Abstract
The year 1996 in the “blood substitute” literature continued to follow the trends set in 1994 and 1995. That is, there appears to be less emphasis on specific biochemical modifications of hemoglobin and perfluorocarbon chemistry, and more on clinical trials and related issues. There was an ever larger number of meetings and symposia on the subject, and even more appear to be slated for 1997, as products near the market and clinic.
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News, Reviews and Editorials
Ben-Hur, E., and B. Horowitz. Virus inactivation in blood [editorial]. AIDS 10: 1183–1190, 1996.
Dietz, N.M., M.J. Joyner, and M.A. Warner. Blood substitutes: fluids, drugs, or miracle solutions? Anesth. Analg. 82: 390–405, 1996.
Eaton, J.W. Hemoglobin-based blood substitutes: a dream-like trade of blood and guile? J. Lab. Clin. Med. 127: 416–417, 1996.
Fricker, J. Artificial blood--bad news for vampires? Lancet 347: 1322, 1996.
Gibbs, W.W. Artificial blood quickens. Several short-term substitutes approach final clinical trials. Sci. Amer. 275: 44–48, 1996.
Gould, S.A., and G.S. Moss. Clinical development of human polymerized hemoglobin as a blood substitute. World J. Surg. 20: 1200–1207, 1996.
Hensley, S. Baxter’s blood substitute OK’d for trauma testing. Mod. Healthcare 26: 16, 1996.
Hess, J.R. Blood Substitutes. Semin. Hematol. 33: 369–378, 1996.
Hess, J.R., and Reiss, R.F. Resuscitation and the limited utility of the present generation of blood substitutes. Trans. Med. Rev. X: 276–285, 1996.
Joyner, M.J., and R.J. Faust. Blood Substitutes: What is the target? In Blood Substitutes: New Challenges (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, eds). Boston: Birkhäuser, 1996, pp. 15–33.
Mallick, A., and A.R. Bodenham. Modified haemoglobins as oxygen-transporting blood substitutes. Br. J. Hosp. Med. 55: 443–448, 1996.
Sekiguchi, S., and K. Ikebuchi. [Present status and future of blood management in Japan]. Nippon Naika Gakkai Zasshi 85: 862–870, 1996.
Thomas, M.J. Royal College of Physicians, Edinburgh: final consensus statement. Consensus Conference on Autologous Transfusion, 4–6 October, 1995. Vox Sang. 70: 183–184, 1996.
Products
Bucci, E., A. Razynska, H. Kwansa, B. Matheson-Urbaitis, M. O’Hearne, J.A. Ulatowski, and R. C. Koehler. Production and characteristics of an infusible oxygen-carrying fluid based on hemoglobin intramolecularly cross-linked with sebacic acid. J. Lab. Clin. Med. 128: 146–153, 1996.
Greenwald, R.B., A. Pendri, A. Martinez, C. Gilbert, and P. Bradley. PEG thiazolidine-2-thione, a novel regent for facile protein modification: Conjugation of bovine hemoglobin. Bioconjug. Chem. 7: 638–641, 1996.
Ivanitski, G.R., and S.I. Vorob’ev. [Organization of mobile structures in the blood stream--basis for the function of perfluorocarbon “artificial blood”]. Biofizika 41: 178–190, 1996.
Leslie, S.B., S. Puvvada, B.R. Ratna, and A.S. Rudolph. Encapsulation of hemoglobin in a bicontinuous cubic phase lipid. Biochemica Biophysica Acta 1285: 246–254, 1996.
Manning, J.M. Examples of chemical modification and recombinant DNA approaches with hemoglobin. Transfus. Clin. Biol. 3: 109–111, 1996.
Pavlik, P.A., M.K. Boyd, and K.W. Olsen. Molecular dynamics of a hemoglobin crosslinking reaction. Biopolymers 39: 615–618, 1996.
