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Perflubron-based Emulsion: Efficacy as Temporary Oxygen Carrier

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Advances in Blood Substitutes

Abstract

The data summarized in this chapter constitutes the preclinical efficacy experience with perflubron-based emulsion. These data support the conclusion that IV perflubron-based emulsion improves tissue oxygenation in critical tissues such as heart and brain, that the increased O2 is available to support the metabolic processes which occur at the mitochondrial level in these tissues, and that this improved metabolic status does, indeed, translate into an improvement in organ function. These studies also demonstrate the efficacy of IV perflubron-based emulsion to support systemic oxygenation during hemodilution and intraoperative surgical bleeding as well as in the setting of cardiopulmonary bypass surgery. Finally, these results indicate that improvements in tissue oxygenation status as a result of treatment with perflubron-based emulsion are reflected by increases in systemic PvO2, suggesting that PvO2 can be considered as a potentially useful component of a transfusion trigger during perflubron-based emulsion treatment in the clinical setting of hemodilution and transfusion.

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Authors
  1. Stephen F. Flaim Ph.D.
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Editors and Affiliations

  1. School of Medicine, University of California, San Diego, CA, 92161, USA

    Robert M. Winslow M.D.  & Kim D. Vandegriff Ph.D.  & 

  2. Dept. of Bioengineering, University of California, San Diego, CA, 92161, USA

    Marcos Intaglietta Ph.D.

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Flaim, S.F. (1997). Perflubron-based Emulsion: Efficacy as Temporary Oxygen Carrier. In: Winslow, R.M., Vandegriff, K.D., Intaglietta, M. (eds) Advances in Blood Substitutes. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1976-7_6

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  • DOI: https://doi.org/10.1007/978-1-4612-1976-7_6

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4612-7363-9

  • Online ISBN: 978-1-4612-1976-7

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