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Genital Herpes: Contemporary Management

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Cesarean Section

Part of the book series: Clinical Perspectives in Obstetrics and Gynecology ((CPOG))

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Abstract

To discuss the consequences of genital herpes during pregnancy, particularly as it relates to the route of delivery, it is necessary to review the classification of this infection.

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References

  1. Mertz GJ, Benedetti J, Ashley R, Selke S, Corey L. Risk factors for the sexual transmission of genital herpes. Ann Intern Med 1992;116:197–202.

    PubMed  CAS  Google Scholar 

  2. Bryson Y, Dillon M, Bernstein DI, Randolf J, Zakowski R, Garratty E. Risk of acquisition of genital herpes simplex virus type 2 in sex partners of persons with genital herpes: a prospective couple study. J Infect Dis 1993; 167:942–946.

    Article  PubMed  CAS  Google Scholar 

  3. Corey L, Holmes KK. Genital herpes simplex virus infections: current concepts in diagnosis, therapy and prevention. Ann Intern Med 1983;98:973–983.

    PubMed  CAS  Google Scholar 

  4. Mertz GJ, Schmidt O, Jourden JL, et al. Frequency of acquisition of first-episode genital infection with herpes simplex virus from symptomatic and asymptomatic source contacts. Sex Transm Dis 1985;12:33–39.

    Article  PubMed  CAS  Google Scholar 

  5. Boucher FD, Yasukawa LL, Bronzan RN, Hensleigh PA, Arvin AM, Prober CG. A prospective evaluation of primary genital herpes simplex virus type 2 infections acquired during pregnancy. Pediatr Infect Dis J 1990; 9:499–504.

    Article  PubMed  CAS  Google Scholar 

  6. Brown ZA, Vontver LA, Benedetti J, et al. Genital herpes in pregnancy: risk factors associated with recurrences and asymptomatic viral shedding. Am J Obstet Gynecol 1985;153:24–30.

    PubMed  CAS  Google Scholar 

  7. Koutsky LA, Stevens CE, Holmes KK, et al. Underdiagnosis of genital herpes by current clinical and viral-isolation procedures. N Engl J Med 1992;326:1533–1539.

    Article  PubMed  CAS  Google Scholar 

  8. Langenberg A, Benedetti J, Jenkins J, Ashley R, Winter C, Corey L. Development of clinically recognizable genital lesions among women previously identified as having “asymptomatic” herpes simplex virus type 2 infection. Ann Intern Med 1989;110:882-887.

    PubMed  CAS  Google Scholar 

  9. Hensleigh P, Andrews W, Brown Z, et al. Medical history and clinical presentation does not identify primary genital herpes infections in pregnant women. Presented at the 15th Annual Meeting, Society of Perinatal Obstetricians. January 23–28, 1995. Atlanta Hilton, Atlanta, Georgia.

    Google Scholar 

  10. Brown ZA, Benedetti J, Watts DH, et al. A comparison between detailed and simple histories in the diagnosis of genital herpes complicating pregnancy. Am J Obstet Gynecol 1994 (in press).

    Google Scholar 

  11. Ashley RA, Militonia J, Lee F, Nahmias A, Corey L. Comparison of Western blot (immunoblot) and glycoprotein G-specific immunodot enzyme assay for detecting anti-bodies to herpes simplex virus types 1 and 2 in human sera. J Clin Microbiol 1988;26: 662–667.

    PubMed  CAS  Google Scholar 

  12. Brown ZA, Benedetti J, Ashley R, Burchett S, et al. Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. N Engl J Med 1991;324:1247–1252.

    Article  PubMed  CAS  Google Scholar 

  13. Cone RW, Hobson AC, Brown ZA, et al. Frequent detection of genital herpes simplex virus DNA by polymerase chain reaction among pregnant women. JAMA 1994;272: 797–796.

    Article  Google Scholar 

  14. Sullivan-Bolyai J, Hull HF, Wilson C, Corey L. Neonatal herpes simplex virus infection in King County, Washington: increasing incidence and epidemiologic correlates. JAMA 1983;250:3059–3062.