Rohlfs, R.J., and K.D. Vandegriff. Non-phospholipid liposomes: A novel method for the preparation of hemoglobin-containing lipid vesicles. In Blood Substitutes: New Challenges (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, eds.). Boston: Birkhäuser, 1996, pp. 163–184.
Rollwagen, F.M., W.C. Gafney, N.D. Pacheco, T.A. Davis, T.M. Hickey, T.B. Nielsen, and A.S. Rudolph. Multiple responses to administration of liposome-encapsulated hemoglobin (LEH): Effects on hematopoiesis and serum IL-6 levels. Exp. Hematol. 24: 429–436, 1996.
Sakai, H., K. Hamada, S. Takeoka, H. Nishide, and E. Tsuchida. Physical properties of hemoglobin vesicles as red cell substitutes. Biotechnol. Prog. 12: 119–125, 1996.
Sanders, K.E., G. Ackers, and S. Sligar. Engineering and design of blood substitutes. Curr. Opinion Struct. Biol. 6: 534–540, 1996.
Szebeni, J., N.M. Wassef, A.S. Rudolph, and C.R. Alving. Complement activation in human serum by liposome-encapsulated hemoglobin: the role of natural anti-phospholipid antibodies. Biochem. Biophys. Acta 1285: 127–130, 1996.
Winslow, R.M. Blood substitutes: science or business? J. Lab. Clin. Med. 128: 126–127, 1996.
Winslow, R.M. Blood substitutes in development. Exp. Opin. Invest. Drugs 5: 1443–1452, 1996.
Hemodynamic effects
Amend, J., C. Ou, C. Ryan-MacFarlane, P.J. Anderson, N. Amend, and G.P. Biro. Systemic responses to SFHS-infusion in hemorrhaged dogs. Artif. Cells Blood Substit. Immobil. Biotechnol. 24: 19–34, 1996.
Gulati, A., A.C. Sharma, and G. Singh. Role of endothelin in the cardiovascular effects of diaspirin crosslinked and stroma reduced hemoglobin. Crit. Care Med. 24: 137–147, 1996.
Jia, L., J. Bonaventura, and J.S. Stamler. Snitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature 380: 221–226, 1996.
Kasper, S.M., M. Walter, F. Grune, A. Bischoff, H. Erasmi, and W. Buzello. Effects of a hemoglobin-based oxygen carrier (HBOC201) on hemodynamics and oxygen transport in patients undergoing preoperative hemodilution for elective abdominal aortic surgery. Anesth. Analg. 83: 921–927, 1996.
Ulatowski, J.A., T. Nishikawa, B. Matheson-Urbaitis, Bucci, E., Traystman, R.J., and R.C. Koehler. Regional blood flow alterations after bovine fumaryl (3(3-crosslinked hemoglobin transfusion and nitric oxide synthase inhibition. Crit. Care Med. 24: 558–565, 1996.
Volume and oncotic effects
Burg, M.B., E.D. Kwon, and D. Kultz. Osmotic regulation of gene expression. FASEB J. 10: 1598–1606, 1996.
Chi, O.Z., X. Lu, H.M. Wei, J.A. Williams, and H.R. Weiss. Hydroxyethyl starch solution attenuates blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats. Anesth. Analg. 83: 336–341, 1996.
Cole, D.J., J.C. Drummond, P.M. Patel, J.C. Nary, and R.L. Applegate. Effect of oncotic pressure of diaspirin cross-linked hemoglobin (DCLHb) on brain injury after temporary focal cerebral ischemia in rats. Anesth. Analg. 83: 342–347, 1996.
Detsch, O., M. Heesen, J. Muhling, A. Thiel, B. BachmannMennenga, and G. Hempelmann. Isovolaemic haemodilution with hydroxyethylstarch has no effect on somatosensory evoked potentials in healthy volunteers. Acta Anaesthesiol. Scand. 40: 665–670, 1996.
Garcia-Sepulcre, M.E., F. Carnicer, M. Mauri, A. Prieto, and M. Perez-Mateo. Increased plasma endothelin in liver cirrhosis and response to plasma volume expansion [letter]. Am. J. Gastroenterol. 91: 2452–2453, 1996.
