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Cryptosporidium sp. and Cyclospora sp

  • Dickson D. Despommier
  • Robert W. Gwadz
  • Peter J. Hotez

Abstract

The genera Cryptosporidium and Cyclospora constitute two groups of parasitic protozoans, all of which can cause transient diarrhea. Cryptosporidium occurs in a wide variety of hosts, such as sheep, cattle, birds, rodents, and primates including humans, whereas Cyclospora occurrence has so far been described only in humans.1 Experimental evidence based on cross-infectivity of Cryptosporidium recovered from different hosts suggests that the number of species of this organism is limited, with C. parvum being the dominant one in nature.2 It seems that many species of animals harboring Cryptosporidium act as reservoirs of the human infection. The organism is worldwide in distribution. It is considered a pathogen for all ages and both sexes in humans, in whom it causes subclinical infection or a mild diarrhea.

Keywords

Watery Diarrhea Public Water Supply Congenital Toxoplasmosis Plasmodium Malariae Parasite Life Cycle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Navin TR, Juranek DD: Cryptosporidium: clinical, epidemiologic, and parasitologic review. Rev Infect Dis 6: 313–327, 1984PubMedCrossRefGoogle Scholar
  2. 2.
    Tzipori S, Angus TW, Grey EW et al: Diarrhea in lambs experimentally infected with Cryptosporidium isolated from calves. Am J Vet Res 42: 1400–1404, 1981PubMedGoogle Scholar
  3. 3.
    Current WL, Reese NC, Ernest JV, et al: Human cryptosporidiosis in immunocompetent and immunodeficient persons. N Engl J Med 308: 1252–1257, 1983PubMedCrossRefGoogle Scholar
  4. 4.
    Tyzzer EE: A sporozoan found in the peptic glands of the common mouse. Proc Soc Exp Biol Med 5; 12–13, 1907Google Scholar
  5. 5.
    Slavin D: Cryptosporidium meleagridis (sp. nov.) J Comp Pathol 65: 262–266, 1955PubMedGoogle Scholar
  6. 6.
    Nime FA, Burek JD, Page DL, et al: Acute enterocolitis in a human being infected with the protozoan Cryptosporidium. Gastroenterology 70: 592–598, 1976PubMedGoogle Scholar
  7. 7.
    Meisel JE, Perera DR, Meloigro C, et al: Overwhelming watery diarrhea associated with Cryptosporidium in an immunosuppressed patient. Gastroenterology 70: 1156–1160, 1976PubMedGoogle Scholar
  8. 8.
    Bird RG, Smith MD: Cryptosporidiosis in man: parasite life cycle and fine structural pathology. J Pathol 132:217, 1980PubMedCrossRefGoogle Scholar
  9. 9.
    Current WL, Haynes TB: Complete development of cryptosporidiosis in cell culture. Science 224: 603–605, 1984PubMedCrossRefGoogle Scholar
  10. 10.
    Lefkowitch JH, Krumholtz S, Kuo-Ching F-C, et al: Cryptosporidiosis of the human small intestine: a light and electron microscopic study. Hum Pathol 15: 746–752, 1984PubMedCrossRefGoogle Scholar
  11. 11.
    Stemmerman GN, Hayashi T, Glober GA, et al: Cryptosporidiosis: report of a fatal case complicated by disseminated toxoplasmosis. Am J Trop Med Hyg 69: 637–642, 1980Google Scholar
  12. 12.
    Slope KS, Dormashkin RR, Bird RB, et al: Chronic malabsorption due to cryptosporidiosis in a child with immunoglobulin deficiency. Gut 23: 80–82, 1982CrossRefGoogle Scholar
  13. 13.
    Soave R, Danne RL, Lonig CL, et al: Cryptosporidiosis in homosexual men. Ann Intern Med 100: 504–511, 1984PubMedGoogle Scholar
  14. 14.
    Petersen C: Cryptosporidiosis in patients infected with the human immunodeficiency virus. Clin Infect Dis 15: 903–909, 1992PubMedCrossRefGoogle Scholar
  15. 15.
    Ortega YR, Sterling CR, Gilman RH, et al: Cyclospora species—a new protozoan pathogen of humans. N Engl J Med 328: 1308–1312, 1993PubMedCrossRefGoogle Scholar
  16. 16.
    Ma P, Soave R: Three-step stool examination for cryptosporidiosis in 10 homosexual men with protracted watery diarrhea. J Infect Dis 147: 824–829, 1983PubMedCrossRefGoogle Scholar
  17. 17.
    Armitage K, Flanigan T, Carey J, et al: Treatment of cryptosporidiosis with paromomycin. Arch Intern Med 152: 2497–2499, 1992PubMedCrossRefGoogle Scholar
  18. 18.
    Nord J, May P, DiJohn D, et al: Treatment with bovine hyperimmune colostrum of cryptosporidial diarrhea in AIDS patients. AIDS 4: 581–584, 1990PubMedCrossRefGoogle Scholar
  19. 19.
    Ungar BLOP, Ward DJ, Fayer R, Quinn CA: Cessation of Cryptosporidium-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum. Gastroenterology 98: 486–489, 1990PubMedGoogle Scholar
  20. 20.
    Vargas SL, Shenep JL, Flynn PM, et al: Azithromycin for treatment of severe Cryptosporidium diarrhea in two children with cancer. J Pediatr 123: 154–156, 1993PubMedCrossRefGoogle Scholar
  21. 21.
    Crawford FG, Vermund SH: Asymptomatic Cryptosporidium infection: a review. Pediatr Rev Commun 5: 11–19, 1990Google Scholar
  22. 22.
    Crawford FG, Vermund SH: Parasitic infections in day care centers. Pediatr Infect Dis J 6: 744–749, 1987PubMedCrossRefGoogle Scholar
  23. 23.
    Hayes EB, Matte TD, O’Brien TR, et al: Large community outbreak of cryptosporidiosis due to contamination of a filtered public water supply. N Engl J Med 320: 1372–1376, 1989PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1995

Authors and Affiliations

  • Dickson D. Despommier
    • 1
  • Robert W. Gwadz
    • 2
  • Peter J. Hotez
    • 3
  1. 1.College of Physicians and SurgeonsColumbia University, Presbyterian HospitalNew YorkUSA
  2. 2.Laboratory of Malaria Research, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  3. 3.Yale University School of MedicineNew HavenUSA

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