Diagnostic Imaging of Skeletal Muscle Exercise Physiology and Pathophysiology

  • Frank G. Shellock
  • Lesia L. Tyson
  • James L. Fleckenstein

Abstract

For many years, the study of skeletal muscle physiology and pathophysiology did not benefit significantly from radiological technology. This is because older technologies relied upon high-energy photons, such as x-rays and gamma rays, which are highly limited in their ability to detect the mesenchymal alterations that occur during exercise and sports injuries (Chapter 1). Moreover, the ionizing nature of these techniques prevented their use in healthy subjects for obvious ethical reasons.

Keywords

Fatigue Lactate Neurol Creatine Arena 

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References

  1. 1.
    Houghton PL, Turlington LM. Application of ultrasound for feeding and finishing animals: a review. J Anim Sei 1992;70:930–941.Google Scholar
  2. 2.
    Alexander RM, Vernon A. The dimensions of knee and ankle muscles and the forces they exert. J Hum Mov Stud 1975;1:115–123.Google Scholar
  3. 3.
    Ikai M, Fukunaga T. A study on training effect on strength per unit cross-sectional area of muscle by means of ultrasonic measurement. Int Z Angew Physiol Einschl Arbeitsphysiol 1970;28:173–180.Google Scholar
  4. 4.
    Young A, Hughes I, Russell P, Parker MJ, Nichols PJR. Measurement of quadriceps muscle wasting by ultrasonography. Rheumatol Rehabil 1980;19:141–148.PubMedCrossRefGoogle Scholar
  5. 5.
    Reimers CD, Muller W, Schmidt-Äschert M, Heldwein W, Pongratz DE. Sonographische erfassung von faszikulationen. Ultraschall 1988;9:237–239.CrossRefGoogle Scholar
  6. 6.
    Grubb RG, Fleming A, Sutherland GR, Fox KAA. Skeletal muscle contraction in healthy volunteers: assessment with Doppler tissue imaging. Radiology 1995;194:837–842.PubMedGoogle Scholar
  7. 7.
    Reimers CD, Lochmüller H, Goebels N, et al. Der Einfluß von Muskelarbeit auf das Myosonogramm. Ultraschall Med 1995;16:79–83.PubMedCrossRefGoogle Scholar
  8. 8.
    Sipilä S, Suominen H. Muscle ultrasonography and computed tomography in elderly trained and untrained women. Muscle Nerve 1993;16:294–300.PubMedCrossRefGoogle Scholar
  9. 9.
    Huang HK, Suarez FR. Evaluation of cross-sectional geometry and mass density distributions of humans and laboratory animals using computerized tomography. J Biomech 1983;16:821–832.PubMedCrossRefGoogle Scholar
  10. 10.
    Maughan RJ, Watson JS, Weir J. Strength and cross-sectional area of human skeletal muscle. J Physiol 1983;338:37–49.PubMedGoogle Scholar
  11. 11.
    Engstrom CM, Loeb GE, Reid JG, Forrest WJ, Avruch L. Morphometry of the human thigh muscles. A comparison between anatomical sections and computer tomographic and magnetic resonance images. J Anat 1991176139–156.PubMedGoogle Scholar
  12. 12.
    McColl RW, Fleckenstein JL, Bowers J, Theriault G, Peshock RM. Three dimensional reconstruction of skeletal muscles from MRI. Comput Med Imaging Graphics 1992; 16:363–371.CrossRefGoogle Scholar
  13. 13.
    Fukunaga T, Roy RR, Shellock FG, et al. Physiological cross-sectional area of human leg muscles based on magnetic resonance imaging. J Orthop Res 1992; 10:926–934.CrossRefGoogle Scholar
  14. 14.
