Regulation and Function of Protein Tyrosine Kinase Syk in FcεRI-Mediated Signaling

  • Reuben P. Siraganian
  • Juan Zhang
  • Teruaki Kimura
Chapter

Abstract

The FcεRI is an oligomeric structure that lacks any known enzymatic activity, and therefore this receptor depends on associated molecules for transducing intracellular signals. The COOH-terminal cytoplasmic domains of both the β and the γ subunits contain a motif with the amino acid sequence (D/E)x2Yx2Lx6–8Yx2(L/I) that is critical for cell activation.1–3 This immunoreceptor tyrosine-based activation motif (ITAM) is also present in the ζ, γ, ε, and δ subunits of the T-cell receptor complex and in Igα and Igβ of the B-cell receptor.4–8 Following stimulation of cells, phosphorylation of the tyrosine residues within the IT AM then creates binding sites for other proteins.

Keywords

Angiotensin Histamine Cytosol Phenylalanine Threonine 

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Copyright information

© Springer-Verlag New York, Inc. 1999

Authors and Affiliations

  • Reuben P. Siraganian
  • Juan Zhang
  • Teruaki Kimura

There are no affiliations available

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