Growth Hormone Releasing Hormone: Behavioral Evidence for Direct Central Actions

  • Franco J. Vaccarino
  • Sidney H. Kennedy
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)

Abstract

Growth hormone releasing hormone (GHRH) peptides have been isolated and characterized from human pancreatic tumor (1, 2) and from hypothalami of several species including rat and human (3–6). GHRH peptides have strong homology with peptides of the glucagon, vasoactive intestinal polypeptide, and PHI-27 family. Many of the GHRH neurons have their cell bodies in the arcuate nucleus of the hypothalamus with fibers extending into the median eminence (7–9). GHRH-containing terminals in the median eminence are located proximal to capillaries that drain into the hypophysial portal blood system. It is through this system that GHRH stimulates the release of growth hormone from cells in the anterior pituitary gland (10). The characterization and synthesis of GHRH represents a significant development and has opened important new avenues for the direct study of GHRH function.

Keywords

Carbohydrate Attenuation Polypeptide Norepinephrine Hyperglycemia 

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Copyright information

© Springer-Verlag New York, Inc. 1996

Authors and Affiliations

  • Franco J. Vaccarino
  • Sidney H. Kennedy

There are no affiliations available

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