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Vectors for Gene Transfer to Joints

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Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine

Part of the book series: Methods in Bioengineering ((MB))

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Abstract

Gene therapy represents a novel approach for treating joint and bone disorders (Evans et al. 1997; Evans, Ghivizzani, and Robbins 1998; Lattermann et al. 1998). As discussed in other chapters, gene transfer can be used for delivering therapeutic agents to synovium, cartilage, ligaments, tendons, meniscus, intervertebral disc, and bone to block disease progression or to promote repair. In addition, the recent completion of the first gene therapy trial for rheumatoid arthritis (RA) has demonstrated the feasibility of using gene transfer for the treatment of orthopaedic and rheumatologic disorders. The use of gene transfer to deliver a therapeutic agent offers certain advantages over the use of recombinant protein. In particular, the use of genes as therapeutic agents can results in persistent expression locally at the site of disease, bypassing the need for multiple injections and preventing possible side effects associated with systemic administration.

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Authors
  1. Paul D. Robbins
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  2. Steven C. Ghivizzani
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  3. Joseph C. Glorioso
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  4. Christopher H. Evans
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Editors and Affiliations

  1. Growth and Development Laboratory Department of Orthopaedic Surgery and Molecular Genetics and Biochemistry, Chilren’s Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, PA, 15213-2583, USA

    Johnny Huard

  2. Department of Orthopaedic Surgery Musculoskeletal Research Center Center for Sports Medicine, University of Pittsburgh, Pittsburgh, PA, 15213-2583, USA

    Freddie H. Fu

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© 2000 Birkhäuser Boston

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Robbins, P.D., Ghivizzani, S.C., Glorioso, J.C., Evans, C.H. (2000). Vectors for Gene Transfer to Joints. In: Huard, J., Fu, F.H. (eds) Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine. Methods in Bioengineering. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-2126-5_14

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  • DOI: https://doi.org/10.1007/978-1-4612-2126-5_14

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4612-7424-7

  • Online ISBN: 978-1-4612-2126-5

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