Abstract
It is well established that exposure of the developing or adult male to even small amounts of exogenous estrogens can cause a range of adverse changes in reproductive development or function (1, 2). Such effects have been reported in laboratory and domestic animals as well as in man (1, 3). It has been generally presumed that these effects occur primarily as a consequence of the suppression of gonadotropin secretion (4), although there are suggestions in the literature that effects of estrogens within the testis or elsewhere in the male reproductive tract are possible (1, 2, 5).
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References
Toppari J, Larsen JC, Christiansen P, Giwercman A, Grandjean P, Guillette LJ Jr, et al. Male reproductive health and environmental xenooestrogens. Environ Health Perspect 1996;104((suppl 4):741–803.
Arai Y, Mori T, Suzuki Y, Bern HA. Long-term effects of perinatal exposure to sex steroids and diethylstilbestrol on the reproductive sytem of male mammals. Int Rev Cytol 1983;84:235–68.
Sharpe RM. Could environmental oestrogenic chemicals be responsible for some disorders of human male reproductive development? Curr Opin Urol 1994;4:295–301.
Sharpe RM. Declining sperm counts in men—is there an endocrine cause? J Endocrinol 1993;136:357–60.
Li H, Papadopoulos V, Vidic B, Dym M, Culty M. Regulation of rat testis gonocyte proliferation by platelet-derived growth factor and estradiol: identification of signalling mechanisms involved. Endocrinology 1997;138:1289–98.
Turner KJ, Sharpe RM. Environmental oestrogens—present understanding. Rev Reprod 1997;2:69–73.
Sharpe RM, Skakkebaek NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 1993;341:1392–5.
Eddy EM, Washburn TF, Bunch DO, Goulding EH, Gladen BC, Lubahn DB, et al. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinology 1996;137:4796–805.
Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, et al. Estrogen resistance caused by a mutation in the estrogen receptor gene in man. N Engl J Med 1994;331:1056–61.
Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of oestrogens. J Clin Endocrinol Metab 1995;80:3689–98.
Qin K, Fisher CR, Simpson ER, Serpente S, Faustini-Fustini M, Carani C. Oligospermia and persistent linear growth of a male subject caused by a mis-sense mutation in the gene encoding aromatase. In: Program & Abstracts of 10th International Congress of Endocrinology, San Francisco, 1996 (Abstract P2–733).
White R, Jobling S, Hoare SA, Sumpter JP, Parker MG. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 1994;135:175–82.
Sharpe RM. Regulation of spermatogenesis. In: Knobil E, Neill JD, eds. The physiology of reproduction, 2nd Ed. New York: Raven Press, 1994:1363–464.
Kolho K-L, Huhtaniemi I. Suppression of pituitary-testis function in rats treated neonatally with a gonadotrophin-releasing hormone agonist and antagonist: acute and long-tenn effects. J Endocrinol 1989;123:83–91.
Kerr JB, Millar M, Maddocks S, Sharpe RM. Stage-dependent changes in spermatogenesis and Sertoli cells in relation to the onset of spermatogenic failure following withdrawal and restoration of testosterone. Anat Rec 1994;235:547–59.
Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson J-A. Cloning of a novel oestrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 1996;93:5925–30.
Kuiper GGJM, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and ß. Endocrinology 1997;138:863–70.
Fisher JS, Millar MR, Majdic G, Saunders PTK, Fraser HM, Sharpe RM. Immunolocalisation of oestrogen receptor-α (ERα) within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood. J Endocrinol 1997;153:485–95.
Abney TO, Myers RB. 17ß-Oestradiol inhibition of Leydig cell regeneration in the ethane dimethylsulfonate-treated mature rat. J Androl 1991;12:295–304.
Cigorraga SB, Sorrell S, Bator J, Catt KJ, Dufau ML. Oestrogen-dependence of a gonadotropin-induced steroidogenic lesion in rat testicular Leydig cells. J Clin Invest 1980;65:699–705.
Ilio KY, Hess RA. Structure and function of the ductuli efferentes. Microsc Res Tech 1994;29:432–67.
Nitta H, Bunick D, Hess RA, Janulis L, Newton SC, Millette CF, et al. Germ cells of the mouse testis express P450 aromatase. Endocrinology 1993;132:1396–401.
Janulis L, Hess RA, Bunick D, Nitta H, Janssen S, Osawa Y, et al. Mouse epidiymal sperm contain active P450 aromatase which decreases as sperm traverse the epididymis. J Androl 1996;17:111–6.
Meisel RL, Sachs BD. The physiology of male sexual behavior. In: Knobil E, Neill JD, eds. The physiology of reproduction, 2nd Ed., Vol. 2. New York: Raven Press, 1994:3–106.
Panno ML, Sisci D, Salerno M, Lanzino M, Mauro L, Morrone EG, et al. Effect of triiodothyronine administration on estrogen receptor contents in peripubertal Sertoli cells. Eur J Endocrinol 1996;134:633–8.
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Sharpe, R.M. et al. (1998). Estrogen Effects on Development and Function of the Testis. In: Zirkin, B.R. (eds) Germ Cell Development, Division, Disruption and Death. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2206-4_16
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DOI: https://doi.org/10.1007/978-1-4612-2206-4_16
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