A Cell Cycle Regulator and Cancer

  • Alexander C. Kamb
Conference paper

Abstract

During cell division, eukaryotic cells execute a basic set of steps referred to as the cell cycle (1). The cell cycle consists of 4 general time periods, or phases: G1, during which the cell grows and prepares for DNA synthesis; S, during which DNA replication occurs; G2, during which the cell continues to grow and prepares for mitosis; and M, during which cytokinesis occurs. The vast majority of cells in most tissue compartments are not continuously dividing, but rather in a resting state known as G0. When the appropriate stimulus is received, G0 - arrested cells enter the cell cycle.

Keywords

Leukemia Beach Astrocytoma Retinoblastoma 

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References

  1. 1.
    Jacobs T (1992) Control of the cell cycle. Dev Biol 153:1–15.PubMedCrossRefGoogle Scholar
  2. 2.
    Heichman KA, Roberts JM (1994) Rules to replicate by. Cell 79:557–562.PubMedCrossRefGoogle Scholar
  3. 3.
    Sherr CJ (1993) Mammalian G 1 cyclins. Cell 73:1059–1065.PubMedCrossRefGoogle Scholar
  4. 4.
    Kamb A (1995) Role of a cell cycle regulator in hereditary and sporadic cancer. In: Cold Spring Harbor Symposia on Quantitative Biology. New York: Cold Spring Harbor Laboratory Press, pp 39–47.Google Scholar
  5. 5.
    Fountain JW, Bale SJ, Housman DE, Dracopoli NC (1990) Genetics of melanoma. Cancer Sur 9: 645–650.Google Scholar
  6. 6.
    Dalbagni G, Presti J, Reuter V, et al. (1993) Genetic alterations in bladder cancer. Lancet 342:469–471.PubMedCrossRefGoogle Scholar
  7. 7.
    Cannon-Albright LA (1992) Assignment of a locus for familial melanoma MLM, to chromosome 9pl3–22. Science 258:1148–1152.PubMedCrossRefGoogle Scholar
  8. 8.
    Cannon-Albright LA, Meyer LJ, Goldgar DE, et al. (1995) Penetrance and expressivity of the chromosome 9p melanoma susceptibility locus (MLM). Cancer Res 54:6041–6044.Google Scholar
  9. 9.
    Knudson AG (1993) All in the (cancer) family. Nature Genet 5:103–104.PubMedCrossRefGoogle Scholar
  10. 10.
    Weaver-Feldhaus J, Gruis NA, Neuhausen S, et al. (1995) Localization of a putative tumor suppressor ¿ene by using homozygous deletions in melanomas. Proc Natl Acad Sci USA 91:7563–7567.CrossRefGoogle Scholar
  11. 11.
    Kamb A, Gruis NA, Weaver-Feldhaus J, et al. (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science 264:436–440.PubMedCrossRefGoogle Scholar
  12. 12.
    Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell- cycle control causing specific inhibition of cyclin D/CDK4. Nature 366:704–707.PubMedCrossRefGoogle Scholar
  13. 13.
    Lux SE, John KM, Bennett V (1990) Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue differentiation and cell-cycle control proteins. Nature 344:36–42.PubMedCrossRefGoogle Scholar
  14. 14.
    Liu Q, Neuhausen S, Skolnick MH, et al. (1995) CDKN2 (MTS1) tumor suppressor gene mutations in human tumor cell lines. Oncogene 10:1061–1067.PubMedGoogle Scholar
  15. 15.
    Gruis NA, Weaver-Feldhaus J, Liu Q, et al. (1995) Genetic evidence in melanoma and bladder cancers that pl6 and p53 function in separate pathways of tumor suppression. Am J Pathol 146:1199–1206.PubMedGoogle Scholar
  16. 16.
    Mori T, Aoki T, Nishihira T, et al. (1994) Frequent somatic mutation of the MTS1/CDK4I (Multiple Tumor Suppressor/Cyclin-dependent Kinase 4 Inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res 54:3396–3397.PubMedGoogle Scholar
  17. 17.
    Kamb A, Liu Q, Harshman K, et al. (1995) Rates of pl6 (MTS1) mutation in primary tumors with 9p loss (response). Science 265:416–417.CrossRefGoogle Scholar
  18. 18.
    Kamb A, Shattuck-Eidens D, Eeles R, et al. (1995) Analysis of CDKN2 (MTS1) as a candidate for the chromosome 9p melanoma susceptibility locus (MLM). Nature Genet 8:22–30.CrossRefGoogle Scholar
  19. 19.
    Van den Heuvel S, Harlow E (1993) Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262:2050–2054.PubMedCrossRefGoogle Scholar
  20. 20.
    Matsushime H, Ewan ME, Strom DK, et al. (1992) Identification and properties of an atypical catalytic subunit for mammalian D type cyclins. Cell 71:323–334.PubMedCrossRefGoogle Scholar
  21. 21.
    El-Diery WS, Tokino T, Velculescu VE, et al. (1993) WAF-1, a potential mediator of p53 tumor suppression. Cell 75:817–825.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1996

Authors and Affiliations

  • Alexander C. Kamb

There are no affiliations available

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