SE, Moatamed F. Electron microscopy in small cell lung carcinomas: Clinical correlation. J Clin Oncol 1984;2:910–916.

    PubMed  CAS  Google Scholar 

  498. Vollmer RT, Shelburne JD, Iglehart JD. Intercellular junctions and tumor stage in small cell carcinoma of the lung. Hum Pathol 1986;18:22–27.

    Google Scholar 

  499. Elson CE, Roggli VL, Vollmer RT, Greenberg SD, Fraire AE, Spjut HJ, Yesner R. Prognostic indicators for survival in stage I carcinoma of the lung: A histologic study of 47 surgically resected cases. Mod Pathol 1988;1:288–291.

    PubMed  CAS  Google Scholar 

  500. Shahab I, Fraire AE, Greenberg SD, Johnson EH, Langston C, Roggli VL. Morphometric quantitation of tumor necrosis in stage I non-small cell carcinoma of lung: Prognostic implications. Mod Pathol 1992;5:521–524.

    PubMed  CAS  Google Scholar 

  501. Cagle PT, Langston C, Fraire AE, Roggli VL, Greenberg SD. Absence of correlation between nuclear morphometry and survival in stage I non-small cell lung carcinoma. Cancer (Philadelphia) 1992;69:2454–2457.

    CAS  Google Scholar 

  502. Gallagher B, Urbanski SJ. The significance of pleural elastica invasion by lung carcinomas. Hum Pathol 1990;21:512–517.

    PubMed  CAS  Google Scholar 

  503. Ratto GB, Frola C, Sacco G, Motta G. The prognostic significance of minor pleural effusions in patients with potentially operable bronchogenic carcinoma. Lung Cancer 1987;3:117–122.

    Google Scholar 

  504. Yoshimoto T, Higashino K, Hada T, et al. A primary lung carcinoma producing alpha-fetoprotein, carcino-embryonic antigen and human chorionic-gonadotropin. Cancer (Philadelphia) 1987;60:2744–2750.

    CAS  Google Scholar 

  505. Kuida CA, Braunstein GD, Shintaku P, Said JW. Human chorionic-gonadotropin expression in lung, breast, and renal carcinomas. Arch Pathol Lab Med 1988;112:282–285.

    PubMed  CAS  Google Scholar 

  506. Beattie CW, Hansen NW, Thomas PA. Steroid receptors in human lung cancer. Cancer Res 1985;45:4206–4214.

    PubMed  CAS  Google Scholar 

  507. Baltifora H, Sorensen HR, Mehta P, et al. Tumorassociated antigen 43-9F is of prognostic value in squamous cell carcinoma of the lung. Cancer 1992;70:1867–1872.

    Google Scholar 

  508. Poulakis N. Sarandakou S, Rizos D, Phocas I, Kontozoglou T, Polyzogopoulos D. Soluble interleukin-2-receptors and other markers in primary lung cancer. Cancer (Philadelphia) 1991;68:1045–1049.

    CAS  Google Scholar 

  509. Miyake M, Taki T, Hitomi S, Hakomori S. Correlation of expression of H/Le-y/Le-b antigens with survival in patients with carcinoma of the lung. N Engl J Med 1992;327:14–18.

    PubMed  CAS  Google Scholar 

  510. Buccheri G, Ferrigno D. Prognostic value of the tissue polypetide antigen in lung cancer. Chest 1992;101:1287–1292.

    PubMed  CAS  Google Scholar 

  511. Cline MJ, Battifora H. Abnormalities of protooncogenes in non-small cell lung cancer: Correlations with tumor type and clinical characteristics. Cancer (Philadelphia) 1987;60:2669–2674.

    CAS  Google Scholar 

  512. Harada M, Dosaka-Akita H, Miyamoto H, Kuzumaki N, Kawakami Y. Prognostic significance of the expression of ras oncogene product in non-small cell lung cancer. Cancer 1992;69:72–77.

    PubMed  CAS  Google Scholar 

  513. Caamano J, Ruggeri B, Momiki S, Sickler A, Zhang SY, Klein-Szanto AJP. Detection of p53 in primary lung tumors and non-small cell lung carcinoma cell lines. Am J Pathol 1991;139:839–845.

    PubMed  CAS  Google Scholar 

  514. Porter PL, Gown AM, Kramp SG, Coltrea MD. Wide-spread p53 overexpression in human malignant tumors: An immunohistochemical study using methacarn-fixed, embedded tissue. Am J Pathol 1992;140:145–152.

    PubMed  CAS  Google Scholar 

  515. Slebos RJC, Kibbelaar RE, Dalesio O, et al. K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. N Engl J Med 1990;323:561–565.

