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Speculations on the Origin of BSE and the Epidemiology of CJD

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Bovine Spongiform Encephalopathy

Part of the book series: Serono Symposia USA Norwell, Massachusetts ((SERONOSYMP))

Abstract

The occurrence of bovine spongiform encephalopathy (BSE) has dramatically increased public awareness of the transmissible spongiform encephalopathies (TSEs) and stimulated a widespread interest in the current state of knowledge.

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References

  1. Wells GAH, Scott AC, Johnson CT, et al. A novel progressive spongiform encephalopathy in cattle. Vet Rec 1987;121:419–420.

    Article  PubMed  CAS  Google Scholar 

  2. Gajdusek DC. Unconventional viruses and the origin and disappearance of Kuru. Science 1977;197:943–960.

    Article  PubMed  CAS  Google Scholar 

  3. Marsh RF, Hanson RP. On the origin of transmissible mink encephalopathy. In: Prusiner SB, Hadlow WJ, eds. Slow transmissible diseases of the nervous system, vol 1. New York. Academic Press, 1979:451–460.

    Google Scholar 

  4. Wilesmith JW, Wells GAH, Cranwell MP, Ryan JMB. Bovine spongiform encephalopathy: epidemiological studies. Vet Rec 1988;123:638–644.

    PubMed  CAS  Google Scholar 

  5. The Bovine Spongiform Encephalopathy Order 1988. Statutory Instrument No. 1039. London: Her Majesty’s Stationary Office, 1988.

    Google Scholar 

  6. Wilesmith JW. The epidemiology of bovine spongiform encephalopathy. Semin Virol 1991;2:239–245.

    Google Scholar 

  7. Wilesmith JW, Ryan JBM, Hueston WD, Hoinville LJ. Bovine spongiform encephalopathy: epidemiological features 1985–1990. Vet Rec 1992;130:90–94.

    Article  PubMed  CAS  Google Scholar 

  8. Wilesmith JW, Ryan JBM, Hueston WD. Bovine spongiform encephalopathy: case-control studies of calf feeding practices and meat and bone meal inclusion in proprietary concentrates. Res Vet Sci 1992;52:325–331.

    Article  PubMed  CAS  Google Scholar 

  9. Wilesmith JW. Bovine spongiform encephalopathy: epidemiological factors associated with the emergence of an important new animal pathogen in Great Britain. Semin Virol 1994;5:179–187.

    Article  Google Scholar 

  10. Kimberlin RH. Bovine spongiform encephalopathy: an appraisal of the current epidemic in the U.K. Intervirology 1993;35:208–218.

    PubMed  CAS  Google Scholar 

  11. Kimberlin RH, Wilesmith JW. Bovine spongiform encephalopathy (BSE): epidemiology, low dose exposure and risks. Ann NY Acad Sci 1994;724:210–220.

    Article  PubMed  CAS  Google Scholar 

  12. Bradley R, Marchant B, eds. Transmissible spongiform encephalopathies. Proceedings of a consultation on BSE with the Scientific Veterinary Committee of the Commission of the European Communities, Brussels; 1993 Sept 14–15; European Commission Document VI/4131/94-EN. Brussels, 1994.

    Google Scholar 

  13. Wilesmith JW, Ryan JBM, Atkinson MJ. Bovine spongiform encephalopathy: epidemiological studies on the origin. Vet Rec 1991;128:199–203.

    Article  PubMed  CAS  Google Scholar 

  14. Klitzman RL, Alpers MP, Gajdusek DC. The natural incubation period of Kuru and the episodes of transmission in three clusters of patients. Neuroepidemiology 1984;3:3–20.

    Article  Google Scholar 

  15. Kimberlin RH. Unconventional “slow” viruses. In: Collier LH, Timbury MC, eds. Topley and Wilson’s principles of bacteriology, virology and immunity, vol 4. 8th ed. London: Edward Arnold, 1990:671–693.

    Google Scholar 

  16. Detwiler LA. Scrapie. Sci Tech Rev Int Off Epiz 1992;11:491–537.

    CAS  Google Scholar 

  17. Williams ES, Young S. Spongiform encephalopathies in Cervidae. Sci Tech Rev Int Off Epiz 1992;11:551–567.

    CAS  Google Scholar 

  18. Bruce ME, Chree A, McConnell I, Foster J, Pearson G, Fraser H. Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier. Philos Trans R Soc Lond [B] 1994;343:405–411.

