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Granulosa Cell Competence with Aging

  • Chapter
Perimenopause

Part of the book series: Serono Symposia USA ((SERONOSYMP))

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Abstract

Granulosa cells provide essential metabolic support and participate in intrafollicular communication with their accompanying oocyte. The life cycle of a granulosa cell is composed of periods of proliferation and differentiation followed by quiescence, senescence, or apoptosis. Steroids, glycoproteins, and yet to be discovered proteins are produced by these cells. This chapter examines how changes in these processes may reflect age-related changes in human granulosa cell competence that are accompanied by a decline in female fecundity.

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Authors
  1. David B. Seifer
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Editors and Affiliations

  1. Department of Obstetrics and Gynecology College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA

    Rogerio A. Lobo M.D.

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© 1997 Springer-Verlag New York, Inc.

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Seifer, D.B. (1997). Granulosa Cell Competence with Aging. In: Lobo, R.A. (eds) Perimenopause. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2288-0_11

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  • DOI: https://doi.org/10.1007/978-1-4612-2288-0_11

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7488-9

  • Online ISBN: 978-1-4612-2288-0

  • eBook Packages: Springer Book Archive

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