Role of Capillary Endothelial Cells in Transport and Metabolism of Adenosine in the Heart: An Example of the Impact of Endothelial Cells on Measures of Metabolism
Endothelial cells, lying between the blood stream and the parenchymal cells of an organ, are a part of the set of signaling paths for the organ. Sensing blood solute concentrations or sensing intravascular shear can lead to the endothelial production of substances sensed or taken up by other cells. The interactions between endothelium and smooth muscle fall into a special class relating to the regulation of vasomotion. A component of the vasoregulatory system concerns the regulation of interstitial adenosine; understanding of adenosine in endothelial cells and myocytes has come slowly from early beginnings (Berne et al., 1983) and from studies of transport and exchange (Bassingthwaighte et al., 1985a,b; Gorman et al., 1986). In this chapter we provide a further set of ideas on relationships between endothelial cells and cardiac myocytes in vivo, using adenosine as the substrate of interest. These ideas hold for a variety of solutes, substrates, agonists, and pharmacologic agents, which one can choose to contemplate while reading about this local adenosine story.
KeywordsAdenosine Deaminase Capillary Endothelial Cell Adenosine Kinase Adenosine Concentration Adenosine Production
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