    Article  CAS  Google Scholar 

  19. Gibbs CJ Jr, Safar J, Ceroni M, Di Martino A, Clark WW, Hourrigan JL. Experimental transmission of scrapie to cattle. Lancet 1990;335:1275.

    Article  PubMed  Google Scholar 

  20. Cutlip RC, Miller JM, Race RE, et al. Intracerebral transmission of scrapie to cattle. J Infect Dis 1994;169:814–820.

    Article  PubMed  CAS  Google Scholar 

  21. Kimberlin RH. A scientific evaluation of research into bovine spongiform encephalopathy (BSE). In: Bradley R, Marchant B, eds. Transmissible spongiform encephalopathies. Proceedings of a consultation on BSE with the Scientific Veterinary Committee of the Commission of the European Communities, Brussels; 1993 Sept 14–15; European Commission Document VI/4131/94-EN: Brussels, 1994:455–477.

    Google Scholar 

  22. Bruce ME, McConnell I, Fraser H, Dickinson AG. The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implication for the nature of the agent and host control of pathogenesis. J Gen Virol 1991;72: 595–603.

    Article  PubMed  CAS  Google Scholar 

  23. Dickinson AG, Outram GW. Pathogenesis of experimental scrapie. In: Bock G, Marsh J, eds. Novel Infectious Agents and the Central Nervous System. Ciba Foundation Symposium No. 135. Chichester: Wiley, 1988;63–83.

    Google Scholar 

  24. Foster JD, Dickinson AG. Genetic control of scrapie in Cheviot and Suffolk sheep. Vet Rec 1988;123:159.

    Article  PubMed  CAS  Google Scholar 

  25. Prusiner SB. Molecular biology and genetics of prion diseases. Philos Trans R Soc Lond [B] 1994;343:447–463.

    Article  CAS  Google Scholar 

  26. Weissmann C, Bueler H, Fischer M, Sauer A, Aguet M. Susceptibility to scrapie in mice is dependent on PrPc. Philos Trans R Soc Lond [B] 1994;343: 431–433.

    Article  CAS  Google Scholar 

  27. Kimberlin RH, Walker CA. Incubation periods in six models of intraperitoneally injected scrapie depend mainly on the dynamics of agent replication within the nervous system and not the lymphoreticular system. J Gen Virol 1988;69:2953–2960.

    Article  PubMed  Google Scholar 

  28. Bruce ME. Agent replication dynamics in a long incubation period model of mouse scrapie. J Gen Virol 1985;66:2517–2522.

    Article  PubMed  Google Scholar 

  29. Collis SC, Kimberlin RH. Long term persistence of scrapie infection in mouse spleens in the absence of clinical disease. FEMS Microbiol Lett 1985;29:111–114.

    Article  Google Scholar 

  30. Goldmann G, Hunter N, Smith G, Foster J, Hope J. PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie. J Gen Virol 1994;75:989–995.

    Article  PubMed  CAS  Google Scholar 

  31. Westaway D, Cooper C, Turner S, Da Costa M, Carlson GA, Prusiner SB. Structure and polymorphism of the mouse prion protein gene. Proc Natl Acad Sci USA 1994;91:6418–6422.

    Article  PubMed  CAS  Google Scholar 

  32. Collinge J, Palmer M. Molecular genetics of human prion diseases. Philos Trans R Soc Lond [B] 1994;343:371–378.

    Article  CAS  Google Scholar 

  33. Goldfarb LG, Brown P, Cervenakova L, Gajdusek DC. Genetic analysis of Creutzfeldt-Jakob disease and related disorders. Philos Trans R Soc Lond [B] 1994;343:379–384.

    Article  CAS  Google Scholar 

  34. Hunter N, Goldmann W, Smith G, Hope J. Frequencies of PrP gene variants in healthy cattle and cattle with BSE in Scotland. Vet Rec 1994;135:400–403.

    Article  PubMed  CAS  Google Scholar 

  35. Dawson M, Wells GAH, Parker BNJ, et al. Transmission studies of BSE in cattle, pigs and domestic fowl. In: Bradley R, Marchant B, eds. Transmissible spongiform encephalopathies. Proceedings of a Consultation on BSE with the Scientific Veterinary Committee of the Commission of the European Communities, Brussels; 1993 Sept 14–15; European Commission Document VI/4131/94-EN: Brussels, 1994:161–167.

