Activating Mutations of the Luteinizing Hormone Receptor Gene in Familial Testotoxicosis

  • Andrew Shenker
  • Shinji Kosugi
Part of the Serono Symposia USA Norwell, Massachusetts book series (SERONOSYMP)


Heptahelical, membrane-spanning cell-surface receptors utilize he-terotrimeric guanine nucleotide binding proteins (G proteins) to transmit extracellular signals to cellular effectors (1–4). Diverse stimuli, including photons, hormones, neurotransmitters, odorants, proteases, and ions, trigger conformational changes in the receptor transmembrane helices that are relayed to the cytoplasmic surface, leading to G protein activation (Fig. 20.1A).


Leydig Cell Precocious Puberty Nephrogenic Diabetes Insipidus Luteinizing Hormone Receptor Thyrotropin Receptor 
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© Springer-Verlag New York, Inc. 1996

Authors and Affiliations

  • Andrew Shenker
  • Shinji Kosugi

There are no affiliations available

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