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Whole Organ Approaches to Cellular Metabolism pp 469–494Cite as

Pulmonary Perfusion and the Exchange of Water and Acid in the Lungs

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Abstract

Studies of transport across the membranes that separate the pulmonary vasculature from the alveoli have been associated with theoretical and practical problems which have challenged the ingenuity of investigators for decades. It is difficult to distinguish between alveolar and airway transport in the intact lung, or to define the relative roles of different cells that line the alveoli. Monolayers of type II pneumocytes have been used to characterize solute transport in the distal lungs, but uncertainties persist regarding the identity and properties of these cells (Mason et al., 1982; Crandall et al., 1982). The morphology of isolated alveolar cells changes in culture from that of type II pneumocytes to flatter cells, which appear to be similar to type I pneumocytes. Since the former cover less than 5% of the surface of the lungs, they may not be representative of the normal barrier that separates the gaseous phase from the blood flowing through the lungs. Whether the cells that have been in culture for longer intervals have transport properties similar to those of the type I pneumocytes will remain uncertain unless the function of these cells can be compared with that of cells in the intact lung.

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  1. Richard M. Effros
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  2. Julie Biller
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  3. Elizabeth Jacobs
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  4. Gary S. Krenz
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Editors and Affiliations

  1. Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA

    James B. Bassingthwaighte

  2. Biomedical Engineering Department, Marquette University, Milwaukee, WI, 53233-1881, USA

    John H. Linehan

  3. Division of Gastroenterology Department of Medicine, McGill University School of Medicine, Montreal, Quebec, H3G, Canada

    Carl A. Goresky

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Effros, R.M., Biller, J., Jacobs, E., Krenz, G.S. (1998). Pulmonary Perfusion and the Exchange of Water and Acid in the Lungs. In: Bassingthwaighte, J.B., Linehan, J.H., Goresky, C.A. (eds) Whole Organ Approaches to Cellular Metabolism. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2184-5_20

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