    Roman WJ, Fleckenstein J, Stray-Gundersen J, Alway SE, Peshock R, Gonyea WJ. Adaptations in the elbow flexors of elderly males following resistance training. Spine 1993;18:582–586.CrossRefGoogle Scholar
  15. 15.
    Shellock FG, Fukunaga T, Day K, Edgerton V, Mink JH. Serial MRI and Cybex testing evaluations of exertional muscle injury: concentric vs. eccentric actions. Med Sei Sports Exerc 1990;22:S110.Google Scholar
  16. 16.
    Narici MV, Roi GS, Landoni L, Minetti AE, Cerretelli P. Changes in force, cross-sectional area and neural activation during strength training and detraining of the human quadriceps. Eur J Appl Physiol 1989;59:310–319.CrossRefGoogle Scholar
  17. 17.
    Kariya Y, Itoh M, Nakamura T, Yagi K, Kurosawa H. Magnetic resonance imaging and spectroscopy of thigh muscles in cruciate ligament insufficiency. Acta Orthop Scand 1989;60:322–325.PubMedCrossRefGoogle Scholar
  18. 18.
    LeBlanc A, Gogia P, Schneider V, Krebs J, Schonfeld E, Evans H. Calf muscle area and strength changes after five weeks of horizontal bed rest. Am J Sports Med 1988;16:624–629.PubMedCrossRefGoogle Scholar
  19. 19.
    LeBlanc A, Evans H, Schonfeld E, et al. Changes in nuclear magnetic resonance (T2) relaxation of limb tissue with bed rest. Magn Reson Med 1987;4:487–492.PubMedCrossRefGoogle Scholar
  20. 20.
    Fleckenstein JL, Haller RG, Lewis SF, Parkey RW, Peshock RM. Absence of exercise-induced MRI enhancement of skeletal muscle in McArdle’s disease. J Appl Physiol 1991;71:961–969.PubMedGoogle Scholar
  21. 21.
    Adams GR, Harris RT, Woodard D, Dudley GA. Mapping of electrical muscle stimulation using MRI. J Appl Physiol 1993;74:532–537.PubMedGoogle Scholar
  22. 22.
    Beneke R, Neuerbug J, Bohndorf K. Muscle cross-section measurement by magnetic resonance imaging. Eur J Physiol 1991;63:424–429.CrossRefGoogle Scholar
  23. 23.
    Narici MV, Roi GS, Landoni L. Force of knee extensor and flexor muscles and cross-sectional area determined by nuclear magnetic resonance imaging. Eur J Appl Physiol 1988;57:39–44.CrossRefGoogle Scholar
  24. 24.
    Narici MV, Landoni L, Minnetti AE. Assessment of human knee extensor muscle stress from in vivo physiological cross-sectional area and strength measurements. Eur J Appl Physiol 1992;65:438–444.CrossRefGoogle Scholar
  25. 25.
    LeBlanc AD, Schneider VS, Evans H, Pientok C, Rowe R, Spector E. Regional changes in muscle mass following 17 weeks of bed rest. J Appl Physiol 1992;73: 2172–2178.PubMedGoogle Scholar
  26. 26.
    Hather BM, Adams GR, Tesch PA, Dudley GA. Skeletal muscle responses to lower limb suspension in humans. J Appl Physiol 1992;72:1493–1498.PubMedGoogle Scholar
  27. 27.
    Martin PE, Mungiole M, Marzke MW, Longhill JM. The use of magnetic resonance imaging for measuring segment inertial properties. J Biomech 1989;22(4):367–376.PubMedCrossRefGoogle Scholar
  28. 28.
    Joy M, Scott G, Henkelman M. In vivo detection of applied electric currents by magnetic resonance imaging. Magn Reson Imaging 1989;7:89–94.PubMedCrossRefGoogle Scholar
  29. 29.
    English AE, Joy MLG, Henkelman RM. Pulsed NMR relaxometry of striated muscle fibers. Magn Reson Med 1991;21:264–281.PubMedCrossRefGoogle Scholar
  30. 30.
    Drace JE, Pelc NJ. Measurement of skeletal muscle motion in vivo with phase-contrast MR imaging. J Magn Reson Imaging 1994;4:157–163.PubMedCrossRefGoogle Scholar
