Regulation and Function of Protein Tyrosine Kinase Syk in FcεRI-Mediated Signaling

  • Reuben P. Siraganian
  • Juan Zhang
  • Teruaki Kimura


The FcεRI is an oligomeric structure that lacks any known enzymatic activity, and therefore this receptor depends on associated molecules for transducing intracellular signals. The COOH-terminal cytoplasmic domains of both the β and the γ subunits contain a motif with the amino acid sequence (D/E)x2Yx2Lx6–8Yx2(L/I) that is critical for cell activation.1–3 This immunoreceptor tyrosine-based activation motif (ITAM) is also present in the ζ, γ, ε, and δ subunits of the T-cell receptor complex and in Igα and Igβ of the B-cell receptor.4–8 Following stimulation of cells, phosphorylation of the tyrosine residues within the IT AM then creates binding sites for other proteins.


Mast Cell Tyrosine Phosphorylation Protein Tyrosine Kinase Cell Antigen Receptor Rosine Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag New York, Inc. 1999

Authors and Affiliations

  • Reuben P. Siraganian
  • Juan Zhang
  • Teruaki Kimura

There are no affiliations available

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