    Article  PubMed  CAS  Google Scholar 

  15. Prober CG, Hensleigh PA, Boucher FD, Yasukawa LL, Au DS, Arvin AM. Use of routine viral cultures at delivery to identify neonates exposed to herpes simplex virus. N Engl J Med 1988;318:887–891.

    Article  PubMed  CAS  Google Scholar 

  16. Whitley RJ, Corey L, Arvin A, et al. Changing presentation of herpes simplex virus infection in neonates. J Infect Dis 1988;158:109–116.

    Article  PubMed  CAS  Google Scholar 

  17. Arvin AM, Yeager AS, Bruhn FW, Grossman M. Neonatal herpes simplex infection in the absence of mucocutaneous lesions. J Pediatr 1982;100:715–721.

    Article  PubMed  CAS  Google Scholar 

  18. Genital herpes infection—United States, 1966–1984. Morbid Mortal Wkly Rep 1986; 35:402–403.

    Google Scholar 

  19. Quinn TC, Cates W. Epidemiology of sexually transmitted diseases in the 1990s. In: Quinn TC, ed. Sexually transmitted diseases. Raven, New York, 1992:1–37.

    Google Scholar 

  20. Nahmias AJ, Lee FK, Beckman-Nahmias S. Sero-epidemiological and -sociological patterns of herpes simplex virus infection in the world. Scand J Infect Dis [suppl] 1990;69: 19–36.

    CAS  Google Scholar 

  21. Stone KM, Brooks CA, Guinan ME, Alexander ER. National surveillance for neonatal herpes simplex virus infections. Sex Transm Dis 1989;16:152–156.

    Article  PubMed  CAS  Google Scholar 

  22. Wolf M. Unpublished thesis. Obstetrical course and complications of women with symptomatic genital herpes: a population-based analysis, 1990.

    Google Scholar 

  23. Garland SM. Neonatal herpes simplex: Royal Women’s Hospital 10 year experience with management guidelines for herpes in pregnancy. Aust NZ J Obstet Gynecol 1992;32: 331–334.

    Article  CAS  Google Scholar 

  24. Chuang T. Neonatal herpes incidence, prevention and consequences. Am J Prev Med 1988;4:47–53.

    PubMed  CAS  Google Scholar 

  25. Whitley R, Arvin A, Prober C, et al. Predictors of morbidity and mortality in neonates with herpes simplex virus infections. N Engl J Med 1991;324:450–454.

    Article  PubMed  CAS  Google Scholar 

  26. Randolph AG, Washington AE, Prober CG. Cesarean delivery for women presenting with genital herpes lesions. JAMA 1993;270: 77–82.

    Article  PubMed  CAS  Google Scholar 

  27. Arvin AM, Hensleigh PA, Prober CG, et al. Failure of antepartum maternal cultures to predict the infant’s risk of exposure to herpes simplex virus at delivery. N Engl J Med 1991;324:1247–1252.

    Article  Google Scholar 

  28. Brown ZA, Vontver LA, Benedetti J, et al. Effects on infants of a first episode of genital herpes during pregnancy. N Engl J Med 1987;317:1246–1251.

    Article  PubMed  CAS  Google Scholar 

  29. Brown Z, Selke S, Zeh J, et al. HSV serocon-version during pregnancy and its impact on pregnancy outcome and infant development. In: Program and abstracts of the 32nd Inter-science Conference on Antimicrobial Agents and Chemotherapy, October 11–14, 1992, Anaheim, California.

    Google Scholar 

  30. Brown ZA, Annholm A, Ashley R, et al. HSV serological discordancy among sexual partners and rates of seroconversion during pregnancy. In: Program and abstracts of the Infectious Disease Society for Obstetrics and Gynecology, August 1993, Stowe, Vermont.

    Google Scholar 

  31. Prober CG, Corey L, Brown ZA, et al. The management of pregnancies complicated by genital infections with herpes simplex virus. Clin Infect Dis 1992;15:1031–1038.