  31. 31.
    Drace JE, Pelc NJ. Tracking the motion of skeletal muscle with velocity-encoded MR imaging. J Magn Reson Imaging 1994;4:773–778.PubMedCrossRefGoogle Scholar
  32. 32.
    Niitsu M, Campeau NG, Holsinger-Bampton AE, Riederer SJ, Ehman RL. Tracking motion with tagged rapid gradient-echo magnetization-prepared MR imaging. J Magn Reson Imaging 1992;2:155–163.PubMedCrossRefGoogle Scholar
  33. 33.
    Adzamli IK, Jolesz FA, Bleier AR, et al. The effect of gadolinium DTPA on tissue water compartments in slow-and fast-twitch rabbit muscles. Magn Reson Med 1989;11:172–181.PubMedCrossRefGoogle Scholar
  34. 34.
    Kuno S, Katsuta S, Inouye T, Anno I, Matsumoto K, Akisada M. Relationship between MR relaxation time and muscle fiber composition. Radiology 1988;169:567–568.PubMedGoogle Scholar
  35. 35.
    Kuno S, Katsuta S, Akisada M, Anno I, Matsumoto K. Effect of strength training on the relationship between relaxation time and muscle fiber composition. J Appl Physiol Occup Physiol 1990;61:33–36.CrossRefGoogle Scholar
  36. 36.
    Archer B, Fleckenstein JL, Bertocci LA, Haller RG, Barker B, Parkey RW, Peshock RM. Effect of perfusion on exercised muscle: MRI evaluation. J Magn Reson Imaging 1992;2:407–413.PubMedCrossRefGoogle Scholar
  37. 37.
    Bratton CB, Hopkins AL, Weinberg JW. Nuclear magnetic resonance studies of living muscle. Science 1965; 147: 147–148.CrossRefGoogle Scholar
  38. 38.
    Fleckenstein JL, Haller RG, Bertocci LA, Parkey RW, Peshock RM. Glycogenolysis, not perfusion, is the critical mediator of exercise-induced muscle modifications on MR images. Radiology 1992;183:25–27.PubMedGoogle Scholar
  39. 39.
    Fleckenstein JL, Canby RC, Parkey RW, Peshock RM. Acute effects of exercise on MRI of skeletal muscle in normal volunteers. AJR 1988;151:231–237.PubMedGoogle Scholar
  40. 40.
    Zhu XP, Zhao S, Isherwood I. Magnetization transfer contrast (MTC) imaging of skeletal muscle at 0.26 T— changes in signal intensity following exercise. Br J Radiol 1992;65:39–43.PubMedCrossRefGoogle Scholar
  41. 41.
    Yoshioka H, Takahashi H, Onaya H, Anno I, Niitsu M, Itai Y. Acute changes of exercised muscle using magnetization transfer contrast MR imaging. Magn Reson Imaging 1994;12:991–997.PubMedCrossRefGoogle Scholar
  42. 42.
    Mattila KT, Komu ME, Koskinen SK, Niemi PT. Exercise-induced changes in magnetization transfer contrast of muscles. Acta Radiol 1993;34:559–562.PubMedCrossRefGoogle Scholar
  43. 43.
    Weidman ER, Charles HC, Negro-Vilar R, Sullivan MG, MacFall JR. Muscle activity localization with 31P spectroscopy and calculated T2-weighted 1H images. Invest Radiol 1991;26:309–316.PubMedCrossRefGoogle Scholar
  44. 44.
    Cheng HA, Robergs RA, Letellier JP, Caprihan A, Icenogle MV, Haseler LJ. Changes in muscle proton relaxation and acidosis during incremental exercise and recovery. J Appl Physiol. In press.Google Scholar
  45. 45.
    Le Rumeur E, Carre F, Bernard AM, Bansard JY, Rochcongar P, De Certaines J. Multiparametric classification of muscle Tl and T2 relaxation times determined by magnetic resonance imaging. The effects of dynamic exercise in trained and untrained subjects. Br J Radiol 1994;67:150–156.PubMedCrossRefGoogle Scholar
  46. 46.
