Interactions Between Calcium Intake and Antiresorptive Therapy in Osteoporosis
An adequate calcium intake has been shown to be beneficial to bone mass at all stages of life, however most societies have calcium intakes well below the recommended levels. Increased calcium intake maximizes peak bone mass and reduces bone loss in premenopausal women (1–4). Furthermore, calcium supplementation reduces the rate of bone loss in postmenopausal women by approximately 0.8% per year when compared with untreated women with the effect of calcium less evident in the years immediately following menopause (5, 6). As calcium effects are generally significantly less than those of standard antiresorptive therapy, calcium cannot replace antiresorptive therapy (7, 8). However, what is unknown is whether additional calcium can provide a benefit to bone mineral density (BMD) when superimposed on standard antiresorptive therapy.
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