Growth Hormone Releasing Hormone: Behavioral Evidence for Direct Central Actions
Growth hormone releasing hormone (GHRH) peptides have been isolated and characterized from human pancreatic tumor (1, 2) and from hypothalami of several species including rat and human (3–6). GHRH peptides have strong homology with peptides of the glucagon, vasoactive intestinal polypeptide, and PHI-27 family. Many of the GHRH neurons have their cell bodies in the arcuate nucleus of the hypothalamus with fibers extending into the median eminence (7–9). GHRH-containing terminals in the median eminence are located proximal to capillaries that drain into the hypophysial portal blood system. It is through this system that GHRH stimulates the release of growth hormone from cells in the anterior pituitary gland (10). The characterization and synthesis of GHRH represents a significant development and has opened important new avenues for the direct study of GHRH function.
KeywordsGrowth Hormone Anorexia Nervosa Median Eminence Growth Hormone Response Increase Food Intake
Unable to display preview. Download preview PDF.
- 9.Bloch B, Brazeau P, Ling N, Bohlen P, Esch F, Wehrenberg WB, Benoit R, Bloom F. Immunohistochemical detection of growth hormone-releasing factor in the brain. Nature 1983;263:251–7.Google Scholar
- 29.Rezek MT, Havlicek V, Hughes R, Friesen H. Central site of action of somatostatin (SRIF): role of hippocampus. Neuropsychology 1976;15:499–504.Google Scholar
- 42.Vaccarino FJ, Feifel D, Rivier J, Vale W. Antagonism of central growth hormone-releasing factor activity selectively attenuates dark-onset feeding in rats. J Neurosci 1991;ll(12):3924–7.Google Scholar