    Fisher MJ, Meyer RA, Adams GR, Foley JM, Potchen EJ. Direct relationship between proton T2 and exercise intensity in skeletal muscle MR images. Invest Radiol 1990;25: 480–485.PubMedCrossRefGoogle Scholar
  47. 47.
    de Kendler E, Leroy-Willig A, Jehenson P, Duboc D, Eymard B, Syrota A. Exercise-induced muscle modifications: study of healthy subjects and patients with metabolic myopathies with MR imaging and P-31 spectroscopy. Radiology 1991;181:259–264.Google Scholar
  48. 48.
    Adams GR, Duvoisin MR, Dudley GA. Magnetic resonance imaging in electromyography as indexes of muscle function. J Appl Physiol 1992;73:1578–1583.PubMedGoogle Scholar
  49. 49.
    Adams GR, Harris RT, Woodard D, Dudley GA. Mapping of electrical muscle stimulation using MRI. J Appl Physiol 1993;74:532–537.PubMedGoogle Scholar
  50. 50.
    Fleckenstein JL, Bertocci LA, Nunnally RL, Parkey RW, Peshock RM. Variation in forearm structure and function: importance in MR spectroscopy. AJR 1989; 153: 693–698.PubMedGoogle Scholar
  51. 51.
    Fleckenstein JL, Watumull D, Bertocci LA, Parkey RW, Peshock RM. Finger-specific flexor recruitment in humans: depiction by exercise-enhanced MRI. J Appl Physiol 1992; 72:1974–1977.PubMedGoogle Scholar
  52. 52.
    Fleckenstein JL, Watumull D, Mclntire DD, Bertocci LA, Chason DP, Peshock RM. Muscle proton T2 relaxation times and work during repetitive maximal voluntary exercise. J Appl Physiol 1993;74:2855–2859.PubMedGoogle Scholar
  53. 53.
    Fleckenstein JL, Adams GR. Muscle water shifts, volume changes and proton T2 relaxation times after exercise [letter]. J Appl Physiol 1993;74:2047–2048.PubMedGoogle Scholar
  54. 54.
    Fleckenstein JL, Watumull D, Bertocci LA, et al. Muscle recruitment variations during wrist flexion exercise: MRI evaluation. J Comput Assist Tomogr 1994;18:449–453.PubMedCrossRefGoogle Scholar
  55. 55.
    Flicker PL, Fleckenstein JL, Bond K, et al. Lumbar muscle usage in chronic low back pain: MRI evaluation. Spine 1993;18:582–586.PubMedCrossRefGoogle Scholar
  56. 56.
    Jenner G, Foley JM, Cooper TG, Potchen EJ. Changes in magnetic resonance images of muscle depend on exercise intensity and duration, not work. J Appl Physiol 1994;76: 2119–2124.PubMedGoogle Scholar
  57. 57.
    Jeneson JAL, Taylor JS, Vigneron DB, et al. 1H MR imaging of anatomical compartments within the finger flexor muscles of the human forearm. Magn Reson Med 1990;15:491–496.PubMedCrossRefGoogle Scholar
  58. 58.
    Jehenson P, Leroy-Willig A, de Kerviler E, Duboc D, Syrota A. MR imaging as a potential diagnostic test for metabolic myopathies: importance of variations in the T2 of muscle with exercise. AJR 1993; 161:347–351.PubMedGoogle Scholar
  59. 59.
    Le Rumeur E, De Certaines J, Toulouse P, Rochcongar P. Water phases in rat striated muscles as determined by T2 proton NMR relaxation times. Magn Reson Imaging 1987; 5:267–272.PubMedCrossRefGoogle Scholar
  60. 60.
    Morvan D, Vilgrain V, Arrive L, Nahum H. Correlation of MR changes with Doppler US measurements of blood flow in exercising normal muscle. J Magn Reson Imaging 1992; 2:645–652.PubMedCrossRefGoogle Scholar
  61. 61.
    Ploutz LL, Tesch PA, Biro RL, Dudley GA. Effect of resistance training on muscle use during exercise. J Appl Physiol 1994;76:1675–1681.PubMedGoogle Scholar
  62. 62.
