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Nucleocytoplasmic Shuttling of Estrogen Receptors is Blocked by “Pure Anti-Estrogens”

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Book cover Hormonal Carcinogenesis II

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Abstract

The estrogen receptor belongs to a large family of nuclear receptors whose activity as a transcription factor depends on the binding of a hormonal ligand (1). As with other steroid receptors, in the absence of ligand the estrogen receptor is found in an oligomeric complex that is unable to bind to DNA (2–4). Following hormone binding, the complex is dissociated to allow receptor dimerization, high-affinity DNA binding, and transcriptional activation (5, 6). In the estrogen receptor, there are at least two regions called activation functions, or AFs, which are required to stimulate transcription (7, 8). The relative activities of AF-1, located in the N-terminal domain, and AF-2, in the C-terminal hormone binding domain, vary according to the responsive promoter and target cells.

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Authors
  1. Sophie Dauvois
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  2. Malcolm G. Parker
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Editor information

Editors and Affiliations

  1. Division of Etiology and Prevention of Hormonal Cancers, Hormonal Carcinogenesis Laboratory, University of Kansas Cancer Center, Kansas City, Kansas, USA

    J. Jonathan Li Ph.D. (Professor of Pharmacology, Toxicology, and Therapeutics, Director) (Professor of Pharmacology, Toxicology, and Therapeutics, Director)

  2. Hormonal Carcinogenesis Laboratory, University of Kansas Cancer Center, Kansas City, Kansas, USA

    Sara Antonia Li Ph.D. (Associate Professor of Pharmacology, Toxicology, and Therapeutics) (Associate Professor of Pharmacology, Toxicology, and Therapeutics)

  3. Department of Medical Nutrition, Center for Biotechnology, NOVUM, Huddinge University Hospital, Huddinge, Sweden

    Jan-Åke Gustafsson M.D., Ph.D. (Professor and Chairman, Director) (Professor and Chairman, Director)

  4. Department of Molecular and Cell Biology, Cancer Research Center, University of California, Berkeley, California, USA

    Satyabrata Nandi Ph.D. (Professor of Cell and Development Biology) (Professor of Cell and Development Biology)

  5. Division of Cancer Etiology, Chemical and Physical Carcinogenesis Program, National Cancer Institute, Rockville, Maryland, USA

    Lea I. Sekely Ph.D. (Program Director) (Program Director)

  6. University of Kansas Medical Center, Kansas City, Kansas, USA

    J. Jonathan Li Ph.D. (Professor of Pharmacology, Toxicology, and Therapeutics, Director) & Sara Antonia Li Ph.D. (Associate Professor of Pharmacology, Toxicology, and Therapeutics) (Professor of Pharmacology, Toxicology, and Therapeutics, Director) &  (Associate Professor of Pharmacology, Toxicology, and Therapeutics)

  7. National Institutes of Health, Rockville, Maryland, USA

    Lea I. Sekely Ph.D. (Program Director) (Program Director)

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© 1996 Springer-Verlag New York, Inc.

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Dauvois, S., Parker, M.G. (1996). Nucleocytoplasmic Shuttling of Estrogen Receptors is Blocked by “Pure Anti-Estrogens”. In: Li, J.J., Li, S.A., Gustafsson, JÅ., Nandi, S., Sekely, L.I. (eds) Hormonal Carcinogenesis II. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2332-0_8

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  • DOI: https://doi.org/10.1007/978-1-4612-2332-0_8

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7506-0

  • Online ISBN: 978-1-4612-2332-0

  • eBook Packages: Springer Book Archive

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