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Molecular Cytogenetics of Solid Tumor Progression

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Hormonal Carcinogenesis II

Abstract

Solid tumors are thought to develop and progress by a multi-step process, involving numerous genetic events during tumor evolution (1). Even in cases of familial inheritance, when an individual may already be predisposed to tumorigenesis by carrying a mutation in one allele of a tumor suppressor gene (retinoblastoma, p53, BRCA1, etc.), it is likely that several additional genetic events are required during the progression of a tumor clone from normal epithelium through premalignant, invasive, and metastatic stages. Characterization of the mechanisms underlying tumor progression, and of the genetic events specific to individual tumor types, will lead to improved clinical management and possibly to new therapeutic approaches.

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Authors
  1. Frederic M. Waldman
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  2. Guido Sauter
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  3. Jorma Isola
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  4. Olli Kallioniemi
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  5. Anne Kallioniemi
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Editor information

Editors and Affiliations

  1. Division of Etiology and Prevention of Hormonal Cancers, Hormonal Carcinogenesis Laboratory, University of Kansas Cancer Center, Kansas City, Kansas, USA

    J. Jonathan Li Ph.D. (Professor of Pharmacology, Toxicology, and Therapeutics, Director) (Professor of Pharmacology, Toxicology, and Therapeutics, Director)

  2. Hormonal Carcinogenesis Laboratory, University of Kansas Cancer Center, Kansas City, Kansas, USA

    Sara Antonia Li Ph.D. (Associate Professor of Pharmacology, Toxicology, and Therapeutics) (Associate Professor of Pharmacology, Toxicology, and Therapeutics)

  3. Department of Medical Nutrition, Center for Biotechnology, NOVUM, Huddinge University Hospital, Huddinge, Sweden

    Jan-Åke Gustafsson M.D., Ph.D. (Professor and Chairman, Director) (Professor and Chairman, Director)

  4. Department of Molecular and Cell Biology, Cancer Research Center, University of California, Berkeley, California, USA

    Satyabrata Nandi Ph.D. (Professor of Cell and Development Biology) (Professor of Cell and Development Biology)

  5. Division of Cancer Etiology, Chemical and Physical Carcinogenesis Program, National Cancer Institute, Rockville, Maryland, USA

    Lea I. Sekely Ph.D. (Program Director) (Program Director)

  6. University of Kansas Medical Center, Kansas City, Kansas, USA

    J. Jonathan Li Ph.D. (Professor of Pharmacology, Toxicology, and Therapeutics, Director) & Sara Antonia Li Ph.D. (Associate Professor of Pharmacology, Toxicology, and Therapeutics) (Professor of Pharmacology, Toxicology, and Therapeutics, Director) &  (Associate Professor of Pharmacology, Toxicology, and Therapeutics)

  7. National Institutes of Health, Rockville, Maryland, USA

    Lea I. Sekely Ph.D. (Program Director) (Program Director)

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© 1996 Springer-Verlag New York, Inc.

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Waldman, F.M., Sauter, G., Isola, J., Kallioniemi, O., Kallioniemi, A. (1996). Molecular Cytogenetics of Solid Tumor Progression. In: Li, J.J., Li, S.A., Gustafsson, JÅ., Nandi, S., Sekely, L.I. (eds) Hormonal Carcinogenesis II. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2332-0_7

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  • DOI: https://doi.org/10.1007/978-1-4612-2332-0_7

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7506-0

  • Online ISBN: 978-1-4612-2332-0

  • eBook Packages: Springer Book Archive

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