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Preoperative Evaluation of the Cardiothoracic Surgical Patient for Bleeding Risk

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Blood Conservation in Cardiac Surgery
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Abstract

Although bleeding and its attendant morbidity is surely a concern of all surgeons, cardiothoracic surgery presents a significant challenge with respect to the diagnosis and management of bleeding. The evaluation of a patient’s bleeding risk is an important aspect of the preoperative evaluation. But how much evaluation is appropriate? Where does cost-benefit fit in the equation? There are special concerns related to cardiothoracic surgery patients that are the consequence of coexisting disease and its therapy, and also of the nature of cardiothoracic surgery in this era. This chapter outlines some approaches to these issues, discusses some of the more commonly encountered problems, and offers an algorithm for the cardiothoracic service to use when addressing these questions at the bedside.

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References

  1. White GC, Marder VJ, Colman RW, Hirsh J, Salzman EW. Approach to the bleeding patient. In: Colman RW, Hirsh J, Marder VJ, Salzman EW, eds. Hemostasis and Thrombosis 3rd ed. Philadelphia: Lippincott, 1994.

    Google Scholar 

  2. Ferraris VA, Swanson E. Aspirin usage and perioperative blood loss in patients undergoing unexpected operations. Surg Gynecol Obstet 1983; 156:439.

    PubMed  CAS  Google Scholar 

  3. Harker LA, Slichter SJ. The bleeding time as a screening test for evaluation of platelet function. N Engl J Med 1972;287:155.

    Article  PubMed  CAS  Google Scholar 

  4. Torosian M, Michelson EL, Morganroth J, MacVaugh H. Aspirin and Coumadin related bleeding after coronary artery bypass graft surgery. Ann Intern Mod 1978;89:325.

    CAS  Google Scholar 

  5. Amrein PC, Ellman L, Harris WH. Aspirin induced prolongation of bleeding time and perioperative blood loss. JAMA 1981;245:1825.

    Article  PubMed  CAS  Google Scholar 

  6. Bashein G. Preoperative aspirin therapy and reoperation for bleeding after coronary artery bypass surgery. Arch Intern Med 1991;151:89.

    Article  PubMed  CAS  Google Scholar 

  7. Lind SE. The bleeding time does not predict surgical bleeding. Blood 1991;77:2547.

    Google Scholar 

  8. Rodgers RPC. A critical reappraisal of the bleeding time. Semin Thromb Hemost 1990;16:1.

    Article  PubMed  CAS  Google Scholar 

  9. Bick RL. Hemostasis defects associated with cardiac surgery, prosthetic devices and other extracorporeal circuits. Semin Thromb Hemost 1985;11:249.

    Article  PubMed  CAS  Google Scholar 

  10. Davis GC, Sobel M, Salzman EW. Elevated plasmafibrinopeptide A and thromboxane A2 levels during cardiopulmonary bypass. Circulation 1980;61:808.

    Google Scholar 

  11. Downing SW, Edmunds LH Jr. Release of vasoactive substances during cardiopulmonary bypass. Ann Thorac Surg 1992;54:1236.

    Article  PubMed  CAS  Google Scholar 

  12. Kirklin JK, Chenoweth DE, Naftel DC, et al. Effects of protamine administration after cardiopulmonary bypass on complement; blood elements in the hemodynamic stateAnn Thorac Surg 1986;41:193

    Article  PubMed  CAS  Google Scholar 

  13. Lowenstein E, Johnston WE, Lappas DG, et al. Catastrophic pulmonary vasoconstriction associated with protamine reversal of heparin. Anesthesiology 1983;59:470.

    Article  PubMed  CAS  Google Scholar 

  14. Morel DR, Sapol WM, Thomas SJ, et al. C5a and thromboxane generation associated with pulmonary vaso and bronchoconstriction during protamine reversal of heparin. Anesthesiology 1987;66:597.

    Article  PubMed  CAS  Google Scholar 

  15. Weiss ME, Nyhan D, Peng Z, et al. Association of protamine IgE and IgG antibodies with life-threatening reactions to intravenous protamine. N Engl J Med 1989;320:886.

    Article  PubMed  CAS  Google Scholar 

  16. Harker LA, Maplass TW, Branson HE, et al. Mechanisms of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selected alpha-granule release. Blood 1990;75:128.

