Breast Care pp 242-251 | Cite as

Breast Radiation Therapy

  • Silvia Formenti

Abstract

It is now generally agreed that conservative surgery with radiation represents a valid alternative to mastectomy for treatment of stage I and II breast cancer. At present, seven prospective randomized trials have shown the equivalence of mastectomy versus conservative surgery and radiotherapy in terms of local recurrence, 5- and 10-year disease-free survival, and overall survival.1,2 Postoperative irradiation represents a fundamental component of conservative management and the NSABP-B6 study confirms the high incidence of breast cancer recurrence in patients undergoing wide excision without radiation, with 37% local recurrences in node-negative patients and 43% in node-positive patients. Instead, locoregional recurrence following conservative surgery and irradiation for early breast cancer ranges from 5% to 10% at 5 years and from 10% to 15% at 10 years.3 These figures are comparable to those achieved with mastectomy.

Keywords

Fatigue Toxicity Cage Pneumonia Fractionation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Veronesi U, Saccozzi R, Del Vecchio M, et al. Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med 1981;305:6–11PubMedCrossRefGoogle Scholar
  2. 2.
    Sarrazin D, Le MG, Arriagada R, et al. Ten-year results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancer. Radiother Oncol 1989;14:177–184PubMedCrossRefGoogle Scholar
  3. 3.
    Fisher B, Redmond C, Poisson R, et al. Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med 1989;320:822–828PubMedCrossRefGoogle Scholar
  4. 4.
    Holland R, Veling SH, Mravunac M, et al. Histologic multifocality of Tis, Tl-2 breast carcinomas: implications for clinical trials of breast-conserving surgery. Cancer 1985;56:979–990PubMedCrossRefGoogle Scholar
  5. 5.
    Liljegren G, Holmberg L, Adami HO, et al. Sector resection with or without radiotherapy for stage I breast cancer; five-year results of a randomized trial. J Natl Cancer Inst 1994;86:717–722PubMedCrossRefGoogle Scholar
  6. 6.
    Fisher R, Sass R, Fisher B, et al. Pathologic findings from the National Surgical Adjuvant Breast Project (protocol 6). II. Relation of local breast recurrence to multicentricity. Cancer 1986;57:1717–1724PubMedCrossRefGoogle Scholar
  7. 7.
    Harris JR, Sawicka J, Gelman R. Management of locally advanced carcinoma of the breast by primary radiation therapy. Int J Radiat Oncol Biol Phys 1983;9:345–349PubMedGoogle Scholar
  8. 8.
    Swain SM, Sorace RA, Bagley CS, et al. Neoadjuvant chemotherapy in the combined modality approach of locally advanced nonmetastatic breast cancer. Cancer Res 1987;47:3889–3894PubMedGoogle Scholar
  9. 9.
    Hortobagyi GN, Buzdar AU. Locally advanced breast cancer: a review including the M.D. Anderson experience. In: Ragaz J, Ariel IM (eds) High-Risk Breast Cancer-Therapy. Berlin, Springer, 1991, pp 382–415Google Scholar
  10. 10.
    Sheldon T, Hayes DF, Cady B, et al. Primary radiation therapy for locally advanced breast cancer. Cancer 1987;60:1219–1225PubMedCrossRefGoogle Scholar
  11. 11.
    Rubens RD, Sexton R, Tong D, et al. Combined chemotherapy and radiotherapy for locally advanced breast cancer. Eur J Cancer 1980;16:351–356PubMedGoogle Scholar
  12. 12.
    Formenti SC, Lenz J, Dunnington G, et al. Initial P53 status as potential predictor for pathological response to the combination of 5FU and radiotherapy in locally advanced breast cancer. ASCO Proc 1996;174Google Scholar
  13. 13.
    Formenti SC, Dunnington G, Lenz H, et al. Original p53 status predicts for pathological response in locally advanced breast cancer patients treated preoperatively with continuous infusion (C.I.) 5-fluorouracil (5-FU) and radiation therapy. Int J Radiat Oncol Biol Phys 1997;39:1059–1068PubMedCrossRefGoogle Scholar
  14. 14.
    Sherry MM, Greco FA, Johnson DH, et al. Metastatic breast cancer confined to the skeletal system: an indolent disease. Am J Med 1986;81:381–386PubMedCrossRefGoogle Scholar
  15. 15.
    Formenti SC, Lucas G, Puthawala AA, et al. Initial brachytherapy in the breast conservation approach to breast cancer. Am J Clin Oncol 1995;18:331–336PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1999

Authors and Affiliations

  • Silvia Formenti

There are no affiliations available

Personalised recommendations