The MAP Kinases and Their Role in Mast Cells and Basophils

  • Cheng Zhang
  • Michael A. Beaven


The available information on the relationships of mitogen-activated protein (MAP) kinases to mast cell function, and more so on the relationship to FcεRI-mediated function, is insufficient for meaningful review. However, meaningful scenarios can be discussed when comparisons are made with cells that have features in common with the mast cell and with other multimeric immune receptors that employ similar signaling systems to FcεRI. In this review, we provide an overview of the MAP kinases and then discuss their activation in lymphocytes and blood granulocytes before discussion of the mast cell. We have chosen for comparison with the mast cell, T and B lymphocytes, eosinophils and neutrophils because these cells express multimeric immune receptors and share some of the features of mast cells.


Mast Cell Nerve Growth Factor Mitogen Activate Protein Kinase Mitogen Activate Protein Tyrosine Phosphorylation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag New York, Inc. 1999

Authors and Affiliations

  • Cheng Zhang
  • Michael A. Beaven

There are no affiliations available

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