    PubMed  CAS  Google Scholar 

  516. ten Velde GPM, Havenith MG. Volovics A, Bosman FT. Prognostic significance of basement membrane deposition in operable squamous cell carcinomas of the lung. Cancer (Philadelphia) 1991;67:3001–3005.

    Google Scholar 

  517. Nagamoto N, Saito Y, Ohta S. Relationship of lymph node metastasis to primary tumor size and microscopic appearance of roentgenographically occult lung cancer. Am J Surg Pathol 1989;13:1009–1013.

    PubMed  CAS  Google Scholar 

  518. Atsushi T, Kodama T, Shimosato Y, Watanabe S, Suemasu K. Histopathologic prognostic factors in adenocarcinomas of the peripheral lung less than 2 cm in diameter. Cancer (Philadelphia) 1988;61:2083–2088.

    Google Scholar 

  519. Ohori NP, Yousem SA, Griffin J, et al. Comparison of extracellular matrix antigens in subtypes of bronchioloalveolar carcinoma and conventional pulmonary adenocarcinoma: An immunohistochemical study. Am J Surg Pathol 1992;16:675–686.

    PubMed  CAS  Google Scholar 

  520. Delmomte VC, Alberti O, Saldiva PHN. Large cell carcinoma of the lung—ultrastructural and immunohistochemical features. Chest 1986;90:524–527.

    Google Scholar 

  521. Albain KS, True LD, Golomb HM, Hoffman PC, Little AG. Large cell carcinoma of the lung: Ultrastructural differentiation and clinicopathologic correlations. Cancer (Philadelphia) 1985;56:1618–1623.

    CAS  Google Scholar 

  522. Coon JS, Landay AL, Weinstein RS. Biology of disease: Advances in flow cytometry for diagnostic pathology. Lab Invest 1987;57:453–479.

    PubMed  CAS  Google Scholar 

  523. Wersto RP, Liblit RL, Ross LG. Flow cyctometric DNA analysis of human solid tumors: A review of the interpretation of DNA histograms. Hum Pathol 1991; 22:1085–1098.

    PubMed  Google Scholar 

  524. Frierson HF, Jr. The need for improvement in flow cytometric analysis of ploidy and S-phase fraction. Am J Clin Pathol 1991;96:439–441.

    Google Scholar 

  525. Zimmerman PV, Bint MH, Hawson GAT, Parsons PG. Ploidy as a prognostic determinant in surgically treated lung cancer. Lancet 1987;ii:530–533.

    Google Scholar 

  526. Tirindelli-Danesi D, Teodori L, Mauro F, et al. Prognostic significance of flow cytometry in lung cancer: A 5-year study. Cancer (Philadelphia) 1987;60:844–851.

    CAS  Google Scholar 

  527. Asamura H, Nakajima T, Mukai K, Noguchi M, Shimosato Y. DNA cytofluorometric and nuclear morphometric analyses of lung adenocarcinoma. Cancer (Philadephia) 1989;64:1657–1664.

    CAS  Google Scholar 

  528. Salvati F, Teodori L, Gagliiardi L, Signora M, Aquilini M, Storniello G. DNA flow cytometric studies of 66 human lung tumors analyzed before treatment: Prognostic implications. Chest 1989;96:1092–1098.

    PubMed  CAS  Google Scholar 

  529. Carey FA, Lamb B, Bird CC. Intramural heterogeneity of DNA content in lung cancer. Cancer (Philadelphia) 1991;64:2266–2269.

    Google Scholar 

  530. Schmidt RA, Rusch VW, Piantadosi S. A flow cytometric study of non-small cell lung cancer classified as T1N0. Cancer (Philadelphia) 1992;69:78–85.

    CAS  Google Scholar 

  531. Filderman AE, Silvestri GA, Gatsonis C, Lithringer DJ, Honig J, Flynn SD. Prognostic significance of tumor proliferative fraction and DNA content in stage I non-small cell lung cancer. Am Rev Respir Dis 1992;146:707–710.

    PubMed  CAS  Google Scholar 

  532. Ogawa J, Tsurmi T, Inove H, Shohtsu A. Relationship between tumor DNA ploidy and regional lymph node changes in lung cancer. Cancer (Philadelphia) 1992;69:1688–1695.

    CAS  Google Scholar 

  533. Ogura S, Abe S, Sukoh N, Kunikane H, Nakajima I, Inoue K, Kawakami Y. Correlation between nucleolar organizer regions visualized by silver staining and the growth rate in lung adenocarcinoma. Cancer (Philadelphia) 1992;70:63–68.

    CAS  Google Scholar 

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Hammar, S.P. (1995). Common Neoplasms. In: Pulmonary Pathology — Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2496-9_1

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