    Google Scholar 

  36. Bruce ME, Dickinson AG. Biological evidence that scrapie agent has an independent genome. J Gen Virol 1987;68:79–89.

    Article  PubMed  Google Scholar 

  37. Kimberlin RH, Walker CA, Fraser H. The genomic identity of different strains of mouse scrapie is expressed in hamsters and preserved on reisolation in mice. J Gen Virol 1989;70:2017–2025.

    Article  PubMed  Google Scholar 

  38. Kimberlin RH, Cole S, Walker CA. Transmissible mink encephalopathy (TME) in Chinese hamsters: identification of two strains of TME and comparisons with scrapie. Neuropathol Appl Neurobiol 1986;12:197–206.

    Article  PubMed  CAS  Google Scholar 

  39. Kimberlin RH. Bovine spongiform encephalopathy. Sci Tech Rev Int Off Epiz 1992,11:347–390 (English), 391–439 (French), 441–89 (Spanish).

    CAS  Google Scholar 

  40. Kimberlin RH, Walker CA. Pathogenesis of scrapie in mice after intragastric infection. Virus Res 1989;12:213–220.

    Article  PubMed  CAS  Google Scholar 

  41. Hadlow WJ, Race RE, Kennedy RC. Temporal distribution of transmissible mink encephalopathy virus in mink inoculated subcutaneously. J Virol 1987; 61:3235–3240.

    PubMed  CAS  Google Scholar 

  42. Hadlow WJ, Kennedy RC, Race RE. Natural infection of Suffolk sheep with scrapie virus. J Infect Dis 1982;146:657–664.

    Article  PubMed  CAS  Google Scholar 

  43. Fraser H, Foster JD. Transmission to mice, sheep and goats and bioassay of bovine tissues. In: Bradley R, Marchant B, eds. Transmissible spongiform encephalopathies. Proceedings of a Consultation on BSE with the Scientific Veterinary Committee of the Commission of the European Communities, Brussels; 1993 Sept 14–15; European Commission Document VI/4131/94-EN: Brussels, 1994:145–159.

    Google Scholar 

  44. Bleem AM, Crom RL, Francy DB, Hueston WD, Kopral C, Walker K. Risk factors and surveillance for bovine spongiform encephalopathy in the United States. J Am Vet Med Assoc 1994;204:644–651.

    PubMed  CAS  Google Scholar 

  45. Marsh RF, Bessen RA, Lehmann S, Hartsough GR. Epidemiological and experimental studies on a new incident of transmissible mink encephalopathy. J Gen Virol 1991;72:589–594.

    Article  PubMed  Google Scholar 

  46. Robinson MM. Transmissible encephalopathy research in the United States. In: Bradley R, Marchant B, eds. Transmissible spongiform encephalopathies. Proceedings of a Consultation on BSE with the Scientific Veterinary Committee of the Commission of the European Communities, Brussels; 1993, Sept 14–15; European Commission Document VI/4131/94-EN: Brussels, 1994: 261–267.

    Google Scholar 

  47. Clark AM, Moar JAE. Scrapie: a clinical assessment. Vet Rec 1992;130:377–378.

    Article  PubMed  CAS  Google Scholar 

  48. Kimberlin RH. The aetiology and genetic control of natural scrapie. Nature (Lond) 1979;278:303–304.

    Article  CAS  Google Scholar 

  49. Brown P, Gibbs CJ Jr, Rodgers-Johnson P, et al. Human spongiform encephalopathy: The National Institutes of Health series of 300 cases of experimentally transmitted disease. Ann Neurol 1994;35:513–529.

    Article  PubMed  CAS  Google Scholar 

  50. Muramoto T, Kitamoto T, Tateishi J, Goto I. Successful transmission of Creutzfeldt-Jakob disease from human to mouse verified by prion protein accumulation in mouse brains. Brain Res 1992;599:309–316.

    Article  PubMed  CAS  Google Scholar 

  51. Brown P, Preece MA, Will RG. “Friendly fire” in medicine: hormones, homografts, and Creutzfeldt-Jakob disease. Lancet 1992;340:24–27.

    Article  PubMed  CAS  Google Scholar 

  52. Hsiao K, Baker HF, Crow TJ, et al. Linkage of a prion protein missense variant to Gerstmann-Straussler syndrome. Nature (Lond) 1989;338:342–345.

    Article  CAS  Google Scholar 

  53. Gabizon R, Rosenman H, Meiner Z, et al. Mutation in codon 129 of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease. Philos Trans R Soc Lond [B] 1994;343:385–390.