    Shellock FG, Fukunaga TF, Mink JH, Edgerton VR. Acute effects of exercise on MR imaging of skeletal muscle: concentric vs eccentric actions. AJR 1991; 156: 765–768.PubMedGoogle Scholar
  63. 63.
    Yue G, Alexander AL, Laidlaw DH, Gimitro AF, Unger EC, Enoka RM. Sensitivity of muscle spin-spin relaxation time as an index of muscle activation. J Appl Physiol 1994;77:84–92.PubMedGoogle Scholar
  64. 64.
    Morvan D, Cohen-Solal A, Laperche T, Arrive L. Relationship between anaerobic metabolism involvement and proton T2 in skeletal muscle of patients with heart failure. Proc Soc Magn Reson 1994;1:251.Google Scholar
  65. 65.
    Fleckenstein JL, Weatherall PT, Bertocci LA, et al. Locomotor system assessment by muscle magnetic resonance imaging. Magn Reson Q 1991;7:79–103.PubMedGoogle Scholar
  66. 66.
    LeBlanc A, Evans H, Schonfeld E, et al. Relaxation times of normal and atrophied muscle. Med Phys 1986;13:14–517.CrossRefGoogle Scholar
  67. 67.
    Murphy WA, Totty WG, Carroll JE. MRI of normal and pathologic skeletal muscle. AJR 1986;146:565–574.PubMedGoogle Scholar
  68. 68.
    Kravis MM, Munk PL, McCain GA, Vellet Ad, Levin MF. MR imaging of muscle and tender points in fibromyalgia. J Magn Reson Imaging 1993;3:669–670.PubMedCrossRefGoogle Scholar
  69. 69.
    Polak JF, Jolesz FA, Adams DF. NMR of skeletal muscle differences in relaxation parameters related to extracellular/ intracellular fluid spaces. Invest Radiol 1988;23:107–112.PubMedCrossRefGoogle Scholar
  70. 70.
    Scholz TD, Fleagle SR, Burns TL, Skorton DJ. Tissue determinants of nuclear magnetic resonance relaxation times. Effect of water and collagen content in muscle and tendon. Invest Radiol 1989;24:893–898.PubMedCrossRefGoogle Scholar
  71. 71.
    Fleckenstein JL, Peshock RM, Lewis SF, Haller RG. Magnetic resonance imaging of muscle injury and atrophy in glycolytic myopathies. Muscle Nerve 1989; 12:849–855.PubMedCrossRefGoogle Scholar
  72. 72.
    Fleckenstein JL, Archer BT, Barker BA, Vaughan JT, Parkey RW, Peshock RM. Fast, short-tau inversion-recovery MR imaging. Radiology 1991;179:499–504.PubMedGoogle Scholar
  73. 73.
    Nurenberg P, Giddings C, Stray-Gundersen J, Fleckenstein JL, Gonyea WJ, Peshock RM. MR imaging-guided muscle biopsy for correlation of increased signal intensity with ultrastructural change and delayed-onset muscle soreness after exercise. Radiology 1992;184:865–869.PubMedGoogle Scholar
  74. 74.
    Fleckenstein JL, Weatherall PT, Parkey RW, Payne JA, Peshock RM. Sports-related muscle injuries: evaluation with MR imaging. Radiology 1989;172:793–798.PubMedGoogle Scholar
  75. 75.
    Shellock FG, Fukunaga T, Mink JH, Edgerton VR. Exertional muscle injury: evaluation of concentric versus eccentric actions with serial MR imaging. Radiology 1991; 179: 659–664.PubMedGoogle Scholar
  76. 76.
    Mehta RC, Marks MP, Hinks RS, Glover GH, Enzmann DR. MR evaluation of vertebral metastases: Tl-weighted, short inversion time inversion recovery, fast spin echo and inversion recovery fast spin echo sequences. AJNR 1995; 16:281–288.PubMedGoogle Scholar
  77. 77.
    Houmard JA, Smith R, Jendrasiak GL. Relationship between MRI relaxation times and muscle fibers. J Appl Physiol 1995;78:807–809.PubMedGoogle Scholar
  78. 78.
    Lundvall J, Mellander S, Westling H, White T. Fluid transfer between blood and tissues during exercise. Acta Physiol Scand 1972;85:258–269.PubMedCrossRefGoogle Scholar
