Salt Effects on Bone and Calcium Metabolism
Salt has played a major role in the development of civilizations, and today it is a major and often hidden nutrient in the diets of many ethnic groups. Does it matter? In relation to bone and calcium metabolism the answer is probably yes, but more work is required before we can be definitive about it. Recent data from our unit raises the possibility that excessive salt directly reduces bone mass in postmenopausal women (1). In the following review we first consider possible mechanisms of action of salt on the kidney and bone. We then review what is known of the physiological effects of salt on calcium homeostasis and review the data on bone density. Finally we attempt an epidemiological perspective in terms of the importance of restricting salt intake as a public health measure to reduce osteoporotic fracture.
KeywordsCrystallization Phosphorus Magnesium Estrogen Osteoporosis
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