Abstract
Many substances normally present in blood and those released during inflammation or tissue damage can, if they reach threshold concentration, stimulate endothelial cells (ECs) to increase synthesis and secretion of nitric oxide (1) and prostacyclin (2). These products induce smooth muscle cell relaxation and consequently vasodilatation (3). Another EC response evoked by these substances consists on increased transvascular permeability to small solutes and water across intercellular junctions (4, 5).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Blatter, L. A., Z, Taha, S. Mesaros, P. S. Shacklock, W. G. Wier, and T. Malinsky. Simultaneous measurement of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells. Circ. Res. 76:922–924, 1995.
Watanabe, K., G. Lam, and E. A. Jaffe. The correlation between rises in intracellular calcium and PGI2 production in cultured vascular endothelial cells. Prostaglandins, Leukotrienes and Essential Fatty Acids 46:211–214, 1992.
Jaffe, E. A. Physiological functions of normal endothelial cells. In: Vascular Medicine, edited by J. Loscalzo, M. A. Creager, and V. J. Dzau. Boston: Little Brown and Company, pp. 1–19, 1992.
He, P., X. Zhang, and F. E. Curry. Ca2+ entry through conductive pathway modulated receptor-mediated increase in microvessel permeability. Am. J. Physiol. 271:H2377–H2387, 1996.
Curry, F. E. Modulation of venular microvessel permeability by calcium influx into endothelial cells. FASEB J. 6:2456–2466, 1992.
Himmel, H. M., ARA. Whorton, and H. C. Strauss. Intracellular calcium, currents and stimulus-response coupling in endothelial cells. Hypertension 21:112–127, 1993.
Johns, A., T. V. Lategan, N. C. Lodge, U. S. Ryan, C. Van Bremen, and J. Adams. Calcium entry through receptor-operated channels in bovine pulmonary artery endothelial cells. Tissue and Cell 19(6):733–745, 1987.
Colden-Stanfield, M., W. P. Schilling, A. K. Ritchie, S. G. Eskin, L. T. Navarro, and D. L. Kunze. Bradykinin-induced increases in cytosolic calcium and ionic currents in cultured bovine aortic endothelial cells. Circ. Res. 61:632–640, 1987.
Morgan-Boyd, R., J. M. Stewart, R. J. Vavrek, and A. Hassid. Effects of bradykinin and angiotensin II on intracellular Ca2+ dynamics in endothelial cells. Am. J. Physiol. 253:C588–C598, 1987.
Ryan, U. S., P. V. Avdonin, E. Y. Posin, E. G. Popov, S. M. Danilov, and V. A. Tkachuk. Influence of vasoactive agents on cytoplasmic free calcium in vascular endothelial cells. J. Appl. Physiol. 65:2221–2227, 1988.
Adams, A. D., R. Lackey, and C. Van Bremen. Ion channels and regulation of intracellular calcium in vascular endothelial cells. FASEB J. 3:2390–2400, 1989.
Vargas, F. F., S. Calvo, R. Vinet, E. Garde, and E. Rojas. Cytosolic calcium rise evoked by voltage-gated calcium channels activation in adrenal medulla endothelial cells. Biol. Res. (in press).
Bean, B. P. Classes of calcium channels in vertebrate cells. Ann. Rev. Physiol. 51:367–384, 1989.
Hess, P. Calcium channels in vertebrate cells. Annu. Rev. Neurosci. 13:337–356, 1990.
Tsien, R. W., D. Lipscombe, D. V. Madison, K. R. Bley, A. P. Fox. Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci. 11:431–438, 1988.
Estacion, M. and L. J. Mordan. Expression of voltage-gated calcium channels correlates with PDGF-stimulated calcium influx and depends upon cell density in C3H 10T1/2 mouse fibroblasts. Cell Calcium 14:161–171, 1993.
Misler, S., D. W. Barnett, D. M. Pressel, K. D. Gillis, D. W. Scharp, and L. C. Falke. Stimulus-secretion coupling in β-cells of transplantable human islets of Langerhans. Diabetes 41:662–670, 1992.
Rojas, E., P. Carroll, C. Ricordi, A. Boschero, S. Stojilkovic, and I. Atwater. Control of cytosolic free calcium in cultured human pancreatic β-cells occurs by external calcium-dependent and independent mechanisms. Endocrinology 134:771–1781, 1994.
Stutzin, A., K. Stojilkovic, J. Catt, and E. G. Rojas. Characteristics of two types of calcium channels in rat pituitary gonadotrophs. Am. J. Physiol. 257:C865–C874, 1989.
Ceña, V., K. W. Brocklehurst, H. B. Pollard, and E. Rojas. Pertussis toxin stimulation of catecholamine release from adrenal medullary chromaffin cells: Mechanism may be direct activation of L-type and G-type calcium channels. J. Membr. Biol. 122:23–31, 1991.
Colden-Stanfield, M., W. P. Schilling, L. D. Possani, and D. L. Kunze. Bradykinin-induced potassium current in cultured bovine aortic endothelial cells. J. Membr. Biol. 116:227–230, 1990.