Michel, C.C. One hundred years of Starling’s hypothesis. News Physiol. Sci. 11: 229–237, 1996.
Perfusion and regional blood flow
Gennaro, M., C. Mohan, and E. Ascer. Perfluorocarbon emulsion prevents eicoasanoid release in skeletal muscle ischemia and reperfusion. Cardiovasc. Surg. 4: 399–404, 1996.
Golubev, A.M., M.A. Magomedov, T.A. Leont’eva, and T.S. Guseinov. [The biomicroscopic evaluation of the blood microcirculatory bed in the mesentery of the small intestine during experimental perftoran infusion under normovolemia]. Morfologiia 109: 36–40, 1996.
Traylor, R.J., and R.G. Pearl. Crystalloid versus colloid versus colloid: all colloids are not created equal. Anesth. Analg. 83: 209–212, 1996.
Gas transport
Hughes, G.S., Jr., E.J. Antal, P.K. Locker, S.F. Francom, W.J. Adams, and E.E. Jacobs. Physiology and pharmacokinetics of a novel hemoglobin-based oxygen carrier in humans. Crit. Care Med. 24: 756–764, 1996.
Hughes, G.S., Jr., S.F. Francom, E.J. Antal, W.J. Adams, P.K. Locker, E.P. Yancey, and E.E. Jacobs. Effects of a novel hemoglobin-based oxygen carrier on percent oxygen saturation as determined with arterial blood gas analysis and pulse oximetry. Ann. Emerg. Med. 27: 164–169, 1996.
Keipert, P.E., N.S. Faithfull, D.J. Roth, J.D. Bradley, S. Batra, P. Jochelson, and K.E. Flaim. Supporting tissue oxygenation during acute surgical bleeding using a perfluorochemical-based oxygen carrier. Adv. Exp. Med. Biol. 388: 603–609, 1996.
Page, T.C., C.B. McKay, W.R. Light, and J.D. Hellums. Experimental simulation of oxygen transport in microvessels. In Blood Substitutes: New Challenges (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, eds). Boston: Birkhäuser, 1996, pp. 132–145.
Shah, N., and A. Mehra. Modeling of oxygen uptake in perfluorocarbon emulsions. Some comparisons with uptake by blood. ASAIO J. 42: 181–189, 1996.
Endothelium and microvascular effects
Boldt, J., M. Heesen, W. Padberg, K. Martin, and G. Hempel-mann. The influence of volume therapy and pentoxifylline infusion on circulating adhesion molecules in trauma patients. Anesthesia 51: 529–535, 1996.
Gudi, S.R.P., C.B. Clark, and J.A. Frangos. Fluid flow rapidly activates G proteins in human endothelial cells. Involvement of G proteins in mechanicochemical signal transduction. Circ. Res. 79: 834–839, 1996.
Intaglietta, M., P.C. Johnson, and R.M. Winslow. Microvascular and tissue oxygen distribution. Cardiovasc. Res. 32: 632–643, 1996.
Karmakar, N., and P. Dhar. Effect of steady shear stress on fluid filtration through the rabbit arterial wall in the presence of macromolecules. Clin. Exp. Pharmacol. Physiol. 23: 299–304, 1996.
Tsai, A.G., H. Kerger, and M. Intaglietta. Microvascular oxygen distribution: Effects due to free hemoglobin in plasma. In Blood Substitutes: New Challenges (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, eds.). Boston: Birkhäuser, 1996, pp. 124–131.
Efficacy
Conover, C.D., P. Malatesta, L. Lejeune, C.L. Chang, and R.G. Shorr. The effects of hemodilution with polyethylene glycol bovine hemoglobin (PEG-Hb) in a conscious porcine model. J. Invest. Med. 44: 238–246, 1996.
