The Immunology of Leishmania Major Infection in Mice

  • Richard M. Locksley
Part of the Serono Symposia USA book series (SERONOSYMP)


The immunology of Leishmania major infection has been extensively characterized using inbred mouse strains. Control of disease is exquisitely T-cell dependent; neither nude nor scid mice are capable of restricting dissemination of the parasite and death without T-cell reconstitution (1–3). Further, control of infection is CD4+ T-cell dependent, since disease is fatal in major histocompatibility complex (MHC) class II-deficient mice that lack CD4+ T cells (4), but is readily controlled in MHC class I-deficient mice that lack CD8+ T cells (5). Appropriate parasite-specific CD4+ T-cell lines and clones were fully capable of restoring control of infection to otherwise deficient nude, SCID, or irradiated recipients (2, 3, 6, 7).


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© Springer-Verlag New York, Inc. 1996

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  • Richard M. Locksley

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