Sturek, M., P. Smith, and L. Stehno-Bittel. In vitro models of vascular endothelial cell calcium regulation. In: Ion Channels of Vascular Smooth Muscle Cells and Endothelial Cells, edited by N. Sperelakis and H. Kuriyama. New York-Amsterdam-London-Tokyo: Elsevier, pp. 349–365, 1993.
Takeda, K., V. Schini, and H. Stoeckel. Voltage activated potassium, but not calcium currents in cultured bovine aortic endothelial cells. Pflug. Arch. 410:385–393, 1987.
Vargas, F. F., P. Caviedes, and D. O. Grant. Electrophysiological characteristics of cultured human umbilical vein endothelial cells. Microvasc. Res. 47:153–165, 1994.
Bossu, J., L. A. Feltz, J. L. Rodeau, and F. Tanzi. Voltage dependent calcium transient currents in freshly dissociated capillary endothelial cells. FEBS Lett. 255:377–380, 1989.
Bossu, J., A. Elhamdani, and L. A. Feltz. Voltage-dependent calcium entry in confluent bovine capillary endothelial cells. FEBS Lett. 299:239–242, 1992.
Vinet, R. and F. F. Vargas. L-and T-type voltage-gated calcium channels in adrenal medulla microvascular endothelial cells. Submitted to Am. J. Physiol. 1997.
Vargas, F. F., R. Vinet, and S. Calvo. Voltage-gated Ca2+ channels in adrenal medulla endothelial cells and their loss during cell culture. FASEB. J. 8:A1061, 1994.
Delpiano, M. A. and B. M. Altura. Modulatory effect of extracellular Mg2+ ions on K+ and Ca2+ currents on capillary endothelial cells from rat brain. FEBS Lett. 394:335–339, 1996.
Delpiano, M. A. Ionic currents on endothelial cells of rat brain capillaries. In: Arterial Chemoreceptors: Cell to system, edited by R. G. O’Regan, P. Nolan, D. S. McQueen, and D. J. Paterson. New York: Plenum Press, pp. 183–186, 1994.
Vargas, F. F., M. E. O’Donnell, and F. E. Curry. Electrophysiology of Brain Microvascular Endothelial Cells. Microcirculation 4(1): 159, 1997.
Forsberg, E. J., G. Feuerstein, E. Shohami, and H. B. Pollard. Adenosine triphosphate stimulates inositol phospholipid metabolism and prostacyclin formation in adrenal medullary endothelial cells by means of P2-purinergic receptors. Proc. Natl. Acad. Sci. USA 84:5630–5634, 1987.
Gosink, E. C. and E. J. Forsberg. Effect of ATP and bradykinin on endothelial cell Ca2+ homeostasis and formation of cGMP and prostacyclin. Am. J. Physiol. 265:C1620–C1629, 1993.
Bossu, J. L., A. Elhamdani, A. Feltz, F. Tanzi, D. Aunis, and D. Thierse. Voltage-gated Ca entry in isolated bovine capillary endothelial cells: evidence of a new type of BAY K 8644-sensitive channel. Pflugers Arch. 420:200–207, 1992.
Laskey, R. E., D. J. Adams, A. Johns, G. M. Rubanyi, and C. van Breemen. Membrane potential and Na+-K+ pump activity modulate resting and bradykinin-stimulated changes in cytosolic free calcium in cultured endothelial cells from bovine atria. J. Biol. Chem. 265(5):2613–2619, 1990.
Luckhoff, A., and R. Busse. Alcium influx into endothelial cells and formation of endothelium-derived relaxing facror is controlled by the membrane potential. Pflugers Arch 416:305–311, 1990.
Furuya, S., C. Edwards, and R. Ornberg. Morphological behavior of cultured bovine adrenal medulla capillary endothelial cells. Tissue & Cell 22:615–628, 1990.
Voyta, J. C., D. P. Via, C. E. Butterfield, and B. R. Zetter. Identification and isolation of endothelial cells based on their increased uptake of acetylated-low density lipoprotein. J. Cell Biol. 99:2034–2040, 1984.
Banerjee, D. K., R. L. Ornberg, M. B. H. Youdim, and H. B. Pollard. Endothelial cells from bovine adrenal medulla develop capillary-like growth patterns in culture. Proc. Natl. Acad. Sci. USA. 82:4702–4706, 1985.
Hamill, O. P., A. Marty, B. Neher, B. Sakman, and F. Sigworth. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pfluegers Arch. 391:85–100, 1981.
Olesen, S. P., D. E. Clapham, and P. P. Davies. Haemodynamic shear stress activates a K current in vascular endothelial cells. Nature 331:168–170, 1988.
Mehrke, G., U. Pohl, and J. Daut. Effects of vasoactive agonists on the membrane potential of cultured bovine aortic and guinea-pig coronary endothelium. J. Physiol. (London) 439:277–299, 1991.
Lansman, J. B., T. J. Hallam, and T. J. Rink. Single stretch-activated ion channels in vascular endothelial cells as mechano-transducers? Nature, Lond. 325:811–813, 1987.
