Antiproliferative Activity of Luteolin, a Naturally-Occurring Edible Plant Flavone, Against Estrone-Induced Cell Proliferation in the Mammary Gland of Noble Rats

  • Michael B. Holland
  • Deodutta T. E. Roy
Conference paper


In this study, we present evidence that estrone treatment leads to an imbalance in mammary gland cell proliferation in the Noble rat, which can be blocked by the naturally-occurring plant flavone, luteolin. Estrone treatment drastically increased cell proliferation, while luteolin treatment significantly inhibited estrone-induced cell proliferation. Increased cell proliferation, by providing the necessary milieu for promoting genetic instability, may play a key role in estrone-induced mammary cancer in the Noble rat. The antiproliferative action of luteolin suggests that it may play a protective role against estrone-induced mammary carcinogenesis in this species.


Mammary Gland Proliferate Cell Nuclear Antigen Increase Cell Proliferation Mammary Cancer Mammary Carcinogenesis 
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Copyright information

© Springer-Verlag New York, Inc. 1996

Authors and Affiliations

  • Michael B. Holland
  • Deodutta T. E. Roy

There are no affiliations available

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