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The Immunology of Leishmania Major Infection in Mice

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Genetic Models of Immune and Inflammatory Diseases

Part of the book series: Serono Symposia USA ((SERONOSYMP))

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Abstract

The immunology of Leishmania major infection has been extensively characterized using inbred mouse strains. Control of disease is exquisitely T-cell dependent; neither nude nor scid mice are capable of restricting dissemination of the parasite and death without T-cell reconstitution (1–3). Further, control of infection is CD4+ T-cell dependent, since disease is fatal in major histocompatibility complex (MHC) class II-deficient mice that lack CD4+ T cells (4), but is readily controlled in MHC class I-deficient mice that lack CD8+ T cells (5). Appropriate parasite-specific CD4+ T-cell lines and clones were fully capable of restoring control of infection to otherwise deficient nude, SCID, or irradiated recipients (2, 3, 6, 7).

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Authors
  1. Richard M. Locksley
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Editors and Affiliations

  1. Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, 02115, Boston, MA, USA

    Abul K. Abbas M.D.

  2. Section of Immunobiology, Yale University School of Medicine, 06520, New Haven, CT, USA

    Richard A. Flavell Ph.D.

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© 1996 Springer-Verlag New York, Inc.

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Locksley, R.M. (1996). The Immunology of Leishmania Major Infection in Mice. In: Abbas, A.K., Flavell, R.A. (eds) Genetic Models of Immune and Inflammatory Diseases. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2376-4_9

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  • DOI: https://doi.org/10.1007/978-1-4612-2376-4_9

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7520-6

  • Online ISBN: 978-1-4612-2376-4

  • eBook Packages: Springer Book Archive

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