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The Transport of Small Molecules Across the Microvascular Barrier as a Measure of Permeability and Functioning Exchange Area in the Normal and Acutely Injured Lung

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Whole Organ Approaches to Cellular Metabolism

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Abstract

Most studies of capillary exchange in the lung have been aimed at the issue of fluid balance and an examination of factors that influence pulmonary edema. The physiology of capillary fluid exchange was established in quantitative form by Pappenheimer et al. (1951), who did their original work in peripheral systemic capillaries. Chinard and Enns (1954) pioneered the application of trace injections of radioisotopes for the estimation of extravascular water in the lung and may be said to have originated the use of the indicator dilution method in the lung. Crone (1963) and Renkin (1959) were the first to develop methods for the computation of permeability-surface area (PS) in capillaries from multiple tracer studies.

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  1. Thomas R. Harris
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Editors and Affiliations

  1. Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA

    James B. Bassingthwaighte

  2. Biomedical Engineering Department, Marquette University, Milwaukee, WI, 53233-1881, USA

    John H. Linehan

  3. Division of Gastroenterology Department of Medicine, McGill University School of Medicine, Montreal, Quebec, H3G, Canada

    Carl A. Goresky

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Harris, T.R. (1998). The Transport of Small Molecules Across the Microvascular Barrier as a Measure of Permeability and Functioning Exchange Area in the Normal and Acutely Injured Lung. In: Bassingthwaighte, J.B., Linehan, J.H., Goresky, C.A. (eds) Whole Organ Approaches to Cellular Metabolism. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2184-5_21

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  • DOI: https://doi.org/10.1007/978-1-4612-2184-5_21

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