    Article  PubMed  CAS  Google Scholar 

  32. Bujko M, Sulovic V, Sbutega-Milosevic G, Zwanovic V. Mode of delivery and level of passive immunity against herpes simplex virus. Clin Exp Obstet Gynecol 1989;16: 6–8.

    PubMed  CAS  Google Scholar 

  33. Nahmias AJ, Keyserling HH, Kerrick GM. Herpes simplex. In: Remington JS, Klein JO, eds. Infectious diseases of the fetus and newborn infant, 2nd Ed. Philadelphia: WB Saunders, 1983:636–678.

    Google Scholar 

  34. Gnann JW, Barton NH, Whitley RJ. Acyclovir: mechanism of action, pharmaco-kinetics, safety and clinical applications. Pharmacotherapy 1983;3:275–283.

    PubMed  CAS  Google Scholar 

  35. Kingsley S. Fetal and neonatal exposure to acyclovir. Paris, 1986: unpublished data.

    Google Scholar 

  36. Andrews EB, Yankaskas BC, Cordero JF, Schoeffler K, Hampp S, and the Acyclovir in Pregnancy Registry Advisory Committee. Acyclovir in pregnancy registry: six years experience. Obstet Gynecol 1992;79:7–13.

    PubMed  CAS  Google Scholar 

  37. Frenkel LM, Brown ZA, Bryson YJ, et al. Pharmacokinetics of acyclovir in the term human pregnancy and neonate. Am J Obstet Gynecol 1991;164:569–576.

    PubMed  CAS  Google Scholar 

  38. Lau RJ, Emery MG, Galinsky RE. Unexpected accumulation of acyclovir in breast milk. Obstet Gynecol 1987;69:468–471.

    PubMed  CAS  Google Scholar 

  39. Kaplowitz LG, Baker D, Gelb L, et al. Prolonged continuous acyclovir treatment of normal adults with frequently recurring genital herpes simplex virus infection. JAMA 1991;265:747–751.

    Article  PubMed  CAS  Google Scholar 

  40. Strauss SE, Seidlin M, Takiff HE, et al. Effect of oral acyclovir treatment on symptomatic and asymptomatic virus shedding in recurrent genital herpes. Sex Transm Dis 1989; 16:107–113.

    Article  Google Scholar 

  41. Stray-Pedersen B. Acyclovir in late pregnancy to prevent neonatal herpes simplex. Lancet 1990;336:756.

    Article  PubMed  CAS  Google Scholar 

  42. Scott L, Jackson G, Sanchez P, Castaneda Y, Hall M, Wendel G. Prevention of cesarean section for recurrent genital herpes simplex virus (HSV) using acyclovir suppressive therapy. Presented at the Society of Gynecologic Investigation, Abstract #S223, 1993, Orlando, Florida.

    Google Scholar 

  43. Haddad J, Langer B, Astruc D, Messer J, Lokiec F. Oral acyclovir and recurrent genital herpes in late pregnancy. Obstet Gynecol 1993;82:102–104.

    PubMed  CAS  Google Scholar 

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Authors
  1. Zane A. Brown
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Editor information

Editors and Affiliations

  1. Kaiser Permanente, Southern California Permanente Medical Group, 92505, Riverside, CA, USA

    Bruce L. Flamm M.D. (Research Chairman) (Research Chairman)

  2. Department of Obstetrics and Gynecology, University of California-Irvine Medical Center, 92668, Orange, CA, USA

    Edward J. Quilligan M.D. (Professor Emeritus) (Professor Emeritus)

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© 1995 Springer-Verlag New York, Inc.

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Brown, Z.A. (1995). Genital Herpes: Contemporary Management. In: Flamm, B.L., Quilligan, E.J. (eds) Cesarean Section. Clinical Perspectives in Obstetrics and Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2482-2_10

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  • DOI: https://doi.org/10.1007/978-1-4612-2482-2_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7556-5

  • Online ISBN: 978-1-4612-2482-2

  • eBook Packages: Springer Book Archive

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