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Quality of the Body Cell Mass pp 219–232Cite as

What Is Needed in Metabolic Research?

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Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

The earliest attempts to assess body composition involved measurement of the weight of organs and tissues obtained after death. Later, an assessment of the histology and gross composition of tissues (i.e., water, fat, protein, glycogen, and mineral) became possible. Many of the subsequent developments emerged from the need to obtain accurate information in vivo. These developments resulted from the combination of technological advances, and concepts that utilized the new technology. Figure 21.1 provides a theoretical framework for illustrating some of the important developments that have already occurred, and some of the likely future developments that will be of value in metabolic studies in vivo. The developments advance in two directions. The first is the assessment of structure from a molecular level (molecules/receptors), through the cellular, tissue, and whole-body levels, and finally to the epidemiological level. The second is the assessment of body composition from the perspective of dimensions: from one dimension (some techniques can only provide single estimates of whole body fat or fat-free mass, FFM), two (dual X-ray absorptiometry, DXA) and three dimensions (several scanning techniques), and, finally, four dimensions that take into account the short- or long-term changes in composition (from molecular to whole body composition) that occur over time. The framework offers interesting new crisscross possibilities that are likely to lead to advances in physiology, pathophysiology, diagnostic medicine, prediction of disease risk, and potential novel therapies.

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Authors
  1. Marinos Elia
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  2. Leigh C. Ward
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Editor information

Editors and Affiliations

  1. Nutrition Research Center, St. Luke’-Roosevelt Hospital Center, New York, NY, 10025, USA

    Richard N. Pierson Jr. M.D.

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© 2000 Springer-Verlag New York, Inc.

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Elia, M., Ward, L.C. (2000). What Is Needed in Metabolic Research?. In: Pierson, R.N. (eds) Quality of the Body Cell Mass. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2090-9_21

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  • DOI: https://doi.org/10.1007/978-1-4612-2090-9_21

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7410-0

  • Online ISBN: 978-1-4612-2090-9

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