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Advances in Blood Substitutes pp 167–188Cite as

Birkhäuser

Hemoglobin Oxygen Affinity and the Design of Red Cell Substitutes

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Abstract

A model is described for evaluating a number of properties of cell-free oxygen carriers with regard to their potential to produce autoregulatory vasoactivity in arterioles. The model is based on the Krogh cylinder, an idealized segment of vessel. It is unique because it “maps” the regulatory region of the arterioles - the precapillary segment which senses O2 supply and controls local vascular tone. Through a detailed analysis of the shape and position of oxygen equilibrium curves, the amount of O2 delivered to this sensitive region is analyzed as a function of diffusion, hemoglobin concentration, and P50. The results support the emerging general theory that cell-free oxygen carriers may overcome a diffusive limitation to O2 delivery to tissue, resulting in an over-supply of O2 to regulatory arterioles, leading to local vasoactivity. The model predicts that two potential strategies to overcome this limitation are to lower P50 and to lower the oxygen carrying capacity of the blood.

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Authors
  1. Robert M. Winslow M.D.
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  2. Kim D. Vandegriff Ph.D.
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Editor information

Editors and Affiliations

  1. School of Medicine, University of California, San Diego, CA, 92161, USA

    Robert M. Winslow M.D.  & Kim D. Vandegriff Ph.D.  & 

  2. Dept. of Bioengineering, University of California, San Diego, CA, 92161, USA

    Marcos Intaglietta Ph.D.

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© 1997 Springer Science+Business Media New York

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Winslow, R.M., Vandegriff, K.D. (1997). Hemoglobin Oxygen Affinity and the Design of Red Cell Substitutes. In: Winslow, R.M., Vandegriff, K.D., Intaglietta, M. (eds) Advances in Blood Substitutes. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1976-7_9

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  • DOI: https://doi.org/10.1007/978-1-4612-1976-7_9

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4612-7363-9

  • Online ISBN: 978-1-4612-1976-7

  • eBook Packages: Springer Book Archive

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