Drucker, W., F. Pearce, L. Glass-Heidenreich, H. Hopf, C. Powell, M.G. Ochsner, H. Frankel, D. Murray, M. Nelson, H. Champion, G. Rozycki, J. Silva, D. Malcolm, J. DeNobile, D. Har-viel, and N. Rich. Subcutaneous tissue oxygen pressure: a reliable index of peripheral perfusion in humans after injury. J. Trauma 40: S116–S122, 1996.
Frankel, H.L., H.B. Nguyen, T. Shea-Donohue, L.A. Aiton, J. Ratigan, and D.S. Malcolm. Diaspirin cross-linked hemoglobin is efficacious in gut resuscitation as measured by a GI tract optode. J. Trauma 40: 231–240; discussion, 241, 1996.
Leppaniemi, A., R. Soltero, D. Burris, E. Pikoulis, J. Ratigan, C. Waasdorp, H. Hufnagel, and D. Malcolm. Early resuscitation with low-volume PolyDCLHb is effective in the treatment of shock induced by penetrating vascular injury. J. Trauma 40: 242–248, 1996.
Winslow, R.M., A. Gonzales, and M. Gonzales. Physiologic effects of hemoglobin-based oxygen carriers compared to red blood cells in acute hemorrhage. [abstract] Blood 88: 626a, 1996.
Coagulation and liver function
Bleeker, W., J. Agterberg, E. La Hey, G. Rigter, L. Zappeij, and J. Bakker. Hemorrhagic disorders after administration of glutaraldehyde-polymerized hemoglobin. In Blood Substitutes: New Challenges (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, eds.). Boston: Birkhäuser, 1996, pp. 112–123.
Mardel, S.N., F. Saunders, L. 011erenshaw, C. Edwards, and D. Baddeley. Reduced quality of in-vitro clot formation with gelatin-based plasma substitutes [letter]. Lancet 347: 825, 1996.
Heath, M.L. Clot formation and gelatin-based plasma substitutes [letter]. Lancet 347: 1336, 1996.
Mardel, S.N., F.M. Saunders, L.D. 011erenshaw, and D.T. Buddeley. Haemodilution induces a hypercoagulable state [letter]. Br. J. Anaesth. 77: 700–701, 1996.
Liver function
Eldridge, J., R. Russell, R. Christenson, R. Sakamoto, J. Williams, M. Parr, B. Trump, P. Delaney, and C.F. Mackenzie. Liver function and morphology after resuscitation from severe hemorrhagic shock with hemoglobin solutions or autologous blood. Crit. Care Med. 24: 663–671, 1996.
Infection and endotoxin
Krishnamurti, C., and B. Alving. Biological consequences of cross-linked hemoglobin in animal models of surgery and endotoxemia. In Blood Substitutes: New Challenges (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, eds.). Boston: Birkhäuser, 1996, pp. 99–111.
Langermans, J.A., M. van Vuren-van der Hulst, and W.K. Bleeker. Safety evaluation of a polymerized hemoglobin solution in a murine infection model. J. Lab. Clin. Med. 127: 428–434, 1996.
Levin, J., R.I. Roth, W. Kaca, M. Yoshida, and D. Su. Hemoglobin-endotoxin interactions. In Blood Substitutes: New Challenges (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, eds.). Boston: Birkhäuser, 1996, pp. 185–202.
Neurologic injury
Reasoner, D.K., K.H. Ryu, B.J. Hindman, J. Cutkomp and T. Smith. Marked hemodilution increases neurologic injury after focal cerebral ischemia in rabbits. Anesth. Analg. 82: 61–67, 1996.
Clinical Applications
Winslow, R.M. Blood substitute oxygen carriers designed for clinical applications. In Blood Substitutes: New Challenges (R.M. Winslow, K.D. Vandegriff, and M. Intaglietta, eds.). Boston: Birkhäuser, 1996, pp. 60–73.
Shock, trauma and hemorrhage
Baron, B.J., and T.M. Scalea. Acute blood loss. Emerg. Med. Clin. North Amer. 14: 35–55, 1996.