  79. 79.
    Sjøgaard G, Saltin B. Extra- and intracellular water spaces in muscles of man at rest and with dynamic exercise. Am J Physiol 1982;12:R271–R280.Google Scholar
  80. 80.
    Sjøgaard G, Adams RP, Saltin B. Water and ion shifts in skeletal muscle of humans with intense dynamic knee extension. Am J Physiol 1985;17:R110–R196.Google Scholar
  81. 81.
    Armstrong RB. Mechanisms of exercise-induced delayed onset muscular soreness: a brief review. Med Sei Sports Exerc 1984;16:529–538.Google Scholar
  82. 82.
    Abraham WM. Factors in delayed muscle soreness. Med Sei Sports 1977;9:11–20.Google Scholar
  83. 83.
    McCully KK, Faulkner JA. Characteristics of lengthening contractions associated with injury to skeletal muscle fibers. J Appl Physiol 1986;61:293–299.PubMedGoogle Scholar
  84. 84.
    Clarkson PM, Tremblay I. Exercise-induced muscle damage, repair, and adaptation in humans. J Appl Physiol 1988;65:1–6.PubMedGoogle Scholar
  85. 85.
    Amendola A, Rorabeck CH, Vellett D, Vezina W, Rutt B, Nott L. The use of magnetic resonance imaging in exertional compartment syndromes. Am J Sports Med 1990;18:29–34.PubMedCrossRefGoogle Scholar
  86. 86.
    Evans WJ, Cannon JG. The metabolic effects of exercise-induced muscle damage. In: Holloszy JO, editor. Exercise and sport sciences reviews. Baltimore: Williams & Wilkins, 1991:99–125.Google Scholar
  87. 87.
    Friden J, Sfakianos PN, Har gens AR. Muscle soreness and intramuscular fluid pressure: comparison between eccentric and concentric load. J Appl Physiol 1986;61:2175–2179.Google Scholar
  88. 88.
    Jones DA, Newham DJ, Round JM, Tolfree SEJ. Experimental human muscle damage: morphological changes in relation to other indices of damage. J Physiol 1986;375: 435–448.PubMedGoogle Scholar
  89. 89.
    Newham DJ, McPhail G, Mills KR, Edwards RHT. Ultrastructural changes after concentric and eccentric contractions of human muscle. J Neurol Sei 1983;61:109–122.CrossRefGoogle Scholar
  90. 90.
    Frymoyer JW, Mooney V. Occupational orthopaedics. J Bone Joint Surg 1986;68:469–474.PubMedGoogle Scholar
  91. 91.
    Ireland DCR. Repetitive strain injury. Aust Fam Physician 1986;15:415–418.PubMedGoogle Scholar
  92. 92.
    Dennett X, Fry HJ. Overuse syndrome: a muscle biopsy study. Lancet 1988;l(8591):905–908.CrossRefGoogle Scholar
  93. 93.
    Larsson SE, Bengtsson A, Bodegard L, Henricksson KG, Larsson J. Muscle changes in work-related chronic myalgia. Acta Orthop Scand 1988;59:552–556.PubMedCrossRefGoogle Scholar
  94. 94.
    Lockwood AH. Medical problems of musicians. N Engl J Med 1989;320:221–227.PubMedCrossRefGoogle Scholar
  95. 95.
    Stern PJ. Tendinitis, overuse syndromes, and tendon injuries. Hand Clin 1990;6:467–476.PubMedGoogle Scholar
  96. 96.
    Simons D. Muscle pain syndromes, part 1. Am J Phys Med 1975;54:289–311.PubMedGoogle Scholar
  97. 97.
    Simons D. Muscle pain syndromes, part 2. Am J Phys Med 1976;55:15–42.PubMedGoogle Scholar

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© Springer-Verlag New York, Inc. 1996

Authors and Affiliations

  • Frank G. Shellock
  • Lesia L. Tyson
  • James L. Fleckenstein

There are no affiliations available

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