    Google Scholar 

  17. Woodman RC, Harker LA. Bleeding complications associated with cardiopulmonary bypass. Blood 1990;76:1680.

    PubMed  CAS  Google Scholar 

  18. Hackman T, Gascoayne RD, Naiman SC, et al. A trial of desmopressin to reduce blood loss in uncomplicated cardiac surgery. N Engl J Med 1990;322:1085.

    Article  Google Scholar 

  19. Sloan EM, Slyono D, Klein HG, et al. DDAVP increases platelet membrane expression of glycoprotein lb in patients with disorders of platelet function and after cardiopulmonary bypass. Am J Hematol 1994;46:199.

    Article  Google Scholar 

  20. Temeck BK, Bachenheimer LC, Katz NM, et al. Desmopressin acetate in cardiac surgery: a double blind, randomized study. South Med J 1994;87:611.

    Article  PubMed  CAS  Google Scholar 

  21. Sheridan DP, Card RT, Pinilla JC, et al. Use of desmopressin acetate to reduce blood transfusion requirements during cardiac surgery in patients with acetyl- salicylic acid induced platelet dysfunction. Can J Surg 1994;37:33.

    PubMed  CAS  Google Scholar 

  22. Beck KH, Mohr P, Bleckmann U, et al. Desmopressin effect on actetylsalicylic acid impaired platelet function. Semin Thromb Hemost 1995;21:32.

    PubMed  Google Scholar 

  23. Beck KH, Bleckmann U, Mohr P, Kretschmer V. DDAVP’s shortening of the bleeding time seems due to plasma von Willebrand factor. Semin Thromb Hemost 1995;21:40.

    PubMed  Google Scholar 

  24. Stibbe J, Kluft C, Brommer EJP, et al. Enhanced fibrinolytic activity during cardiopulmonary bypass in open-heart surgery in man is caused by extrinsic (tissue-type) plasminogen activator. Eur J Clin Invest 1984;14:375.

    Article  PubMed  CAS  Google Scholar 

  25. Bidistrup BP, Royston D, Sapsford RN, Taylor KM. Reduction in blood loss and blood use after cardiopulmonary bypass with high-dose aprotinin (Trasy- lol). J Thorac Cardiovasc Surg 1989;97:364.

    Google Scholar 

  26. Rocha E, Hidalgo F, Llorens R, et al. Randomized study of aprotinin and DDAVP to reduce postoperative bleeding after cardiopulmonary bypass surgery. Circulation 1994;90:921.

    PubMed  CAS  Google Scholar 

  27. Liu B, Tengvorn L, Larson G, et al. Half-dose aprotinin preserves hemostatic function in patients undergoing bypass operations. Ann Thorac Surg 1995;59:1534.

    Article  PubMed  CAS  Google Scholar 

  28. Hendrice C, Schmartz D, Pradier O, et al. Effects of aprotinin on blood loss, heparin monitoring tests, and heparin doses in patients undergoing coronary bypass surgery. J Cardiothorac Vase Anesth 1995;9:245.

    Article  CAS  Google Scholar 

  29. Mannucci L, Gerometta PS, Mussoni L, et al. One month follow-up of hemostatic variables in patients undergoing aortocoronary bypass surgery. Effect of aprotinin. Thromb Haemost 1995;73:356.

    PubMed  CAS  Google Scholar 

  30. Rosengart TK, Helm RE, Kemperer J, et al. Combined aprotinin and erythropoietin use for blood conservation: results with Jehovah’s Witnesses. Ann Thorac Surg 1994;58:1397.

    Article  PubMed  CAS  Google Scholar 

  31. Rappaport SI. Preoperative hemostatic evaluation: which tests, if any? Blood 1983;61:229.

    Google Scholar 

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© 1998 Springer-Verlag New York, Inc.

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Asch, A.S. (1998). Preoperative Evaluation of the Cardiothoracic Surgical Patient for Bleeding Risk. In: Krieger, K.H., Isom, O.W. (eds) Blood Conservation in Cardiac Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2180-7_2

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  • DOI: https://doi.org/10.1007/978-1-4612-2180-7_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-94908-6

  • Online ISBN: 978-1-4612-2180-7

  • eBook Packages: Springer Book Archive

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