Takeda, K. and M. Keppler. Voltage-dependent and agonist-activated ionic currents in vascular endothelial cells. A Review. Blood Vessels 27:169–183, 1990.
Lori, P., G. Varadi, and A. Schwartz. Molecular insights into regulation of L-type Ca channel function. NIPS 6:277–281, 1991.
Bertolino, M. and R. R. Llinás. The central role of voltage-activated and receptor-operated calcium channels in neuronal cells. Annu. Rev. Pharmacol. Toxicol. 32:399–421, 1992.
Stojilkovic, S., A. Torsello, I. Toshihiko, E. Rojas, and K. J. Catt. Calcium signaling and secretory responses in agonist-stimulated pituitary gonadotrophs. J. Steroid Biochem. Molec. Biol. 41(3–8):453–457, 1992.
Spedding, M. and R. Paoletti. Classification of calcium channels and the sites of action of drugs modifying channel function. Pharmacol. Rev. 44:363–376, 1992.
Hess, P., B. Lansman, and R. W. Tsien. Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature 311:538–544, 1984.
Tang, C. M., F. Presser, and M. Morad. Amiloride selectively blocks the low threshold (T) calcium channel. Science 240:213–215, 1988.
Colden-Stanfield, M., E. B. Cramer, and E. K. Gallin. Comparison of apical and basal surfaces of confluent endothelial cells: Patch-clamp and viral studies. J. Physiol. 263:C573–C583, 1992.
Stojilkovic, S., M. Kukuljan, M. Tomic, E. Rojas, and J. Catt. Mechanism of agonistinduced [Ca2+]i oscillations in pituitary gonadotrophs. J. Biol. Chem. 268:7713–7720, 1993.
Laskey, R. L., D. J. Adams, M. Cannell, and C. van Breemen. Calcium-entry dependent oscillations of cytoplasmic calcium concentration in cultured endothelial cell monolayers. Proc. Natl. Acad. Sci. 89:1690–1694, 1992.
Neylon, C. B. and R. F. Irvine. Synchronized repetitive spikes in cytoplasmic calcium in confluent monolayers of human umbilical vein endothelial cells. FEBS Lett. 275:173–176, 1990.
Tracey, W. R. and M. J. Peach. Differential muscarinic receptor mRNA expression by freshly isolated and cultured bovine aortic endothelial cells. Circ. Res. 70:234–240, 1992.
Stolz, D. B. and B. S. Jacobson. Macro-and microvascular endothelial cells in vitro: Maintenance of biochemical heterogeneity despite loss of ultrastructural characteristics. In Vitro Cell. Dev. Biol. 27A:168–182, 1991.
Oike, M., G. Droogmans, and B. Nilius. Mechanosensitive Ca2+ transients in endothelial cells from human umbilical vein. Proc. Natl. Acad. Sci. USA. 91:2940–2944, 1944.
Ganong, W. F. Review of Medical Physiology. San Francisco, California: Lange Medical Publications, 1985, 295 pp.
Mizrachi, Y., P. I. Lelkes, R. L. Ornberg, G. Goping, and H. B. Pollard. Specific adhesion between pheochromocytoma (PC12) cells and adrenal medullary endothelial cells in co-culture. Cell Tissue Res. 256:365–372, 1989.
Lelkes, P. I. and B. R. Unsworth. Role of heterotypic interactions between endothelial cells and parenchymal cells in organ specific differentiation: A possible trigger for vasculogenesis. In: Angiogenesis in Health and Disease, edited by M. E. Mara-goudakis, P. Gullino, and P. I. Lelkes. New York: Plenum Press, pp. 27–43, 1992.
Ornberg, R. L., G. A. J. Kuijpers, and R. D. Leapman.Electron probe microanalysis of the subcellular compartments of bovine adrenal chromaffin cells. J. Biol. Chem. 263(3): 1488–1493, 1988.
Lelkes, P. I., V. G. Manolopoulos, D. Chick, and B. R. Unsworth. Endothelial cell heterogeneity and organ-specificity. In: Angiogenesis, Molecular Biology, Clinical Aspects, edited by M. E. Maragoudaku, P. Gullino, and P. I. Lelkes. New York: Plenum Press, pp. 1–15, 1994.
Cohen, R. A., J. T. Shepherd, and P. M. Vanhoutte. Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets. Science 221:237–238, 1983.
Ralevic, V. and G. Burnstock. Role of P2-purinoceptors in the cardiovascular system. Circulation 84(1): 1–14, 1991.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Vargas, F.F., Calvo, S., Vinet, R., Rojas, E. (1998). Interactions Between Bovine Adrenal Medulla Endothelial and Chromaffin Cells. In: Bassingthwaighte, J.B., Linehan, J.H., Goresky, C.A. (eds) Whole Organ Approaches to Cellular Metabolism. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2184-5_4
Download citation
DOI: https://doi.org/10.1007/978-1-4612-2184-5_4
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-7449-0
Online ISBN: 978-1-4612-2184-5
eBook Packages: Springer Book Archive