    Article  CAS  Google Scholar 

  54. Hsiao KK, Groth D, Scott M, et al. Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein. Proc Natl Acad Sci USA 1994;91:9126–9130.

    Article  PubMed  CAS  Google Scholar 

  55. Brown P, Cathala F, Raubertas RF, Gajdusek DC, Castaigne P. The epidemiology of Creutzfeldt-Jakob disease: conclusion of a 15-year investigation in France and review of the world literature. Neurology 1987;37:895–904.

    PubMed  CAS  Google Scholar 

  56. Will RG, Matthews WB, Smith PG, Hudson C. A retrospective study of Creutzfeldt-Jakob disease in England and Wales 1970–1979 II: epidemiology. J Neurol Neurosurg Psychiatry 1986;49:749–755.

    Article  PubMed  CAS  Google Scholar 

  57. Palmer MS, Collinge J. Mutations and polymorphisms in the prion protein gene. Human Mut 1993;2:168–173.

    Article  CAS  Google Scholar 

  58. Wood JLN, Hall AJ. Creutzfeldt-Jakob disease. Lancet 1991;338:182–183.

    Article  PubMed  CAS  Google Scholar 

  59. Bellman MH, Dick G. Surveillance of subacute sclerosing panencephalitis. Br Med J 1980; 281:393–394.

    PubMed  CAS  Google Scholar 

  60. Stoner GL, Walker DL, Webster H deF. Age distribution of progressive multifocal leukoencephalopathy. Acta Neurol Scand 1988;78:307–312.

    Article  PubMed  CAS  Google Scholar 

  61. Manuelidis EE, Manuelidis L. A transmissible Creutzfeldt-Jakob disease-like agent is prevalent in the human population. Proc Natl Acad Sci USA 1993;90:7724–7728.

    Article  PubMed  CAS  Google Scholar 

  62. Godec MS, Asher DM, Kozachuk WE, et al. Blood buffy coat from Alzheimer’s disease patients and their relatives does not transmit spongiform encephalopathy to hamsters. Neurology 1994;44:1111–1115.

    PubMed  CAS  Google Scholar 

  63. Telling GC, Scott M, Hsiao KK, et al. Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein. Proc Natl Acad Sci USA 1994;91:9936–9940.

    Article  PubMed  CAS  Google Scholar 

  64. Monari L, Chen SG, Brown P, et al. Fatal familial insomnia and familial Creutzfeldt-Jakob disease: different prion proteins determined by a DNA polymorphism. Proc Natl Acad Sci USA 1994;91:2839–2842.

    Article  PubMed  CAS  Google Scholar 

  65. Esmonde TFG, Will RG, Slattery JM, et al. Creutzfeldt-Jakob disease and blood transfusion. Lancet 1993;341:205–207.

    Article  PubMed  CAS  Google Scholar 

  66. The Bovine Offal (Prohibition) Regulations 1989. Statutory Instrument No. 2061. London: HMSO, 1989.

    Google Scholar 

  67. Alperovitch A, Brown P, Weber T, Pocchiari M, Hofman A, Will R. Incidence of Creutzfeldt-Jakob disease in Europe in 1993. Lancet 1994;343: 918.

    Article  PubMed  CAS  Google Scholar 

  68. Kirkwood JK, Cunningham AA. Epidemiological observations on spongiform encephalopathies in captive wild animals in the British Isles. Vet Rec 1994;135:296–303.

    Article  PubMed  CAS  Google Scholar 

  69. The Bovine Spongiform Encephalopathy (No. 2) (Amendment) Order 1990. Statutory Instrument No. 1930. London: Her Majesty’s Stationary Office, 1990.

    Google Scholar 

  70. European Commission Decision 94/382 of 27 June 1994.

    Google Scholar 

  71. European Commission Decision 94/381 of 27 June 1994.

    Google Scholar 

  72. Harris DA, Falls DL, Johnson FA, Fischbach GD. A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity. Proc Natl Acad Sci USA 1991;88:7664–7668.

    Article  PubMed  CAS  Google Scholar 

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Kimberlin, R.H. (1996). Speculations on the Origin of BSE and the Epidemiology of CJD. In: Gibbs, C.J. (eds) Bovine Spongiform Encephalopathy. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2406-8_13

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  • DOI: https://doi.org/10.1007/978-1-4612-2406-8_13

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7527-5

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