Mackay, Z., Q. Shugufta, M. Din, and A.A. Guru. Hemodilution in complicated high velocity vascular injuries of limbs. J. Cardiovasc. Surg. (Torino) 37: 217–221, 1996.
Nho, K., R. Linberg, M. Johnson, C. Gilbert, and R. Shorr. PEG-hemoglobin: An efficient oxygen-delivery system in the rat exchange transfusion and hypovolemic shock models. Art. Cells, Blood Substit., and Immobil. Biotech. 22: 795–803, 1996.
Perioperative hemodilution
Blanloeil, Y., and Y. Leteurnier. [Indications and role of albumin for vascular loading during postoperative intensive care]. Ann. Fr. Anesth. Reanim. 15: 497–506, 1996.
Brutocao, D., S.L. Bratton, J.R. Thomas, P.F. Schrader, P.G. Coles, and A.M. Lynn. Comparison of hetastarch with albumin for postoperative volume expansion in children after cardiopulmonary bypass. J. Cardiothorac. Vasc. Anesth. 10: 348–351, 1996.
Carli, P. [Indications and role of albumin for vascular loading during prehospital care]. Ann. Fr. Anesth. Reanim. 15: 470–472, 1996.
Fosse, E., and H.E. Heier. [Changing the use of albumin at the Oslo hospital]. Tidsskr Nor Laegeforen 116: 54–57, 1996.
Freyburger, G., M. Dubreuil, M.R. Boisseau, and G. Janvier. Rheological properties of commonly used plasma substitutes during preoperative normovolaemic acute haemodilution. Br. J. Anaesth. 76: 519–525, 1996.
Gerard, J.L., and H. Bricard. [Indications and role of albumin for vascular loading in the operating room]. Ann. Fr. Anesth. Reanim. 15: 481–490, 1996.
Grathwohl, K.W., B.J. Bruns, C.J. LeBrun, A.K. Ohno, T.A. Dillard. Does hemodilution exist? Effects of saline infusion on hematologic parameters in euvolemic subjects. South Med. J. 89: 51–5, 1996.
Kreimeier, U., and K. Messmer. Hemodilution in clinical surgery: state of the art 1996. World J. Surg. 20: 1208–1217, 1996.
McCall, W.G. Physiological and practical considerations of fluid management. CRNA 7: 62–70, 1996.
Transfusion therapy
Frey, L., and K. Messmer. Transfusion therapy. Current Opin. Anaesthesiol. 9: 183–187, 1996.
Holland, P.V. Viral infections and the blood supply. N. Engl. J. Med. 334: 1734–1735, 1996.
Oberhauser, M., H.J. Bardenheuer, H. Bernasconi, T. Genz, and U. Kreimeier. [Isovolemic hemodilution for avoiding homologous blood transfusion effectiveness in large gynecologic interventions]. Infusionsther. Transfusionsmed. 23: 15–23, 1996.
Schreiber, G.B., M.P. Busch, S.H. Kleinman, and J.J. Korelitz. The risk of transfusion of transmitted viral infections. N. Engl. J. Med. 334: 1685–1690, 1006.
Burn
Guha, S.C., M.P. Kinsky, B. Button, D.N. Herndon, L.D. Traber, D.L. Traber, and G.C. Kramer. Burn resuscitation: crystalloid versus colloid versus hypertonic saline hyperoncotic colloid in sheep. Crit. Care Med. 24: 1849–1857, 1996.
Liquid ventilation
Leach, C.L., J.S. Greenspan, D.S. Rubenstein, T.H. Shaffer, M.R. Wolfson, J.C. Jackson, R. DeLemos, and B.P. Fuhrman. Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome. New Eng. J. Med. 335: 761–767, 1996.
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Winslow, R.M. (1997). Blood Substitutes: 1996 in the Literature. In: Winslow, R.M., Vandegriff, K.D., Intaglietta, M. (eds) Advances in Blood Substitutes. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1976-7_1
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DOI: https://doi.org/10.1007/978-1-4612-1976-7_1
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