Estrogen Regulation of Cell Cycle Progression
Estrogens (Es) are essential for the normal development and physiological function of the female reproductive tract and secondary sex organs including the mammary gland. The development and progression of cancer in adult E target tissues is also dependent on E which has led to the effective use of E antagonists, particularly tamoxifen, in the treatment and potential prevention of breast cancer. The involvement of E in these major physiological and pathological processes is thought to be mediated via the potent mitogenic activity of Es. While these properties of Es have been long appreciated, it is only recently that the links between E action and the cell cycle machinery have begun to be dissected.
KeywordsCell Cycle Progression Phase Progression Cell Cycle Machinery Estrogen Regulation Hyperphosphorylated Form
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