Antiproliferative Activity of Luteolin, a Naturally-Occurring Edible Plant Flavone, Against Estrone-Induced Cell Proliferation in the Mammary Gland of Noble Rats
In this study, we present evidence that estrone treatment leads to an imbalance in mammary gland cell proliferation in the Noble rat, which can be blocked by the naturally-occurring plant flavone, luteolin. Estrone treatment drastically increased cell proliferation, while luteolin treatment significantly inhibited estrone-induced cell proliferation. Increased cell proliferation, by providing the necessary milieu for promoting genetic instability, may play a key role in estrone-induced mammary cancer in the Noble rat. The antiproliferative action of luteolin suggests that it may play a protective role against estrone-induced mammary carcinogenesis in this species.
KeywordsMammary Gland Proliferate Cell Nuclear Antigen Increase Cell Proliferation Mammary Cancer Mammary Carcinogenesis
Unable to display preview. Download preview PDF.
- 1.Pike M, Spicer D (1992) Endogenous estrogen and progesterone as the major determinants of breast cancer risk: Prospects for control by natural and technological means. In Li JJ, Nandi S, Li SA (eds): Hormonal Carcinogenesis. New York: Springer-Verlag, pp 209–216.Google Scholar
- 2.Poliner F (1993) A holistic approach to breast cancer research. Environ Health Perspect 101: 116–120.Google Scholar
- 3.Marshall E (1993) Search for a Killer: Focus shifts from fat to hormones. Science 259: 518–520.Google Scholar
- 4.IARC (1979) Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Sex hormones. IARC Monographs 21: 173–221.Google Scholar
- 6.Cutts JH (1964) Estrone-induced mammary tumors in the rat. II. Effects of alterations in the hormonal environment on tumor induction, behavior, and growth. Cancer Res 24: 1124–1130.Google Scholar
- 9.Foley J, Ton T, Maronpot R, et al. (1994) Proliferating Cell Nuclear Antigen (PCNA): Comparison to tritiated thymidine (3H-TdR) as a marker of proliferating hepatocytes in rats. Environ Health Perspect, in press.Google Scholar
- 11.Martin S, Pike M, Ross R, et al. (1990) Increased cell division as a cause of human cancer. Cancer Res 50: 7415–7421.Google Scholar