Regulation of Secretion in Human Basophils

  • Donald MacGlashanJr.


In the long history of research on allergic disease, it has been appreciated for some time that 1 the mast cell is involved in its genesis. Only more recently has the role of the human basophil been appreciated. The basophil has manysimilarities to the mast cell, possessing histamine-containing granules that are secreted when surface-bound IgE, bound to the same high-affinity receptor found on mast cells, is aggregated by antigens. However, while having these characteristics and sometimes serving as a surrogate to the mast cell because of these similarities, the basophil is a mobile leukocyte and its actual role in the progression of an allergic response has only recently been examined in some detail.1–4


Mast Cell Histamine Release Human Basophil FCeRI Expression Basophil Response 
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  • Donald MacGlashanJr.

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